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MeSH Review

Femoral Fractures

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Disease relevance of Femoral Fractures

  • The value of low dosage heparin for the prophylaxis of thromboembolism in patients with transcervical and intertrochanteric femoral fractures [1].
  • In rats subjected to moderately severe injury (dorsal wounding or unilateral femoral fracture), supplemental vitamin A greatly diminished the thymic involution observed in chow-fed controls and delayed or minimized the accompanying adrenal hypertrophy [2].
  • The rate of technical failure in patients with unstable trochanteric fractures was 6.5% (6/93) (including intra-operative femoral fractures) in the SGN group and 5.2% (5/96) in the MSP group [3].
  • The healing of femoral fractures in an experimental rat pseudoarthrosis model was followed by studying the expression of cartilage specific genes coding for type II and X collagens and aggrecan, soft tissue and bone specific type I collagen, and decorin [4].
  • Mechanical properties of healing femoral fractures, intact femora, healing skin wounds and intact skin, have been studied in young male rats during treatment with salmon calcitonin (CT) (3 MCR-U/kg body weight/day) [5].

Psychiatry related information on Femoral Fractures


High impact information on Femoral Fractures


Chemical compound and disease context of Femoral Fractures


Biological context of Femoral Fractures


Anatomical context of Femoral Fractures


Gene context of Femoral Fractures

  • Deletion of the iNOS gene decreased the total and maximum energy absorption of the healing femoral fracture by 30% and by 70% (P<0.01), respectively, in comparison to the wild-type mice [21].
  • Using a rat model of closed femoral fracture healing, we analyzed the spatial and temporal expression of FGFR3 [22].
  • The sfx/sfx mouse is characterized by a spontaneous femoral fracture seen around 6 weeks of age, which represents a new mouse model for bone fragility [23].
  • These findings indicate that BMP-4 and rDlx are selectively expressed following femoral fracture in the rat, and also suggest that they are involved in the formation of the callus at an early point during the postfracture healing of bone [24].
  • MRSA in patients presenting with femoral fractures [25].

