Disease relevance of Glycodeoxycholate

• Acute pancreatitis was induced by intraductal glycodeoxycholate and intravenous cerulein infusion [1].

High impact information on Glycodeoxycholate

• Increases of intracellular magnesium promote glycodeoxycholate-induced apoptosis in rat hepatocytes [2].
• The cats either received ethanol (2 ml/kg every 8 h) and aspirin (25 mg/kg every 8 h) orally for 48 h or had their pancreatic ducts perfused for 1 h with 7.5 mM glycodeoxycholate [3].
• Based upon the aqueous monomeric solubilities of cholesterol (C27) and beta-sitosterol (C29) at 24 degrees C, we derived free energy changes associated with micellar binding and found that solubilization of both sterols was more energetically favored in glycodeoxycholate solutions [4].
• Introduction of micelle-forming bile salts (taurocholate or glycodeoxycholate) to the perfusion medium 80 min after liver isolation markedly increased the output of plasma-membrane enzymes but had no effect on the other proteins [5].
• The assay has been used to study the effects of pH, Ca2+, ionic strength abd glycodeoxycholate on enterokinase activity [6].

Chemical compound and disease context of Glycodeoxycholate

• Those animals that received PGE2, glycodeoxycholate, and enterokinase all developed pancreatitis [7].

Biological context of Glycodeoxycholate

• In vivo buccal delivery of the peptide drug buserelin with glycodeoxycholate as an absorption enhancer in pigs [8].
• Binding characteristics of [3H]opioid ligands to active opioid binding sites solubilized from rat brain membranes by glycodeoxycholate and NaCl: the recovery of binding activity by dilution [9].
• Co-administration of 10 mM GDC increased the absolute bioavailability from 1.8+/-0.5 to 12.7+/-2.0% for FD4 [10].
• Reduced solute absorption in the presence of glycodeoxycholate and oleate, therefore, cannot be attributed to an effect on active transport alone [11].

Anatomical context of Glycodeoxycholate

• High affinity, stereospecific binding to soluble sites was demonstrable when membranes from rat brain, human frontal cortex and bovine corpus striatum were treated with digitonin or glycodeoxycholate, provided that the binding assay was conducted at 25 degrees C or below and in the presence of 50 to 100 mM NaCl [12].
• Rabbit duodenal and jejunal brush-border membrane vesicle integrity, fluidity and passive proton permeability were studied after in vitro exposure to deoxycholate, glycodeoxycholate or taurodeoxycholate [13].
• In vitro permeation of ddC across porcine buccal mucosa was conducted in isotonic McIlvaine buffer solution (IMB) using in-line flow through diffusion cells at 37 degrees C. Sodium glycodeoxycholate (GDC) was used as the permeation enhancer in the permeation enhancement studies [14].
• The following rank order of relative bile salt concentration in duodenum was observed: taurocholic acid > glycocholate >or= glycochenodeoxycholate > glycodeoxycholate > taurochenodeoxycholate > taurodeoxycholate [15].
• Histological changes observed in the buccal epithelium after 4 h contact with the tablets containing GDC recovered completely within 24 h after removal [16].

Associations of Glycodeoxycholate with other chemical compounds

• A randomized cross-over study including intravenous administration and buccal delivery without and with 10 mM sodium glycodeoxycholate (GDC) as an absorption enhancer was performed in pigs [10].
• In-vivo buccal delivery of fluorescein isothiocyanate-dextran 4400 with glycodeoxycholate as an absorption enhancer in pigs [17].
• As in studies with solutions of either taurocholate (TC), glycocholate (GC) or glycodeoxycholate (GDC) the results were compared to the increase in P(app) of mannitol obtained in analog studies using porcine buccal mucosa in an Ussing chamber [18].
• The enhancers studied were lysophosphatidylcholine, glycodeoxycholate and sodium taurodihydroxyfusidate, a bile salt derivative [19].
• Jejunal perfusion studies were performed in 12 healthy volunteers to study the effects of 14 and 56 mM glucose on fluid secretion induced by 5 mM glycodeoxycholate on 7 mM oleate [11].

Gene context of Glycodeoxycholate

• A mixture of ten steroids was separated by microemulsion and micellar (SDS and glycodeoxycholate) electrokinetic chromatography systems [20].

Analytical, diagnostic and therapeutic context of Glycodeoxycholate

• Activity of the activated enzyme could not be further elevated by exogenous calpain, even after treatment of the membranes with glycodeoxycholate [21].
• The transport of the bile salt, glycodeoxycholate, was studied in vesicles derived from rat jejunal and ileal brush border membranes using a rapid filtration technique [22].

References