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Chemical Compound Review

Phenoclor DP6     1,2,3-trichloro-4-(2,3,4...

Synonyms: Arochlor 1260, AROCLOR 1260, Clophen A 60, CCRIS 901, PCB-1260, ...
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Disease relevance of PCB 128


High impact information on PCB 128

  • Analysis of the rodent carcinogenicity data for Aroclor 1260 using the TEF approach suggests that this response is primarily Ah-receptor-independent [5].
  • Triplicate cultures of the eighth transfer without sediment dechlorinated 76% of the hexa- through nonachlorobiphenyls in Aroclor 1260 (250 mug/ml) to tri- through pentachlorobiphenyls in 110 days [6].
  • Following 4 months of anaerobic treatment with an enrichment culture, all of the major components in Aroclor 1260 were completely or partially transformed to less chlorinated PCB congeners [7].
  • The hepatic tumor promoting activity of the planar 0-1 ortho ( approximately 9.7% w/w) and the nonplanar 2-4 ortho ( approximately 90.3% w/w) fraction of the commercial PCB mixture Aroclor 1260 was studied using a medium-term two-stage initiation/promotion bioassay in female Sprague-Dawley rats [8].
  • To evaluate the effect of exposure to an environmentally relevant polychlorinated biphenyl mixture, adult male rats were treated with Aroclor 1260 for 7 days and levels of several cytochrome P450 (CYP) enzymes were measured in liver microsomes prepared 3 days after the last dose [2].

Chemical compound and disease context of PCB 128

  • The commercial polychlorinated biphenyl (PCB) formulation Aroclor 1260 (4 mg/kg body weight), technical grade dichlorodiphenyltrichloroethane (DDT; 3 mg) and Lindane (gamma-hexachlorocyclohexane; 0.8 mg) were administered orally, either separately or in combination, to sexually mature female rabbits three times per week for 12-15 weeks [9].
  • In men, relationships between changes in plasma HCB, Aroclor 1260, and PCB-153 concentrations and those in fasting insulin levels in response to weight loss remained significantly correlated after correction for fat mass loss (-.46 < partial r < -.51, P values ranging from.05 to.07) [10].

Biological context of PCB 128

  • However, the extent of apoptosis resulted greater for Aroclor 1248 than for Aroclor 1260 [11].
  • The addition of Aroclor 1260 had a significant impact on abundance, biomass, and cell size of autotrophic and heterotrophic picoplankton, and reduced significantly bacterial secondary production [12].
  • An analysis of individual PCB congener signatures in plant site background samples using principal components analysis (PCA) revealed that the past use of specific commercial PCB formulations at these sites, such as Aroclor 1260 on the east coast, is reflected in the PCB congener signature present in the plants [13].
  • We determined for PCB 128, when administered in a diet to Sprague-Dawley rats, the no observable adverse effect level (NOAEL) is < 0.5 ppm [14].
  • Effect of polychlorinated biphenyl (Aroclor 1260) on histology of kidney and thyroid of rats [15].

Anatomical context of PCB 128


Associations of PCB 128 with other chemical compounds

  • Ethoxyresorufin O-deethylase activity and CYP1A1 protein levels displayed linear dose-dependent increases, but the hepatic CYP1A1 content did not exceed 10% that of CYP2B1 at all dosages of Aroclor 1260 [2].
  • The time course studies also revealed that in the first 3 days of feeding, significant increases in CYP1A1 were found in intestine (betaNF: 320% and Aroclor-1260: 290%), followed by liver (betaNF: 144%, Aroclor-1260: 123% and Aroclor-1254: 110%) [20].
  • Residues of DDT (mainly as DDE), trans-nonachlor, dieldrin, Aroclor 1260, mirex, and petroleum hydrocarbons were common in fish from the lower Savannah River, but concentrations were below those warranting environmental concern [21].
  • Based on our previous work, PCB 128 is estimated to be equally toxic as PCB 153, another di-ortho substituted PCB congener [22].

