Disease relevance of C10983

• Mice were given 2.5 and 5.0 ppm cyhalothrin/kg body weight orally [1].
• Thus, inhibitory avoidance tests carried out on rats at 90 days of age were capable of demonstrating neural toxicity of Cyhalothrin (0.02%) present only in the drinking water of dams during 21 days of lactation [2].

Psychiatry related information on C10983

• The exploratory behavior of the rats prenatally exposed to cyhalothrin decreased [3].

High impact information on C10983

• Half-maximal inhibition was observed at 0.73 microM permethrin and 0.57 microM cyhalothrin, respectively, and exhibited sigmoidal inhibition kinetics [4].
• In order to obtain a more complete understanding of pyrethroid neurotoxicity, effects of the pyrethroid insecticides, allethrin (type I), cyhalothrin (type II) and deltamethrin (type II) on extracellular levels of dopamine (DA) and its metabolites in the striatum of conscious rats were studied by in vivo microdialysis [5].
• Synthetic pyrethroids such as cyhalothrin are extensively used in agriculture for the control of a broad range of ectoparasites in farm animals [6].
• The extraction of fenpropathrin, cyhalothrin, cypermethrin, fenvalerate and deltamethrin from tobacco (Nicotina tobaccum) and cigarette smoke condensate with acetone, followed by partition of resulting acetone mixture with petroleum ether, was investigated and found suitable for capillary gas chromatography (GC) residue analysis [7].
• In vitro study showed that at higher concentrations (> or = 10(-) (6) M) allethrin and cyhalothrin reduced the hippocampal HACU but deltamethrin increased it [8].

Biological context of C10983

• Results showed that in vivo cyhalothrin treatment: (1) decreased macrophage spreading and phagocytosis indexes; (2) decreased macrophage nitric oxide (NO) production; (3) did not change spontaneous or PMA-induced macrophage H2O2 release [9].
• Field trials on cattle confirmed that dipping in 0.007% cyhalothrin provided a high level of tick control and a minimum of 7 days protective period against reinfestation [10].
• The prenatal effects of exposure to the insecticide cyhalothrin on the sexual maturation and sexual behavior of rats were investigated [11].
• Laboratory and field populations were examined by both the PCR assay and conventional filter paper bioassays with the pyrethroid cyhalothrin to verify that populations containing greater proportions of individuals with the resistant sodium channel allele DNA sequence also had higher bioassay LC50 values [12].

Anatomical context of C10983

• Effects of type II pyrethroid cyhalothrin on peritoneal macrophage activity in rats [9].

Associations of C10983 with other chemical compounds

• Insecticidal dipping fluid emulsions, mixed in vitro in dam water containing suspended clay particles and 1% w/v zinc sulphate, were analysed to determine rates of settling of diazinon, cyhalothrin and cypermethrin [13].
• In regulated treatment trials with 0.007% cyhalothrin, greater than 99% control of the Biarra, Mackay, Mt Alford, DDT resistant and Ulam cattle tick strains was obtained [10].
• Horn fly populations from Arkansas resistant to cyhalothrin (as a result of exposure to cyhalothrin ear tags) were cross-resistant to pirimiphos methyl [14].
• Results of these bioassays indicated resistance to cypermethrin, deltamethrin, cyhalothrin and alphacypermethrin [15].

Gene context of C10983

• Standard curves, estimates of recovery efficiency, and specific GC-MS SIM quantification methods were developed for common pesticides including diazinon. aldrin, chlorpyrifos, malathion, dieldrin, DDT, permethrin, cyhalothrin, and cypermethrin, and for seven selected PCBs [16].

Analytical, diagnostic and therapeutic context of C10983

• Development of an enzyme-linked immunosorbent assay for the pyrethroid insecticide cyhalothrin [17].
• Residual activity of cyhalothrin 20% EC on cattle as determined by mosquito bioassays [18].

References