Analytical, diagnostic and therapeutic context of Femoral Fractures


  1. The value of low dosage heparin for the prophylaxis of thromboembolism in patients with transcervical and intertrochanteric femoral fractures. Galasko, C.S., Edwards, D.H., Fearn, C.B., Barber, H.M. Acta orthopaedica Scandinavica. (1976) [Pubmed]
  2. White cell involvement in the inflammatory, wound healing, and immune actions of vitamin A. Barbul, A., Thysen, B., Rettura, G., Levenson, S.M., Seifter, E. JPEN. Journal of parenteral and enteral nutrition. (1978) [Pubmed]
  3. The standard Gamma nail or the Medoff sliding plate for unstable trochanteric and subtrochanteric fractures. A randomised, controlled trial. Miedel, R., Ponzer, S., Törnkvist, H., Söderqvist, A., Tidermark, J. The Journal of bone and joint surgery. British volume. (2005) [Pubmed]
  4. Extended expression of cartilage components in experimental pseudoarthrosis. Ekholm, E.C., Hietaniemi, K., Määttä, A., Vuorio, E., Paavolainen, P., Penttinen, R.P. Connect. Tissue Res. (1995) [Pubmed]
  5. Effects of salmon calcitonin on mechanical properties of healing and intact bone and skin in rats. Ekeland, A., Myhre, L., Underdal, T. Acta orthopaedica Scandinavica. (1983) [Pubmed]
  6. Osteomalacia and osteoporosis in femoral neck fracture. Hordon, L.D., Peacock, M. Bone and mineral. (1990) [Pubmed]
  7. Letter: Ozone, parathyroiditis, and femoral fractures. Atwal, O.S. Lancet (1975) [Pubmed]
  8. Nitric oxide modulates fracture healing. Diwan, A.D., Wang, M.X., Jang, D., Zhu, W., Murrell, G.A. J. Bone Miner. Res. (2000) [Pubmed]
  9. Enhanced expression of type I receptors for bone morphogenetic proteins during bone formation. Ishidou, Y., Kitajima, I., Obama, H., Maruyama, I., Murata, F., Imamura, T., Yamada, N., ten Dijke, P., Miyazono, K., Sakou, T. J. Bone Miner. Res. (1995) [Pubmed]
  10. Spontaneous hip fractures in fluoride-treated patients: potential causative factors. Gutteridge, D.H., Price, R.I., Kent, G.N., Prince, R.L., Michell, P.A. J. Bone Miner. Res. (1990) [Pubmed]
  11. Influence of vitamin A on wound healing in rats with femoral fracture. Seifter, E., Crowley, L.V., Rettura, G., Nakao, K., Gruber, C., Kan, D., Levenson, S.M. Ann. Surg. (1975) [Pubmed]
  12. Serum 1alpha,25-dihydroxyvitamin D3 accumulates into the fracture callus during rat femoral fracture healing. Jingushi, S., Iwaki, A., Higuchi, O., Azuma, Y., Ohta, T., Shida, J.I., Izumi, T., Ikenoue, T., Sugioka, Y., Iwamoto, Y. Endocrinology (1998) [Pubmed]
  13. The effect of 25-dihydroxyvitamin D on the bone mineral metabolism of elderly women with hip fracture. Sosa, M., Láinez, P., Arbelo, A., Navarro, M.C. Rheumatology (Oxford, England) (2000) [Pubmed]
  14. Urinary excretion of pyridinium crosslinks of collagen in patients with osteoporosis and the effects of bone fracture. McLaren, A.M., Hordon, L.D., Bird, H.A., Robins, S.P. Ann. Rheum. Dis. (1992) [Pubmed]
  15. Effect of dietary copper, manganese, and zinc on nitrogen equilibrium and mineral distribution subsequent to trauma in mature rats. Thompson, H.J., Griminger, P., Evans, J.L. J. Nutr. (1976) [Pubmed]
  16. Comparison of titanium elastic nails with traction and a spica cast to treat femoral fractures in children. Flynn, J.M., Luedtke, L.M., Ganley, T.J., Dawson, J., Davidson, R.S., Dormans, J.P., Ecker, M.L., Gregg, J.R., Horn, B.D., Drummond, D.S. The Journal of bone and joint surgery. American volume. (2004) [Pubmed]
  17. The influence of dichloromethylene bisphosphonate on the healing of a long bone fracture, composition of bone mineral and histology of bone in the rat. Hyvönen, P.M., Karhi, T., Kosma, V.M., Liimola-Luoma, L., Hanhijärvi, H. Pharmacol. Toxicol. (1994) [Pubmed]
  18. Treatment of closed femoral diaphyseal fractures with external fixators in children. Kapukaya, A., Subaşi, M., Necmioğlu, S., Arslan, H., Kesemenli, C., Yildirim, K. Archives of orthopaedic and trauma surgery. (1998) [Pubmed]
  19. Combined lumbar and sacral plexus block compared with plain bupivacaine spinal anesthesia for hip fractures in the elderly. de Visme, V., Picart, F., Le Jouan, R., Legrand, A., Savry, C., Morin, V. Regional anesthesia and pain medicine. (2000) [Pubmed]
  20. Metabolic and immune effects of arginine in postinjury hyperalimentation. Barbul, A., Sisto, D.A., Wasserkrug, H.L., Yoshimura, N.N., Efron, G. The Journal of trauma. (1981) [Pubmed]
  21. Deletion of iNOS gene impairs mouse fracture healing. Baldik, Y., Diwan, A.D., Appleyard, R.C., Fang, Z.M., Wang, Y., Murrell, G.A. Bone (2005) [Pubmed]
  22. Expression of fibroblast growth factor receptor-3 (FGFR3), signal transducer and activator of transcription-1, and cyclin-dependent kinase inhibitor p21 during endochondral ossification: differential role of FGFR3 in skeletal development and fracture repair. Nakajima, A., Shimizu, S., Moriya, H., Yamazaki, M. Endocrinology (2003) [Pubmed]
  23. A deletion causing spontaneous fracture identified from a candidate region of mouse Chromosome 14. Jiao, Y., Li, X., Beamer, W.G., Yan, J., Tong, Y., Goldowitz, D., Roe, B., Gu, W. Mamm. Genome (2005) [Pubmed]
  24. Expression of bone morphogenetic proteins and rat distal-less homolog genes following rat femoral fracture. Yaoita, H., Orimo, H., Shirai, Y., Shimada, T. J. Bone Miner. Metab. (2000) [Pubmed]
  25. MRSA in patients presenting with femoral fractures. Levy, B.F., Rosson, J.W., Blake, A. The surgeon : journal of the Royal Colleges of Surgeons of Edinburgh and Ireland. (2004) [Pubmed]
  26. Biochemical changes after trauma and skeletal surgery of the lower extremity: quantification of the operative burden. Pape, H.C., Schmidt, R.E., Rice, J., van Griensven, M., das Gupta, R., Krettek, C., Tscherne, H. Crit. Care Med. (2000) [Pubmed]
  27. Femoral fractures in postmenopausal breast cancer patients treated with adjuvant tamoxifen. Kristensen, B., Ejlertsen, B., Mouridsen, H.T., Andersen, K.W., Lauritzen, J.B. Breast Cancer Res. Treat. (1996) [Pubmed]
  28. Supracondylar femoral fracture above a PFC posterior cruciate-substituting total knee arthroplasty treated with supracondylar nailing. A unique technical problem. Maniar, R.N., Umlas, M.E., Rodriguez, J.A., Ranawat, C.S. The Journal of arthroplasty. (1996) [Pubmed]
  29. Metastatic hepatocellular carcinoma to bone in a liver transplant patient. A case report. Kay, R.M., Eckardt, J.J., Goldstein, L.I., Busuttil, R.W. Clin. Orthop. Relat. Res. (1994) [Pubmed]
  30. Bone resorption and "relative" immobilization hypercalcemia with prolonged continuous renal replacement therapy and citrate anticoagulation. Wang, P.L., Meyer, M.M., Orloff, S.L., Anderson, S. Am. J. Kidney Dis. (2004) [Pubmed]
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