Gene context of PCB 128


Analytical, diagnostic and therapeutic context of PCB 128


  1. Polychlorinated biphenyl induction of hepatocellular carcinoma in the Sprague-Dawley rat. Norback, D.H., Weltman, R.H. Environ. Health Perspect. (1985) [Pubmed]
  2. Induction of hepatic CYP2B is a more sensitive indicator of exposure to aroclor 1260 than CYP1A in male rats. Ngui, J.S., Bandiera, S.M. Toxicol. Appl. Pharmacol. (1999) [Pubmed]
  3. Increase in plasma pollutant levels in response to weight loss in humans is related to in vitro subcutaneous adipocyte basal lipolysis. Imbeault, P., Chevrier, J., Dewailly, E., Ayotte, P., Després, J.P., Tremblay, A., Mauriège, P. Int. J. Obes. Relat. Metab. Disord. (2001) [Pubmed]
  4. Subchronic toxicity of 2,2',3,3',4,4'-hexachlorobiphenyl in rats. Lecavalier, P., Chu, I., Yagminas, A., Villeneuve, D.C., Poon, R., Feeley, M., Håkansson, H., Ahlborg, U.G., Valli, V.E., Bergman, A., Seegal, R.F., Kennedy, S.W. Journal of toxicology and environmental health. (1997) [Pubmed]
  5. Polychlorinated biphenyls (PCBs): environmental impact, biochemical and toxic responses, and implications for risk assessment. Safe, S.H. Crit. Rev. Toxicol. (1994) [Pubmed]
  6. Development and characterization of stable sediment-free anaerobic bacterial enrichment cultures that dechlorinate aroclor 1260. Bedard, D.L., Bailey, J.J., Reiss, B.L., Jerzak, G.V. Appl. Environ. Microbiol. (2006) [Pubmed]
  7. Sequential anaerobic-aerobic treatment of soil contaminated with weathered Aroclor 1260. Master, E.R., Lai, V.W., Kuipers, B., Cullen, W.R., Mohn, W.W. Environ. Sci. Technol. (2002) [Pubmed]
  8. Contribution of planar (0-1 ortho) and nonplanar (2-4 ortho) fractions of Aroclor 1260 to the induction of altered hepatic foci in female Sprague-Dawley rats. van der Plas, S.A., Sundberg, H., van den Berg, H., Scheu, G., Wester, P., Jensen, S., Bergman, A., de Boer, J., Koeman, J.H., Brouwer, A. Toxicol. Appl. Pharmacol. (2000) [Pubmed]
  9. Effects of persistent chlorinated hydrocarbons on fertility and embryonic development in the rabbit. Seiler, P., Fischer, B., Lindenau, A., Beier, H.M. Hum. Reprod. (1994) [Pubmed]
  10. Increase in plasma pollutant levels in response to weight loss is associated with the reduction of fasting insulin levels in men but not in women. Imbeault, P., Chevrier, J., Dewailly, E., Ayotte, P., Després, J.P., Mauriège, P., Tremblay, A. Metab. Clin. Exp. (2002) [Pubmed]
  11. Polychlorinated biphenyl mixtures (Aroclors) induce apoptosis via Bcl-2, Bax and caspase-3 proteins in neuronal cell cultures. Sánchez-Alonso, J.A., López-Aparicio, P., Recio, M.N., Pérez-Albarsanz, M.A. Toxicol. Lett. (2004) [Pubmed]
  12. Impact of heavy metals and PCBs on marine picoplankton. Caroppo, C., Stabili, L., Aresta, M., Corinaldesi, C., Danovaro, R. Environ. Toxicol. (2006) [Pubmed]
  13. Vascular plants as sensitive indicators of lead and PCB transport from local sources in the Canadian Arctic. Dushenko, W.T., Grundy, S.L., Reimer, K.J. Sci. Total Environ. (1996) [Pubmed]
  14. Stereology of PCB 128-induced ultrastructural alterations in the rat liver. Walker, I., Singh, A., Chu, I. J. Submicrosc. Cytol. Pathol. (2000) [Pubmed]
  15. Effect of polychlorinated biphenyl (Aroclor 1260) on histology of kidney and thyroid of rats. Rao, C.V., Banerji, S.A. Indian J. Exp. Biol. (1990) [Pubmed]
  16. Comparison of effects of Aroclors 1016 and 1260 on non-human primate catecholamine function. Seegal, R.F., Bush, B., Brosch, K.O. Toxicology (1991) [Pubmed]
  17. Distribution and elimination in vivo of polychlorinated biphenyl (PCB) isomers and congeners in the pigeon. Borlakoglu, J.T., Wilkins, J.P., Dils, R.R. Xenobiotica (1991) [Pubmed]
  18. Organochlorine levels in maternal and umbilical cord blood plasma in Arctic Canada. Butler Walker, J., Seddon, L., McMullen, E., Houseman, J., Tofflemire, K., Corriveau, A., Weber, J.P., Mills, C., Smith, S., Van Oostdam, J. Sci. Total Environ. (2003) [Pubmed]
  19. A rapid method for determination of Aroclor 1260 in cattle adipose tissue. Kumar, Y., Humphries, D. Journal of environmental science and health. Part. B, Pesticides, food contaminants, and agricultural wastes. (1996) [Pubmed]
  20. Differential expression of CYP1A1 mRNA in gill, intestine and liver of tilapia fed with PCB Aroclor-1254 and Aroclor-1260 spiked food. Yeung, H.Y., Wong, C.C., Wong, M.H., Wong, C.K. Chemosphere (2003) [Pubmed]
  21. Environmental contaminant concentrations in biota from the lower Savannah River, Georgia and South Carolina. Winger, P.V., Schultz, D.P., Johnson, W.W. Arch. Environ. Contam. Toxicol. (1990) [Pubmed]
  22. PCB 128-induced ultrastructural lesions in the rat liver. Singh, A., Connell, B.J., Chu, I. J. Submicrosc. Cytol. Pathol. (2000) [Pubmed]
  23. Acute exposure to aroclor 1016 or 1260 differentially affects dopamine transporter and vesicular monoamine transporter 2 levels. Richardson, J.R., Miller, G.W. Toxicol. Lett. (2004) [Pubmed]
  24. Chlorinated contaminants in chorio-allantoic membranes from great blue heron eggs at Whidbey Island Naval Air Station. Cobb, G.P., Norman, D.M., Miller, M.W., Brewer, L.W., Johnston, R.K. Chemosphere (1995) [Pubmed]
  25. Radioimmunoassay of PCBs in milk and blood. Newsome, W.H., Shields, J.B. International journal of environmental analytical chemistry. (1981) [Pubmed]
  26. Determination of Mirex in human blood serum containing polychlorinated biphenyls by using packed column gas chromatography. Korver, M.P., Burse, V.W., Needham, L.L., Green, V.E., Gray, D.L., Rouse, M.A., Shelly, T.L., Mortensen, B.K. Journal - Association of Official Analytical Chemists. (1991) [Pubmed]
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