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Chemical Compound Review

CUMARINA     chromen-2-one

Synonyms: coumarin, Coumarine, Kumarin, cumarin, Rattex, ...
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Disease relevance of coumarin


High impact information on coumarin


Chemical compound and disease context of coumarin

  • In the pesticide category, most of the information related to poisonings with pyrethroids, followed by organophosphorous compounds, coumarine derivatives, carbamates [11].

Biological context of coumarin


Anatomical context of coumarin


Associations of coumarin with other chemical compounds


Gene context of coumarin


Analytical, diagnostic and therapeutic context of coumarin

  • CASE REPORTS: The first patient, an adolescent girl, developed multiple thrombotic shunt occlusions after the initiation of hemodialysis until continuous cumarin anticoagulation was instituted [25].


  1. Treatment of lymphedema of the arms and legs with 5,6-benzo-[alpha]-pyrone. Casley-Smith, J.R., Morgan, R.G., Piller, N.B. N. Engl. J. Med. (1993) [Pubmed]
  2. Treatment of metastatic renal cell carcinoma with coumarin (1,2-benzopyrone) and cimetidine: a pilot study. Marshall, M.E., Mendelsohn, L., Butler, K., Riley, L., Cantrell, J., Wiseman, C., Taylor, R., Macdonald, J.S. J. Clin. Oncol. (1987) [Pubmed]
  3. Treatment with coumarin to prevent or delay recurrence of malignant melanoma. Thornes, R.D., Daly, L., Lynch, G., Breslin, B., Browne, H., Browne, H.Y., Corrigan, T., Daly, P., Edwards, G., Gaffney, E. J. Cancer Res. Clin. Oncol. (1994) [Pubmed]
  4. Cloricromene, a coumarine derivative, reduced the development of periodontitis in rats. Muià, C., Mazzon, E., Zito, D., Maiere, D., Britti, D., Crisafulli, C., Oteri, G., Cordasco, G., Cuzzocrea, S. Naunyn Schmiedebergs Arch. Pharmacol. (2006) [Pubmed]
  5. Reduction of filaritic lymphoedema and elephantiasis by 5,6 benzo-alpha-pyrone (coumarin), and the effects of diethylcarbamazine (DEC). Casley-Smith, J.R., Jamal, S., Casley-Smith, J. Ann. Trop. Med. Parasitol. (1993) [Pubmed]
  6. Prevention of tumorigenesis of oncogene-transformed rat fibroblasts with DNA site inhibitors of poly(ADP ribose) polymerase. Tseng, A., Lee, W.M., Jakobovits, E.B., Kirsten, E., Hakam, A., McLick, J., Buki, K., Kun, E. Proc. Natl. Acad. Sci. U.S.A. (1987) [Pubmed]
  7. Coumarin derivatives enhance the chemiluminescence accompanying lipid peroxidation. Vladimirov, Y.A., Sharov, V.S., Driomina, E.S., Reznitchenko, A.V., Gashev, S.B. Free Radic. Biol. Med. (1995) [Pubmed]
  8. Cloricromene, a coumarine derivative, protects against collagen-induced arthritis in Lewis rats. Cuzzocrea, S., Mazzon, E., Bevilaqua, C., Costantino, G., Britti, D., Mazzullo, G., De Sarro, A., Caputi, A.P. Br. J. Pharmacol. (2000) [Pubmed]
  9. Treatment of hormone-refractory stage D carcinoma of prostate with coumarin (1,2-benzopyrone) and cimetidine: a pilot study. Marshall, M.E., Butler, K., Hermansen, D. Prostate (1990) [Pubmed]
  10. The influence of cyclo-oxygenase specificity of non-steroidal anti-inflammatory drugs on bleeding complications in concomitant coumarine users. Knijff-Dutmer, E.A., Van der Palen, J., Schut, G., Van de Laar, M.A. QJM : monthly journal of the Association of Physicians. (2003) [Pubmed]
  11. Telephone toxicological information service on pesticide poisonings. Jaraczewska, W., Kotwica, M., Jarosz, A., Kołaciński, Z. Prz. Lek. (1997) [Pubmed]
