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Chemical Compound Review

Mydocalm     2-methyl-1-(4-methylphenyl)- 3-(1...

Synonyms: Mydetone, Menopatol, Mideton, Mydeton, Tolperisona, ...
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Disease relevance of Mydeton


Psychiatry related information on Mydeton


High impact information on Mydeton

  • Isoform-specific cytochrome P450 (P450) inhibitors, inhibitory antibodies, and experiments with recombinant P450s pointed to CYP2D6 as the prominent enzyme in tolperisone metabolism [7].
  • Therefore, it was concluded that tolperisone undergoes P450-dependent and P450-independent microsomal biotransformations to the same extent [7].
  • Identification of metabolic pathways involved in the biotransformation of tolperisone by human microsomal enzymes [7].
  • In the present study, head-dipping and place-learning (forms of nose-poking and spatial-preference tasks, respectively) paradigms with lateral hypothalamus stimulation were systematically analyzed using C57BL/6 mice in the presence and absence of two motor-deficit-inducing drugs: tolperisone and harmaline [8].
  • Sedative effects of single and repeated doses of 50 mg and 150 mg tolperisone hydrochloride (Mydocalm), a centrally active muscle-relaxing agent, were evaluated in a placebo-controlled double-blind clinical trial [6].

Biological context of Mydeton


Anatomical context of Mydeton


Associations of Mydeton with other chemical compounds


Analytical, diagnostic and therapeutic context of Mydeton


  1. Efficacy and tolerance of repeated oral doses of tolperisone hydrochloride in the treatment of painful reflex muscle spasm: results of a prospective placebo-controlled double-blind trial. Pratzel, H.G., Alken, R.G., Ramm, S. Pain (1996) [Pubmed]
  2. Tolperisone-type drugs inhibit spinal reflexes via blockade of voltage-gated sodium and calcium channels. Kocsis, P., Farkas, S., Fodor, L., Bielik, N., Thán, M., Kolok, S., Gere, A., Csejtei, M., Tarnawa, I. J. Pharmacol. Exp. Ther. (2005) [Pubmed]
  3. A randomized, double-blind, placebo-controlled study of the efficacy and safety of tolperisone in spasticity following cerebral stroke. Stamenova, P., Koytchev, R., Kuhn, K., Hansen, C., Horvath, F., Ramm, S., Pongratz, D. Eur. J. Neurol. (2005) [Pubmed]
  4. Reversible adrenergic alpha-receptor blocking action of 2,4'-dimethyl-3-piperidino-propiophenone (tolperisone). Furuta, Y., Yoshikawa, A. Jpn. J. Pharmacol. (1976) [Pubmed]
  5. Anaphylactic reactions to tolperisone (Mydocalm). Ribi, C., Vermeulen, C., Hauser, C. Swiss medical weekly : official journal of the Swiss Society of Infectious Diseases, the Swiss Society of Internal Medicine, the Swiss Society of Pneumology. (2003) [Pubmed]
  6. Evaluation of sedative effects of single and repeated doses of 50 mg and 150 mg tolperisone hydrochloride. Results of a prospective, randomized, double-blind, placebo-controlled trial. Dulin, J., Kovács, L., Ramm, S., Horvath, F., Ebeling, L., Kohnen, R. Pharmacopsychiatry (1998) [Pubmed]
  7. Identification of metabolic pathways involved in the biotransformation of tolperisone by human microsomal enzymes. Dalmadi, B., Leibinger, J., Szeberényi, S., Borbás, T., Farkas, S., Szombathelyi, Z., Tihanyi, K. Drug Metab. Dispos. (2003) [Pubmed]
  8. Comparison of two intracranial self-stimulation (ICSS) paradigms in C57BL/6 mice: head-dipping and place-learning. Ikeda, K., Moss, S.J., Fowler, S.C., Niki, H. Behav. Brain Res. (2001) [Pubmed]
  9. Gas-liquid chromatographic method for the determination of tolperisone in human plasma: pharmacokinetic and comparative bioavailability studies. Miskolczi, P., Vereczkey, L., Frenkl, R. Journal of pharmaceutical and biomedical analysis. (1987) [Pubmed]
  10. Mydocalm treatment of muscular and vascular complaints accompanying climacterics. Sásdi, A. Therapia Hungarica (English edition) (1992) [Pubmed]
  11. Tolperisone: evaluation of the lidocaine-like activity by molecular modeling. Fels, G. Arch. Pharm. (Weinheim) (1996) [Pubmed]
  12. Effects of some centrally acting muscle relaxants on spinal root potentials: a comparative study. Farkas, S., Tarnawa, I., Berzsenyi, P. Neuropharmacology (1989) [Pubmed]
  13. Tolperisone--a novel modulator of ionic currents in myelinated axons. Hinck, D., Koppenhöfer, E. Gen. Physiol. Biophys. (2001) [Pubmed]
  14. Comparative characterisation of the centrally acting muscle relaxant RGH-5002 and tolperisone and of lidocaine based on their effects on rat spinal cord in vitro. Farkas, S., Kocsis, P., Bielik, N. Neurobiology (Budapest, Hungary) (1997) [Pubmed]
  15. Muscle relaxant action of dantrolene sodium in rats. Saito, S., Harada, M., Yamamoto, M., Takagi, H., Saito, K., Konno, Y. Res. Commun. Chem. Pathol. Pharmacol. (1993) [Pubmed]
  16. Determination of tolperisone enantiomers in plasma and their disposition in rats. Yokoyama, T., Fukuda, K., Mori, S., Ogawa, M., Nagasawa, K. Chem. Pharm. Bull. (1992) [Pubmed]
  17. HPLC determination of tolperisone in human plasma. Bae, J.W., Park, Y.S., Sohn, U.D., Myung, C.S., Ryu, B.K., Jang, C.G., Lee, S.Y. Arch. Pharm. Res. (2006) [Pubmed]
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