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MeSH Review

Respiratory Mechanics

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Disease relevance of Respiratory Mechanics


High impact information on Respiratory Mechanics

  • In 5LO-deficient mice, the HVT-induced increase of pulmonary vascular permeability and worsening of respiratory mechanics were markedly attenuated, systemic oxygenation was preserved, and survival increased [6].
  • In vivo (lung resistive and viscoelastic pressures and static elastance) and in vitro (tissue resistance, elastance, and hysteresivity) respiratory mechanics were analyzed 1 and 30 days after saline (control) or paraquat (P [10 and 25 mg/kg intraperitoneally]) injection in rats [7].
  • Patients with COPD have derangements in respiratory mechanics that may cause them to stop exercising before the exercising limb muscles reach their functional limits [8].
  • Because bronchodilators may decrease airway resistance, we also investigated the effect of nebulized salbutamol on EFL, PEEPi, and respiratory mechanics in these patients, and in seven patients we measured the latter variables in the supine position as well [9].
  • Respiratory mechanics were also measured for 60 min in another group of seven patients with COPD who received four puffs of albuterol [10].

Chemical compound and disease context of Respiratory Mechanics


Biological context of Respiratory Mechanics

  • Therefore the authors studied respiratory mechanics during xenon and nitrous oxide (N2O) anesthesia before and during methacholine-induced bronchoconstriction [14].
  • In an attempt to differentiate between these two possible mechanisms, we obtained measurements of hemodynamics, respiratory mechanics, and O2 consumption (VO2) in nine asymptomatic adult ragweed asthmatics before and after inhalation challenge with either ragweed extract or methacholine [15].
  • Aim of our study has been to evaluate the potential beneficial effects of the pre-treatment with low doses of ASA on gas exchange, hemodynamics, respiratory mechanics, prostanoids and lung histology in OA-induced lung injury in sheep [16].
  • No significant changes in respiratory mechanics, oxygen consumption, carbon dioxide production, resting energy expenditure, serum substrates, liver function, or nitrogen balance were noted by the addition of 500 kcal of lipid emulsion to dextrose calories sufficient to meet energy requirements [17].
  • CONCLUSIONS: In mechanically ventilated patients with and without COPD, a time constant can well be calculated from the expiratory flow-volume curve for the last 75% of tidal volume, gives a good estimation of respiratory mechanics, and is easy to obtain at the bedside [18].

Anatomical context of Respiratory Mechanics


Associations of Respiratory Mechanics with chemical compounds


Gene context of Respiratory Mechanics

  • The patterns of change in respiratory mechanics were similar in both SP-D (+/+) and (-/-) groups [26].
  • OBJECTIVES: The purpose of this study was to investigate the VEGF, bFGF, TGF-beta(1) mRNA levels in the human diaphragm of normal subjects and patients with altered respiratory mechanics [27].
  • CONCLUSION: Fast GRE MR imaging can be reliably used to demonstrate diaphragmatic motion and may prove useful in the investigation of normal and abnormal respiratory mechanics [28].
  • The alterations of the nanoscopic structures of phospholipid films by SP-B provide the structural framework for the protein simultaneously sustaining structural stability as well as dynamical flexibility in surfactant films at the extreme conditions imposed by the respiratory mechanics [29].
  • Effect of surgical repair on respiratory mechanics in congenital diaphragmatic hernia [30].

