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Chemical Compound Review

Aeralfam     [cyano-(3- phenoxyphenyl)methyl] (1R,3R)-3...

Synonyms: Ultimate, Alfazot, Concord, Contest, Dominex, ...
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Disease relevance of Dominex

  • A case of a young user of Thermadrene (SportPharma USA, Inc, Concord, Calif), an herbal remedy for weight loss, was studied [1].
  • METHODS: Clinical, pathological and follow-up data have been collected prospectively for all patients undergoing resection for colorectal cancer at Concord Hospital since 1971 [2].
  • METHODS: The study included all patients who had a potentially curative anterior resection with anastomosis for adenocarcinoma of the rectum between 1971 and 1991 at Concord Hospital. The data were collected prospectively, with complete follow-up for at least 5 years [3].
  • A single isolate (0.2%) was qnrA-positive (QnrA1 determinant) being a Salmonella serovar Concord carrying also the ESBL gene bla(CTX-M-15) [4].
  • A strain of Legionella pneumophila (designated Concord 3) was isolated from a postmortem lung specimen of a patient with pneumonia [5].

Psychiatry related information on Dominex

  • METHOD: The authors studied six thinking patterns known to characterize childhood posttraumatic stress disorder and four additional hypothesized patterns in 153 randomly selected children of Concord, N.H. (who watched the explosion on television) and Porterville, Calif. (who heard about it later) [6].
  • Women indicated that spirituality shapes and gives meaning to life, is expressed in one's being, knowing, and doing, and is experienced within caring connections with Self, Others, Nature, and Ultimate Other. Spirituality was related to an inner knowing and source of strength [7].
  • It aimed to increase the physical activity levels of women aged 20-50 years living in the Concord Local Government Area (LGA), an inner-western region of Sydney, Australia. A key feature of this intervention was a partnership between Concord Council (the local government) and the Central Sydney Health Promotion Unit (CSHPU) [8].

High impact information on Dominex

  • N-Nitroso(2-hydroxypropyl)(2-oxopropyl)amine (HPOP) is a complete pancreatic carcinogen in female hamsters at a dose of 210 mg/kg given via an Alzet 2001 pump implanted s.c. Ultimate carcinogenic metabolites of HPOP target DNA to yield 7-and O6-methylguanines (7-mGua, O6-mGua) and 7- and O6-hydroxypropylguanines (7-HpGua, O6-HpGua) [9].
  • Recently, we presented evidence that the extracellular part of VE cadherin, which consists of five homologous modules, associates as a Ca(2+)-dependent hexamer in solution (Legrand, P., Bibert, S., Jaquinod, M., Ebel, C., Hewat, E., Vincent, F., Vanbelle, C., Concord, E., Vernet, T., and Gulino, D. (2001) J. Biol. Chem. 276, 3581-3588) [10].
  • Vascular endothelial cadherin (VE-cadherin) is a transmembrane protein essential for endothelial cell monolayer integrity (Gulino, D., Delachanal, E., Concord, E., Genoux, Y., Morand, B., Valiron, M. O., Sulpice, E., Scaife, R., Alemany, M., and Vernet, T. (1998) J. Biol. Chem. 273, 29786-29793) [11].
  • RESULTS: Ultimate force (F(u)), displacement (D(u)), toughness (energy-to-fracture; U), and ultimate strain (epsilon(u)) increased significantly with exercise in myostatin-deficient mice but not in normal mice [12].
  • The Functional Image Analysis Contest (FIAC) 2005 dataset was analyzed using BrainVoyager QX [13].

Chemical compound and disease context of Dominex


Biological context of Dominex


Anatomical context of Dominex

  • Is Functional MR Imaging of Skeletal Muscle the Ultimate Tool for Assessment of Peripheral Arterial Occlusive Disease [21]?
  • Based on external landmarks, a predetermined length of 24-G epidural catheter (Concord Portex 20/24 microcatheter system) with stylet was passed into the epidural space through a 20-G intravenous catheter inserted through the sacrococcygeal ligament, and a radiograph of the abdomen and chest was obtained [22].
  • Helinx technology (Cerus Corp, Concord, CA) uses amotosalen HCl (S-59) and ultraviolet A (UVA) light in an ex vivo photochemical treatment (PCT) to inactivate viruses, bacteria, and leukocytes in platelet concentrates while preserving therapeutic function [23].
  • The results obtained showed that at high concentrations Fastac 10 EC has a clastogenic activity and/or damages the mitotic spindle, as manifested by a significant increase in the frequency of the micronucleated red blood cells [18].
  • The BOD POD air-displacement system (BOD POD body composition system; Life Measurement Instruments, Concord, CA, USA) is more precise than hydrodensitometry, is simple and rapid to operate (approximately 1 min measurements) and the results agree closely with those of hydrodensitometry (e.g. +/- 3.4% for estimation of body fat) [24].