  12. Comparative in vitro skin absorption and metabolism of coumarin (1,2-benzopyrone) in human, rat, and mouse. Beckley-Kartey, S.A., Hotchkiss, S.A., Capel, M. Toxicol. Appl. Pharmacol. (1997) [Pubmed]
  13. Pharmacokinetic and pharmacodynamic properties of oral anticoagulants, especially phenprocoumon. Haustein, K.O. Semin. Thromb. Hemost. (1999) [Pubmed]
  14. Amelioration of ferric nitrilotriacetate (Fe-NTA) induced renal oxidative stress and tumor promotion response by coumarin (1,2-benzopyrone) in Wistar rats. Khan, N., Sharma, S., Sultana, S. Cancer Lett. (2004) [Pubmed]
  15. Coumarin inhibits the growth of carrot (Daucus carota L. cv. Saint Valery) cells in suspension culture. Abenavoli, M.R., Sorgonà, A., Sidari, M., Badiani, M., Fuggi, A. J. Plant Physiol. (2003) [Pubmed]
  16. The effect of cloricromene, a coumarine derivative, on leukocyte accumulation, myocardial necrosis and TNF-alpha production in myocardial ischaemia-reperfusion injury. Squadrito, F., Altavilla, D., Zingarelli, B., Ioculano, M., Calapai, G., Campo, G.M., Miceli, A., Prosdocimi, M., Caputi, A.P. Life Sci. (1993) [Pubmed]
  17. Effects of coumarin (1,2-benzopyrone) on lymphocyte, natural killer cell, and monocyte functions in vitro. Marshall, M.E., Conley, D., Hollingsworth, P., Brown, S., Thompson, J.S. Journal of biological response modifiers. (1989) [Pubmed]
  18. Attenuation of potassium bromate-induced nephrotoxicity by coumarin (1,2-benzopyrone) in Wistar rats: chemoprevention against free radical-mediated renal oxidative stress and tumor promotion response. Khan, N., Sharma, S., Sultana, S. Redox Rep. (2004) [Pubmed]
  19. The protein-labeling reagent FLASH-EDT2 binds not only to CCXXCC motifs but also non-specifically to endogenous cysteine-rich proteins. Stroffekova, K., Proenza, C., Beam, K.G. Pflugers Arch. (2001) [Pubmed]
  20. Interstitial fluid pressure in rat skin becomes more negative in the initial phase of carrageenan-induced edema. Rodt, S.A., Reed, R.K. International journal of microcirculation, clinical and experimental / sponsored by the European Society for Microcirculation. (1993) [Pubmed]
  21. Effect of a combination of coumarin derivatives and rutoside on venous and lymphatic circulations during severe constriction of the caudal vena cava in rabbits. Borzeix, M.G., Angignard, J., Dedieu, F., Dupont, J.M., Miloradovich, T., Leutenegger, E. Arzneimittel-Forschung. (1995) [Pubmed]
  22. A novel fluorometric ultramicro determination of serum leucine aminopeptidase using a coumarine derivative. Saifuku, K., Sekine, T., Namihisa, T., Takahashi, T., Kanaoka, Y. Clin. Chim. Acta (1978) [Pubmed]
  23. Prevention of early recurrence of high risk malignant melanoma by coumarin. Irish Melanoma Group. Thornes, D., Daly, L., Lynch, G., Browne, H., Tanner, A., Keane, F., O'Loughlin, S., Corrigan, T., Daly, P., Edwards, G. European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology. (1989) [Pubmed]
  24. Disposition characteristics of coumarin as a function of age in the beagle dog model. Ritschel, W.A., Vachharajani, N.N. Arzneimittel-Forschung. (1993) [Pubmed]
  25. Heterozygous prothrombin gene mutation: a new risk factor for early renal allograft thrombosis. Oh, J., Schaefer, F., Veldmann, A., Nowak, G., Nowak-Göttl, U., Tönshoff, B., Kreuz, W. Transplantation (1999) [Pubmed]
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