Analytical, diagnostic and therapeutic context of Respiratory Mechanics


  1. Effect of salbutamol on respiratory mechanics in bronchiolitis. Hughes, D.M., Lesouëf, P.N., Landau, L.I. Pediatr. Res. (1987) [Pubmed]
  2. Respiratory response and pharmacokinetics of intravenous salbutamol in infants with bronchopulmonary dysplasia. Kirpalani, H., Koren, G., Schmidt, B., Tan, Y., Santos, R., Soldin, S. Crit. Care Med. (1990) [Pubmed]
  3. Dose-response effects and time course of effects of inhaled fenoterol on respiratory mechanics and arterial oxygen tension in mechanically ventilated patients with chronic airflow obstruction. Bernasconi, M., Brandolese, R., Poggi, R., Manzin, E., Rossi, A. Intensive care medicine. (1990) [Pubmed]
  4. Doxofylline and respiratory mechanics. Short-term effects in mechanically ventilated patients with airflow obstruction and respiratory failure. Poggi, R., Brandolese, R., Bernasconi, M., Manzin, E., Rossi, A. Chest (1989) [Pubmed]
  5. Effects of helium-oxygen on respiratory mechanics, gas exchange, and ventilation-perfusion relationships in a porcine model of stable methacholine-induced bronchospasm. Watremez, C., Liistro, G., deKock, M., Roeseler, J., Clerbaux, T., Detry, B., Reynaert, M., Gianello, P., Jolliet, P. Intensive care medicine. (2003) [Pubmed]
  6. 5-Lipoxygenase deficiency prevents respiratory failure during ventilator-induced lung injury. Caironi, P., Ichinose, F., Liu, R., Jones, R.C., Bloch, K.D., Zapol, W.M. Am. J. Respir. Crit. Care Med. (2005) [Pubmed]
  7. Effect of corticosteroid on lung parenchyma remodeling at an early phase of acute lung injury. Rocco, P.R., Souza, A.B., Faffe, D.S., Pássaro, C.P., Santos, F.B., Negri, E.M., Lima, J.G., Contador, R.S., Capelozzi, V.L., Zin, W.A. Am. J. Respir. Crit. Care Med. (2003) [Pubmed]
  8. Quadriceps fatigue after cycle exercise in patients with chronic obstructive pulmonary disease. Jeffery Mador, M., Kufel, T.J., Pineda, L. Am. J. Respir. Crit. Care Med. (2000) [Pubmed]
  9. Expiratory flow limitation and intrinsic positive end-expiratory pressure at zero positive end-expiratory pressure in patients with adult respiratory distress syndrome. Koutsoukou, A., Armaganidis, A., Stavrakaki-Kallergi, C., Vassilakopoulos, T., Lymberis, A., Roussos, C., Milic-Emili, J. Am. J. Respir. Crit. Care Med. (2000) [Pubmed]
  10. Dose-response to bronchodilator delivered by metered-dose inhaler in ventilator-supported patients. Dhand, R., Duarte, A.G., Jubran, A., Jenne, J.W., Fink, J.B., Fahey, P.J., Tobin, M.J. Am. J. Respir. Crit. Care Med. (1996) [Pubmed]
  11. Effect of dexamethasone on tracheobronchial aspirate fluid cytology and pulmonary mechanics in preterm infants. Vento, G., Matassa, P.G., Zecca, E., Tortorolo, L., Martelli, M., De Carolis, M.P., Maggio, L., Zini, G., D'Onofrio, G., Valentini, S., Romagnoli, C. Pharmacology (2004) [Pubmed]
  12. The effect of doxapram-induced hyperventilation on respiratory mechanics in horses. Aguilera-Tejero, E., Pascoe, J.R., Smith, B.L., Woliner, M.J. Res. Vet. Sci. (1997) [Pubmed]
  13. Acute changes in respiratory mechanics after pyridostigmine injection in patients with myasthenia gravis. De Troyer, A., Borenstein, S. Am. Rev. Respir. Dis. (1980) [Pubmed]
  14. Respiratory mechanics during xenon anesthesia in pigs: comparison with nitrous oxide. Calzia, E., Stahl, W., Handschuh, T., Marx, T., Fröba, G., Bäder, S., Georgieff, M., Radermacher, P. Anesthesiology (1999) [Pubmed]
  15. Effects of induced bronchoconstriction on pulmonary blood flow. Olgiati, R., Wanner, A. J. Appl. Physiol. (1986) [Pubmed]
  16. Aspirin effect on early and late changes in acute lung injury in sheep. Chelucci, G.L., Boncinelli, S., Marsili, M., Lorenzi, P., Allegra, A., Linden, M., Chelucci, A., Merciai, V., Cresci, F., Rostagno, C. Intensive care medicine. (1993) [Pubmed]
