Disease relevance of Cefalotin

• Variable degrees of acute renal failure developed in three patients receiving therapy with cephalothin sodium [1].
• Two patients developed acute tubular necrosis, characterized clinically by acute oliguric renal failure, while they were receiving a combination of cephalothin sodium and gentamicin sulfate therapy [2].
• The acute toxicity of cefamandole after intravenous or subcutaneous administration was similar to that of cephalothin sodium [3].
• Enlarged gastroesophageal veins were successfully obliterated in 41 patients using embolization with modified autogenous clots and/or Gelfoam, balloon occlusion, iatrogenic perivenous hematoma, sclerosing agents (Sotradecol and Keflin), or a combination of these methods [4].
• The clinical course of a patient after excessive sodium cephalothin administration suggested allergic interstitial nephritis and implicates this drug as an etiologic agent [5].

High impact information on Cefalotin

• Controlled clinical trials now indicate that cephalothin sodium may not be effective in this role, whereas cephaloridine and cefazolin sodium have been beneficial [6].
• A 53-year-old man with scalp cellulitis developed acute renal failure after sodium cephalothin therapy [7].
• The use of cephalothin sodium (keflin) as the prophylactic antibiotic for open heart surgery [8].
• Crystallization of cephalothin sodium during lyophilization from tert-butyl alcohol-water cosolvent system [9].
• Single-dose and multidose prophylaxis in vaginal hysterectomy: a comparison of sodium cephalothin and metronidazole [10].

Chemical compound and disease context of Cefalotin

• In a study of experimentally induced open tibial or femoral fractures in rats, after either closing or leaving the wounds open, the animals were given: no antibiotic, cephalothin (Keflin), or penicillin [11].

Biological context of Cefalotin

• The pharmacokinetics of cephalothin sodium were studied in seven patients with chronic renal failure undergoing continuous ambulatory peritoneal dialysis [12].
• The effect of standardized prophylactic treatment with systemically administered cephalothin (Keflin) was studied in a series of 120 consecutive patients in whom elective colorectal surgery was planned [13].

Anatomical context of Cefalotin

• Under the conditions of this study, which included intravenous administration of cephalothin sodium preoperatively, intraoperatively, and postoperatively, the small intestinal transudate did not harbor enteric bacteria [14].
• In a study of the inflammatory potential of the filterable residue of sodium cephalothin, we have found a tissue-specific reaction with venous endothelium but not with cutaneous or subcutaneous tissues [15].
• A prospective double-blind study, using Keflex and Keflin in theraputic doses,was undertaken to elucidate more clearly the effect upon morbidity in vaginal hysterectomy.Cultures were taken form a catheterized urine specimen and the cervix of all patients before surgery [16].
• AP was induced in dogs by injection of autologous bile into the pancreatic duct, and in rats by controlled infusion of artificial bile containing Na-taurochlorate, Keflin, and trypsin into the cannulated bile duct [17].

Associations of Cefalotin with other chemical compounds

• The prophylactic use of Keflex and Keflin in vaginal hysterectomy [16].
• An HPLC procedure has been developed which permits the simultaneous quantitative determination of cefazolin sodium and cephalothin sodium in serum [18].
• The present experiments were undertaken to clarify the differences in humoral immune response to two beta-lactam antibiotics, benzylpenicillin potassium (PcG) and cephalothin sodium (CET), in guinea-pig strains [19].
• Cefamandole nafate and cephalothin sodium were administered as prophylaxis in a randomized, prospective study to 80 consecutive patients undergoing open heart surgery [20].

Analytical, diagnostic and therapeutic context of Cefalotin

• Antibodies to cephalothin sodium (Keflin) can be transferred passively via whole blood transfusion [21].
• Of the nine antibiotics, cephalothin sodium had the lowest (and therefore the best) minimum bactericidal concentration (MBC) and minimum inhibitory concentration (MIC) [22].
• Amorphous, partially crystalline, and crystalline forms were prepared and characterized by X-ray diffraction (powder), by solution calorimetry, and, for cephalothin sodium, by the thermal decomposition rate at 50 degrees [23].
• The dog improved after treatment with cephalothin sodium, iv fluid therapy, and cage rest [24].
• The mechanism of granularly agglomerated crystallization during freezing of cephalothin sodium (CET-Na) in aqueous solution has been discussed [25].

References