Associations of Dominex with other chemical compounds


Gene context of Dominex

  • This study reports the critical care nurses' perceptions in the use of the SteriCath (Concord/Portex) CTSS focusing on hemodynamic stability, effectiveness of suctioning, patient safety and staff personnel exposure [30].
  • METHODS: A retrospective case review of patients with S. aureus bacteraemia in 1993 diagnosed at the Concord Repatriation General Hospital, Sydney. RESULTS: Of 104 cases reviewed, 32 were due to methicillin resistant S. aureus (MRSA), 73 were due to methicillin sensitive S. aureus (MSSA) and one was a dual infection [31].
  • We reviewed the principal findings from studies published between December 1995 and August 2001 that compared the BOD POD method (Life Measurement, Inc, Concord, CA) with reference methods and summarized factors contributing to the different study findings [32].
  • LC/MS/MS coupling was realized using a Phenomenex Synergy Max RP LC column (150 x 2 mm, 4 micro) in combination with a tandem mass spectrometer (API 2000, Applied Biosystems/MDS Sciex Concord) operating in positive and negative multiple reaction monitoring (MRM) mode with reserpine as internal standard [33].
  • Peak torque adjusted for age, body mass, and fat free mass (measured by whole body plethysmography; the Bod Pod; Life Measurement Instruments; Concord, CA) was significantly greater for controls than for MS for three of four lower body muscle groups tested [34].

Analytical, diagnostic and therapeutic context of Dominex

  • Genetic engineering patents. Contest in prospect over interferon rights [35].
  • Direct fluorescent-antibody and immunoelectrophoresis tests, using absorbed and unabsorbed reagents prepared to this and other strains of legionellae, indicated that the Concord 3 strain represents a new serogroup of L. pneumophila, serogroup 8 [5].
  • Despite exposure of the sheep to normal weathering, there was no significant difference in the concentration of alphacypermethrin between samples collected at day 1 or day 98 after treatment (P > 0.05) [36].
  • We have evaluated the fluoroscopic on-line portal imaging (OPI) system developed by Siemens (Beamview-1, Concord, CA, U.S.A.) in routine clinical radiotherapy, involving the treatment of 883 fields (559 patient set-ups for treatment) on 21 patients [37].
  • A retrospective study was made of 190 patients who had anterior resections of the rectum for carcinoma at Concord Hospital between 1971 and 1981 [38].


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  11. Self-assembly of the vascular endothelial cadherin ectodomain in a Ca2+-dependent hexameric structure. Legrand, P., Bibert, S., Jaquinod, M., Ebel, C., Hewat, E., Vincent, F., Vanbelle, C., Concord, E., Vernet, T., Gulino, D. J. Biol. Chem. (2001) [Pubmed]
  12. Increased muscle mass with myostatin deficiency improves gains in bone strength with exercise. Hamrick, M.W., Samaddar, T., Pennington, C., McCormick, J. J. Bone Miner. Res. (2006) [Pubmed]
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  14. Indoor residual spraying with alphacypermethrin controls malaria in Pakistan: a community-randomized trial. Rowland, M., Mahmood, P., Iqbal, J., Carneiro, I., Chavasse, D. Trop. Med. Int. Health (2000) [Pubmed]
  15. 52: PSEF 2006 Scientific Essay Contest Annual Bernard G. Sarnat, MD Junior Award, Basic Science - The Impact of Gradual Blood Flow Increase on Ischemia- Reperfusion Injury in the Rat Cremaster Microcirculation Model. Ozmen, S. Plast. Reconstr. Surg. (2006) [Pubmed]
  16. Comparison of the antioxidant effects of Concord grape juice flavonoids alpha-tocopherol on markers of oxidative stress in healthy adults. O'Byrne, D.J., Devaraj, S., Grundy, S.M., Jialal, I. Am. J. Clin. Nutr. (2002) [Pubmed]
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  18. Induction of micronuclei in tadpoles of Rana temporaria and Xenopus laevis by the pyrethroid Fastac 10 EC. Rudek, Z., Rozek, M. Mutat. Res. (1992) [Pubmed]
  19. Plaque radiotherapy for uveal melanoma: long-term visual outcome in 1106 consecutive patients. Shields, C.L., Shields, J.A., Cater, J., Gündüz, K., Miyamoto, C., Micaily, B., Brady, L.W. Arch. Ophthalmol. (2000) [Pubmed]
  20. Intraoperative complications of 1000 phacoemulsification procedures: a prospective study. Ng, D.T., Rowe, N.A., Francis, I.C., Kappagoda, M.B., Haylen, M.J., Schumacher, R.S., Alexander, S.L., Boytell, K.A., Lee, B.B. Journal of cataract and refractive surgery. (1998) [Pubmed]
  21. Is Functional MR Imaging of Skeletal Muscle the Ultimate Tool for Assessment of Peripheral Arterial Occlusive Disease? Forster, B.B. Radiology. (2006) [Pubmed]
  22. Thoracic epidural anesthesia via the caudal approach in children. Gunter, J.B., Eng, C. Anesthesiology (1992) [Pubmed]
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  24. New techniques in nutritional assessment: body composition methods. Elia, M., Ward, L.C. The Proceedings of the Nutrition Society. (1999) [Pubmed]
  25. Prospective study of the SI-40NB foldable silicone intraocular lens. Egan, C.A., Kottos, P.J., Francis, I.C., Kappagoda, M.B., Schumacher, R.S., Boytel, K.A., Haylen, M.J., Alexander, S. Journal of cataract and refractive surgery. (1996) [Pubmed]
  26. Quantitation of free and total amphotericin B in human biologic matrices by a liquid chromatography tandem mass spectrometric method. Lee, J.W., Petersen, M.E., Lin, P., Dressler, D., Bekersky, I. Therapeutic drug monitoring. (2001) [Pubmed]
  27. Trichinella nativa in a black bear from Plymouth, New Hampshire. Hill, D.E., Gamble, H.R., Zarlenga, D.S., Coss, C., Finnigan, J. Vet. Parasitol. (2005) [Pubmed]
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