  17. Metabolic and respiratory effects of continuous and discontinuous lipid infusions. Occurrence in excess of resting energy expenditure. Abbott, W.C., Grakauskas, A.M., Bistrian, B.R., Rose, R., Blackburn, G.L. Archives of surgery (Chicago, Ill. : 1960) (1984) [Pubmed]
  18. Expiratory time constants in mechanically ventilated patients with and without COPD. Lourens, M.S., van den Berg, B., Aerts, J.G., Verbraak, A.F., Hoogsteden, H.C., Bogaard, J.M. Intensive care medicine. (2000) [Pubmed]
  19. Continuous extrapleural intercostal nerve block after pleurectomy. Mozell, E.J., Sabanathan, S., Mearns, A.J., Bickford-Smith, P.J., Majid, M.R., Zografos, G. Thorax (1991) [Pubmed]
  20. Respiratory mechanical properties during fentanyl and alfentanil anaesthesia. Ruiz Neto, P.P., Auler Júnior, J.O. Canadian journal of anaesthesia = Journal canadien d'anesthésie. (1992) [Pubmed]
  21. Exercise in patients with chronic obstructive pulmonary disease. Stewart, R.I. S. Afr. Med. J. (1985) [Pubmed]
  22. The effects of CO2 on respiratory mechanics in anesthetized paralyzed humans. D'Angelo, E., Calderini, I.S., Tavola, M. Anesthesiology (2001) [Pubmed]
  23. Prevention of methacholine-induced changes in respiratory mechanics in piglets: a comparison of sevoflurane and halothane. Habre, W., Wildhaber, J.H., Sly, P.D. Anesthesiology (1997) [Pubmed]
  24. Failure of enhancement by labetalol of bronchopulmonary effects of histamine in guinea-pigs: independence of alpha-adrenoceptor antagonism. Clerici, C., Harf, A., Macquin-Mavier, I. Br. J. Pharmacol. (1987) [Pubmed]
  25. Meconium aspiration produces airway hyperresponsiveness and eosinophilic inflammation in a murine model. Khan, A.M., Elidemir, O., Epstein, C.E., Lally, K.P., Xue, H., Blackburn, M., Larsen, G.L., Colasurdo, G.N. Am. J. Physiol. Lung Cell Mol. Physiol. (2002) [Pubmed]
  26. In vivo measurements of changes in respiratory mechanics with age in mice deficient in surfactant protein D. Collins, R.A., Ikegami, M., Korfhagen, T.R., Whitsett, J.A., Sly, P.D. Pediatr. Res. (2003) [Pubmed]
  27. Vascular-specific growth factor mRNA levels in the human diaphragm. Alexopoulou, C., Mitrouska, I., Arvanitis, D., Tzanakis, N., Chalkiadakis, G., Melissas, J., Zervou, M., Siafakas, N. Respiration; international review of thoracic diseases. (2005) [Pubmed]
  28. Diaphragmatic motion: fast gradient-recalled-echo MR imaging in healthy subjects. Gierada, D.S., Curtin, J.J., Erickson, S.J., Prost, R.W., Strandt, J.A., Goodman, L.R. Radiology. (1995) [Pubmed]
  29. Effect of pulmonary surfactant protein SP-B on the micro- and nanostructure of phospholipid films. Cruz, A., Vázquez, L., Vélez, M., Pérez-Gil, J. Biophys. J. (2004) [Pubmed]
  30. Effect of surgical repair on respiratory mechanics in congenital diaphragmatic hernia. Sakai, H., Tamura, M., Hosokawa, Y., Bryan, A.C., Barker, G.A., Bohn, D.J. J. Pediatr. (1987) [Pubmed]
  31. An evaluation of the Laryngeal Tube during general anesthesia using mechanical ventilation. Gaitini, L.A., Vaida, S.J., Somri, M., Kaplan, V., Yanovski, B., Markovits, R., Hagberg, C.A. Anesth. Analg. (2003) [Pubmed]
  32. The effects of nebulized salbutamol, external positive end-expiratory pressure, and their combination on respiratory mechanics, hemodynamics, and gas exchange in mechanically ventilated chronic obstructive pulmonary disease patients. Tzoufi, M., Mentzelopoulos, S.D., Roussos, C., Armaganidis, A. Anesth. Analg. (2005) [Pubmed]
  33. Acute exacerbations in patients with COPD: predictors of need for mechanical ventilation. Vitacca, M., Clini, E., Porta, R., Foglio, K., Ambrosino, N. Eur. Respir. J. (1996) [Pubmed]
  34. Effects of sedation, anesthesia, and endotracheal intubation on respiratory mechanics in adult horses. Tomasic, M., Mann, L.S., Soma, L.R. Am. J. Vet. Res. (1997) [Pubmed]
  35. Aerosolized albuterol improves airway reactivity in infants with acute respiratory failure from respiratory syncytial virus. Derish, M., Hodge, G., Dunn, C., Ariagno, R. Pediatr. Pulmonol. (1998) [Pubmed]
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