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Chemical Compound Review

cephalothin     sodium(6R,7S)-3- (acetyloxymethyl)-8-oxo-7...

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Disease relevance of Cefalotin


High impact information on Cefalotin


Chemical compound and disease context of Cefalotin

  • In a study of experimentally induced open tibial or femoral fractures in rats, after either closing or leaving the wounds open, the animals were given: no antibiotic, cephalothin (Keflin), or penicillin [11].

Biological context of Cefalotin


Anatomical context of Cefalotin

  • Under the conditions of this study, which included intravenous administration of cephalothin sodium preoperatively, intraoperatively, and postoperatively, the small intestinal transudate did not harbor enteric bacteria [14].
  • In a study of the inflammatory potential of the filterable residue of sodium cephalothin, we have found a tissue-specific reaction with venous endothelium but not with cutaneous or subcutaneous tissues [15].
  • A prospective double-blind study, using Keflex and Keflin in theraputic doses,was undertaken to elucidate more clearly the effect upon morbidity in vaginal hysterectomy.Cultures were taken form a catheterized urine specimen and the cervix of all patients before surgery [16].
  • AP was induced in dogs by injection of autologous bile into the pancreatic duct, and in rats by controlled infusion of artificial bile containing Na-taurochlorate, Keflin, and trypsin into the cannulated bile duct [17].

Associations of Cefalotin with other chemical compounds


Analytical, diagnostic and therapeutic context of Cefalotin


  1. Nephrotoxicity associated with cephalothin administration. Carling, P.C., Idelson, B.A., Casano, A.A., Alexander, E.A., McCabe, W.R. Arch. Intern. Med. (1975) [Pubmed]
  2. Nephrotoxicity of combined cephalothin-gentamicin regimen. Cabanillas, F., Burgos, R.C., Rodríguez, C., Baldizón, C. Arch. Intern. Med. (1975) [Pubmed]
  3. Toxicologic evaluation of cefamandole nafate in laboratory animals. Wold, J.S., Welles, J.S., Owen, N.V., Gibson, W.R., Morton, D.M. J. Infect. Dis. (1978) [Pubmed]
  4. New techniques for interruption of gastroesophageal venous blood flow. Pereiras, R., Viamonte, M., Russell, E., LePage, J., White, P., Hutson, D. Radiology. (1977) [Pubmed]
  5. Acute interstitial nephritis. Drago, J.R., Rohner, T.J., Sanford, E.J., Engle, J., Schoolwerth, A. J. Urol. (1976) [Pubmed]
  6. Antibiotic activity in surgical incisions. The basis of prophylaxis in selected operations. Polk, H.C., Trachtenberg, L., Finn, M.P. JAMA (1980) [Pubmed]
  7. Reversible nephrotoxicity associated with cephalothin therapy. Pasternak, D.P., Stephens, B.G. Arch. Intern. Med. (1975) [Pubmed]
  8. The use of cephalothin sodium (keflin) as the prophylactic antibiotic for open heart surgery. Bain, W.H., McGeachie, J., Lindsay, G., Underwood, J. J. Antimicrob. Chemother. (1977) [Pubmed]
  9. Crystallization of cephalothin sodium during lyophilization from tert-butyl alcohol-water cosolvent system. Telang, C., Suryanarayanan, R. Pharm. Res. (2005) [Pubmed]
  10. Single-dose and multidose prophylaxis in vaginal hysterectomy: a comparison of sodium cephalothin and metronidazole. Hamod, K.A., Spence, M.R., Rosenshein, N.B., Dillon, M.B. Am. J. Obstet. Gynecol. (1980) [Pubmed]
  11. The effect of antibiotics, primary and secondary closure on clostridial contaminated open fracture wounds in rats. Patzakis, M.J., Dorr, L.D., Hammond, W., Ivler, D. The Journal of trauma. (1978) [Pubmed]
  12. Serum and dialyzate concentrations of intraperitoneal cephalothin in patients undergoing continuous ambulatory peritoneal dialysis. Münch, R., Steurer, J., Lüthy, R., Siegenthaler, W., Kuhlmann, U. Clin. Nephrol. (1983) [Pubmed]
  13. Effect of prophylactic systemic administration of cephalothin in colorectal surgery. Kjellgren, K., Sellström, H. Acta chirurgica Scandinavica. (1977) [Pubmed]
  14. Sterility of intestinal transudate during aortic reconstructive procedures. Russell, H.E., Barnes, R.W., Baker, W.H. Archives of surgery (Chicago, Ill. : 1960) (1975) [Pubmed]
  15. Inflammatory potential of foreign particulates in parenteral drugs. Dorris, G.G., Bivins, B.A., Rapp, R.P., Weiss, D.L., DeLuca, P.P., Ravin, M.B. Anesth. Analg. (1977) [Pubmed]
  16. The prophylactic use of Keflex and Keflin in vaginal hysterectomy. Bivens, M.D., Neufeld, J., McCarty, W.D. Am. J. Obstet. Gynecol. (1975) [Pubmed]
  17. Mechanism of calcium and magnesium translocation in acute pancreatitis: a temporal correlation between hypocalcemia and membrane-mediated excessive intracellular calcium accumulation in soft tissues. Bhattacharya, S.K., Crawford, A.J., Pate, J.W., Clemens, M.G., Chaudry, I.H. Magnesium. (1988) [Pubmed]
  18. The simultaneous quantitative determination of cephalothin and cefazolin in serum by high pressure liquid chromatography. Wold, J.S., Turnipseed, S.A. Clin. Chim. Acta (1977) [Pubmed]
  19. Differences in immune responses to antibiotics in three guinea-pig strains. Aida, T., Ishikawa, N., Shinkai, K. The Journal of toxicological sciences. (1997) [Pubmed]
  20. Comparative study of cefamandole versus cephalothin as antibiotic prophylaxis for open heart surgery. Mészáros, R., Windisch, M., Koltai, C., Lukács, L. Cor et vasa. (1986) [Pubmed]
  21. Allergic reaction to transfused cephalothin antibody. Branch, D.R., Gifford, H. JAMA (1979) [Pubmed]
  22. Quantitative antibiotic sensitivity determinations of Staphylococcus aureus isolated from eye cultures. Kim, H.B., Okumoto, M., Smolin, G. Arch. Ophthalmol. (1977) [Pubmed]
  23. Quantitative crystallinity determinations for beta-lactam antibiotics by solution calorimetry: correlations with stability. Pikal, M.J., Lukes, A.L., Lang, J.E., Gaines, K. Journal of pharmaceutical sciences. (1978) [Pubmed]
  24. Escherichia coli bacteremia associated with hypertrophic osteodystrophy in a dog. Schulz, K.S., Payne, J.T., Aronson, E. J. Am. Vet. Med. Assoc. (1991) [Pubmed]
  25. Freeze-drying of cephalothin sodium: granularly agglomerated crystallization during freezing. II. Suzuki, Y., Takeda, T., Inazu, K., Sakamoto, T. Biol. Pharm. Bull. (1993) [Pubmed]
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