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Chemical Compound Review

Maxivent     7-(1,3-dioxolan-2-ylmethyl)- 1,3-dimethyl...

Synonyms: Ansimar, Doxofilina, Ventax, DOXOFYLLINE, Dioxyfilline, ...
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Disease relevance of Maxivent


Psychiatry related information on Maxivent


High impact information on Maxivent


Chemical compound and disease context of Maxivent


Biological context of Maxivent

  • Effects of oral doxofylline on inflammatory changes and altered cell proliferation in chronic obstructive bronchitis [11].
  • Doxofylline increased forced expiratory volume in the first second of expiration compared with baseline as follows: +20% after 2 h (P less than 0.01); +31% after 4 h (P less than 0.01); and +13% after 6 h (NS) [12].
  • The present study presents clear evidence that the inability of doxofylline to cause positive inotropism can be linked to its inability to induce calcium movement from intracellular stores [13].
  • The effects on cardiac rhythm showed a progressive heart-rate reduction in the doxofylline group, whereas patients receiving theophylline presented an increase rate of beating [14].

Anatomical context of Maxivent


Associations of Maxivent with other chemical compounds


Analytical, diagnostic and therapeutic context of Maxivent


  1. The effect of intravenous doxofylline or aminophylline on gastric secretion in duodenal ulcer patients. Lazzaroni, M., Grossi, E., Porro, G.B. Aliment. Pharmacol. Ther. (1990) [Pubmed]
  2. Doxofylline and respiratory mechanics. Short-term effects in mechanically ventilated patients with airflow obstruction and respiratory failure. Poggi, R., Brandolese, R., Bernasconi, M., Manzin, E., Rossi, A. Chest (1989) [Pubmed]
  3. Doxofylline exerts a prophylactic effect against bronchoconstriction and pleurisy induced by PAF. Franzone, J.S., Cirillo, R., Biffignandi, P. Eur. J. Pharmacol. (1989) [Pubmed]
  4. Doxofylline: a new generation xanthine bronchodilator devoid of major cardiovascular adverse effects. Dini, F.L., Cogo, R. Current medical research and opinion. (2001) [Pubmed]
  5. Oral doxophylline in patients with chronic obstructive pulmonary disease. Villani, F., De Maria, P., Ronchi, E., Galimberti, M. International journal of clinical pharmacology and therapeutics. (1997) [Pubmed]
  6. Doxofylline in rat brain in relation to locomotor activity. Cravanzola, C., Reboani, M.C., Grosa, G., Franzone, J.S. Drug Metab. Dispos. (1989) [Pubmed]
  7. Non-extraction HPLC method for simultaneous measurement of dyphylline and doxofylline in serum. Tagliaro, F., Dorizzi, R., Frigerio, A., Marigo, M. Clin. Chem. (1990) [Pubmed]
  8. Respiratory system mechanics in the early phase of acute respiratory failure due to severe kyphoscoliosis. Conti, G., Rocco, M., Antonelli, M., Bufi, M., Tarquini, S., Lappa, A., Gasparetto, A. Intensive care medicine. (1997) [Pubmed]
  9. Choosing a negative pressure ventilation pump: are there any important differences? Smith, I.E., King, M.A., Shneerson, J.M. Eur. Respir. J. (1995) [Pubmed]
  10. Treatment of reversible chronic airways obstruction with doxofylline compared with slow-release theophylline: a double-blind, randomized, multicentre trial. Melillo, G., Balzano, G., Jodice, F., De Felice, A., Campisi, V., Capone, M., Di Filippo, A., Foddai, G., Franzone, J.S., Grossi, E. International journal of clinical pharmacology research. (1989) [Pubmed]
  11. Effects of oral doxofylline on inflammatory changes and altered cell proliferation in chronic obstructive bronchitis. Cogo, R., Castronuovo, A. European review for medical and pharmacological sciences. (2000) [Pubmed]
  12. Comparison of intravenously administered doxofylline and placebo for the treatment of severe acute airways obstruction. Dolcetti, A., Osella, D., De Filippis, G., Carnuccio, C., Grossi, E. J. Int. Med. Res. (1988) [Pubmed]
  13. Doxofylline differs from methylxanthines in its movement of cytosolic calcium. Franzone, J.S., Cirillo, R., Reboani, M.C. International journal of tissue reactions. (1991) [Pubmed]
  14. Methylxanthine drug therapy in chronic heart failure associated with hypoxaemia: double-blind placebo-controlled clinical trial of doxofylline versus theophylline and bamifylline. Dini, F.L., Pasini, G., Cortellini, G., Cani, E., Bettini, R., Garagnani, A., Gobbi, G., Greco, A., Onorato, G., Pasini, P. International journal of clinical pharmacology research. (1993) [Pubmed]
  15. Metabolism of doxophylline by rat liver microsomes. Grosa, G., Franzone, J.S., Biglino, G. Drug Metab. Dispos. (1986) [Pubmed]
  16. Doxofylline and theophylline are xanthines with partly different mechanisms of action in animals. Franzone, J.S., Cirillo, R., Barone, D. Drugs under experimental and clinical research. (1988) [Pubmed]
  17. Doxofylline, an antiasthmatic drug lacking affinity for adenosine receptors. Cirillo, R., Barone, D., Franzone, J.S. Archives internationales de pharmacodynamie et de thérapie. (1988) [Pubmed]
  18. Oral and intravenous pharmacokinetic profiles of doxofylline in patients with chronic bronchitis. Bologna, E., Laganà, A., Terracino, D., Bolignari, P., Biffignandi, P. J. Int. Med. Res. (1990) [Pubmed]
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