Disease relevance of NMUR2

• We screened the NMU2R gene in 96 patients with severe early-onset obesity [1].
• Neuromedin U 2 receptor (NMU2R) plays important roles for the regulation of food intake and body weight [2].
• However, the Tg receptor positive fraction was readily activated by EBV to synthesize Tg antibody with a specific activity 4-10 times higher than that secreted by unfractionated lymphocytes [3].

Psychiatry related information on NMUR2

• Screening of neuromedin U2 receptor (NMU2R) ligands may be very useful to treat obesity for the reason that centrally administered neuromedin U affects feeding behavior, energy expenditure, and pituitary [4].

High impact information on NMUR2

• TGR-1 mRNA was primarily expressed in the uterus, suggesting that TGR-1 mediates the contractile activity of neuromedin U in this tissue [5].
• The rationale for the occurrence and distribution of the TR and TGR1 repeats on the tomato chromosomes are discussed [6].
• The majority of the telomeres consisted of a TR and a TGR1 region separated by a spacer [6].
• Expression of NMS and NMU2R genes was detected at the hypothalamus along postnatal development, with significant fluctuations of their relative levels (maximum at prepubertal stage and adulthood) [7].
• In adult females, hypothalamic expression of NMS (which was confined to suprachiasmatic nucleus) and NMU2R significantly varied during the estrous cycle (maximum at proestrus) and was lowered after ovariectomy and enhanced after progesterone supplementation [7].

Biological context of NMUR2

• Expression of NMU1R and NMU2R mRNA in rat and human tissue was determined using semi-quantitative reverse-transcription polymerase chain reaction [8].
• In summary, we have identified two markedly different isoforms of the NMU-2 receptor, presumably arising through an ancient and complex mutational event; no genetic associations between this haplotype and obesity-related traits were, however, discerned [1].
• These three bands appear to represent the proteins encoded by FM2 (the 73 kDa band), FM1 (the 71 kDa band), and FM4 (the 62 kDa band) since the apparent molecular weights are close to their theoretical weights of the predicted amino acid sequences [9].
• In this study, we have identified four alternatively spliced RAD17 RNAs, FM1, FM2, FM3, and FM4, which are produced through alternative splicing within the first 300 base-pairs of the coding region [9].
• A cell-based reporter gene assay has been developed and used for the screening of human NMU2R agonist [2].

Anatomical context of NMUR2

• NMU1 and NMU2 receptor transcription was detected in all tissues; transcription of both receptors was similar in gallbladder, but NMU1 receptor transcription was predominant in the sigmoid colon and LSV [10].
• Localisation of NMU1R and NMU2R in human and rat central nervous system and effects of neuromedin-U following central administration in rats [8].
• Both NMU and its receptors, NMUR1 and NMUR2, were expressed in the pituitary gland [11].
• Here, we have developed a stable cell line of neuromedin U2 receptor (NMU2R) to screen for its agonist [4].
• We now report an investigation into the requirements for the isolation of Tg receptor positive (TgR+) B cells capable of being stimulated by PWM [12].

Associations of NMUR2 with chemical compounds

• We found that neuromedin U specifically and clearly elevated the extracellular acidification rates, arachidonic acid metabolite release, and intracellular Ca(2+) mobilization in Chinese hamster ovary cells expressing TGR-1 [5].
• The experimental results demonstrate that icariin, isolated from Herba epimedii, was a strong agonist for NMU2R, which could selectively activate NMU2R, but not M1R, MC4R, and negative cell lines [4].
• We have investigated whether a palmitate conjugate of a human monoclonal antibody specific for thyroglobulin (TG) could function as a surrogate TG receptor on blood mononuclear cells separated into fractions enriched for T cells or depleted of T cells (non-T cells) [13].

Analytical, diagnostic and therapeutic context of NMUR2

• In this report, we describe detailed mapping of NMU2R mRNA expression in the rat brain by in situ hybridization [14].
• The molecular and cytological organization of the telomeric repeat (TR) and the subtelomeric repeat (TGR1) of tomato were investigated by fluorescence in situ hybridization (FISH) techniques [6].
• To understand the molecular basis of the NMU2R regulation of food intake and body weight, we examined the expression of a number of key genes in hypothalamus and adipose tissues after oral administration of EUK2010 in mice [2].

References