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Gene Review

MUC7  -  mucin 7, secreted

Homo sapiens

Synonyms: Apo-MG2, FLJ27047, MG2, MUC-7, Mucin-7, ...
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Disease relevance of MUC7


High impact information on MUC7


Biological context of MUC7


Anatomical context of MUC7


Associations of MUC7 with chemical compounds

  • Upon LPS stimulation, the overexpressed MUC7 remains confined to the serous glands [7].
  • By immunohistochemistry, MUC7 glycoprotein was localized in tracheal submucosa within the serous cells [7].
  • In vitro synergic antifungal effect of MUC7 12-mer with histatin-5 12-mer or miconazole [14].
  • Antifungal activities of MUC7 12-mer in combination with other compounds [histatin-5 (Hsn5) 12-mer: AKRHHGYKRKFH, amphotericin B or miconazole] against C. albicans and C. neoformans were determined by chequerboard assays and confirmed by killing assays [14].
  • Two monoclonal antibodies, directed against gp-340, were characterized. mAb 213-1 reacted with sialic acid epitopes and cross-reacted with MUC7 [15].

Other interactions of MUC7

  • In the submucosal glands, MUC2 mRNAs are located in both mucous and serous cells, whereas MUC5B and MUC7 mRNAs are expressed in mucous and in serous cells, respectively [8].
  • MUC6 was positive in 13/40 tumors, and both MUC2 and MUC7 in only 2/40 tumors [16].
  • Although a complete protein sequence is known for only three human mucins (MUC1, MUC2, and MUC7), common motifs have been identified in many mucins [17].
  • MUC7 12-mer (residues 40-51 of the parent MUC7) peptide, having the optimal size and a net charge of +6, was found to be anticandidal in human saliva (clarified and unclarified), and its candidacidal potency was found to be superior to that of histatin 5 12-mer (Hsn5 12-mer) [3].
  • This active coping response was associated with an enhanced secretion ( microg/min, controlling for salivary flow rate) of MUC7, lactoferrin, alpha-amylase, and total salivary protein [18].

Analytical, diagnostic and therapeutic context of MUC7


  1. Altered sialyl- and fucosyl-linkage on mucins in cystic fibrosis patients promotes formation of the sialyl-Lewis X determinant on salivary MUC-5B and MUC-7. Shori, D.K., Genter, T., Hansen, J., Koch, C., Wyatt, H., Kariyawasam, H.H., Knight, R.A., Hodson, M.E., Kalogeridis, A., Tsanakas, I. Pflugers Arch. (2001) [Pubmed]
  2. Detection of bone marrow-disseminated breast cancer cells using an RT-PCR assay of MUC5B mRNA. Berois, N., Varangot, M., Sóñora, C., Zarantonelli, L., Pressa, C., Laviña, R., Rodríguez, J.L., Delgado, F., Porchet, N., Aubert, J.P., Osinaga, E. Int. J. Cancer (2003) [Pubmed]
  3. Antifungal activity of human salivary mucin-derived peptide, MUC7 12-mer, in a murine model of oral candidiasis. Muralidharan, R., Bobek, L.A. J. Pept. Res. (2005) [Pubmed]
  4. The role of crude human saliva and purified salivary MUC5B and MUC7 mucins in the inhibition of Human Immunodeficiency Virus type 1 in an inhibition assay. Habte, H.H., Mall, A.S., de Beer, C., Lotz, Z.E., Kahn, D. Virol. J. (2006) [Pubmed]
  5. Developmental expression of mucin genes in the human gastrointestinal system. Reid, C.J., Harris, A. Gut (1998) [Pubmed]
  6. Functional Analysis of Human MUC7 Mucin Gene 5'-Flanking Region in Lung Epithelial Cells. Li, S., Bobek, L.A. Am. J. Respir. Cell Mol. Biol. (2006) [Pubmed]
  7. Modulation of MUC7 mucin expression by exogenous factors in airway cells in vitro and in vivo. Li, S., Intini, G., Bobek, L.A. Am. J. Respir. Cell Mol. Biol. (2006) [Pubmed]
  8. Developmental mucin gene expression in the human respiratory tract. Buisine, M.P., Devisme, L., Copin, M.C., Durand-Réville, M., Gosselin, B., Aubert, J.P., Porchet, N. Am. J. Respir. Cell Mol. Biol. (1999) [Pubmed]
  9. Mucin gene expression in human urothelium and in intestinal segments transposed into the urinary tract. N'Dow, J., Pearson, J.P., Bennett, M.K., Neal, D.E., Robson, C.N. J. Urol. (2000) [Pubmed]
  10. MUC7 gene expression and genetic polymorphism. Biesbrock, A.R., Bobek, L.A., Levine, M.J. Glycoconj. J. (1997) [Pubmed]
  11. Characterization of mucins in human lacrimal sac and nasolacrimal duct. Paulsen, F.P., Corfield, A.P., Hinz, M., Hoffmann, W., Schaudig, U., Thale, A.B., Berry, M. Invest. Ophthalmol. Vis. Sci. (2003) [Pubmed]
  12. Expression of secretory mucin genes by human conjunctival epithelia. Inatomi, T., Spurr-Michaud, S., Tisdale, A.S., Zhan, Q., Feldman, S.T., Gipson, I.K. Invest. Ophthalmol. Vis. Sci. (1996) [Pubmed]
  13. Identification of a major human high molecular weight salivary mucin (MG1) as tracheobronchial mucin MUC5B. Nielsen, P.A., Bennett, E.P., Wandall, H.H., Therkildsen, M.H., Hannibal, J., Clausen, H. Glycobiology (1997) [Pubmed]
  14. In vitro synergic antifungal effect of MUC7 12-mer with histatin-5 12-mer or miconazole. Wei, G.X., Bobek, L.A. J. Antimicrob. Chemother. (2004) [Pubmed]
  15. Immunohistochemical detection of salivary agglutinin/gp-340 in human parotid, submandibular, and labial salivary glands. Bikker, F.J., Ligtenberg, A.J., van der Wal, J.E., van den Keijbus, P.A., Holmskov, U., Veerman, E.C., Nieuw Amerongen, A.V. J. Dent. Res. (2002) [Pubmed]
  16. Expression of membrane-bound mucins (MUC1 and MUC4) and secreted mucins (MUC2, MUC5AC, MUC5B, MUC6 and MUC7) in mucoepidermoid carcinomas of salivary glands. Alos, L., Lujan, B., Castillo, M., Nadal, A., Carreras, M., Caballero, M., de Bolos, C., Cardesa, A. Am. J. Surg. Pathol. (2005) [Pubmed]
  17. Mucin glycoproteins in neoplasia. Kim, Y.S., Gum, J., Brockhausen, I. Glycoconj. J. (1996) [Pubmed]
  18. Innate secretory immunity in response to laboratory stressors that evoke distinct patterns of cardiac autonomic activity. Bosch, J.A., de Geus, E.J., Veerman, E.C., Hoogstraten, J., Nieuw Amerongen, A.V. Psychosomatic medicine. (2003) [Pubmed]
  19. Human mucin genes MUC2, MUC3, MUC4, MUC5AC, MUC5B, and MUC6 express stable and extremely large mRNAs and exhibit a variable length polymorphism. An improved method to analyze large mRNAs. Debailleul, V., Laine, A., Huet, G., Mathon, P., d'Hooghe, M.C., Aubert, J.P., Porchet, N. J. Biol. Chem. (1998) [Pubmed]
  20. MUC7 expression in the human lacrimal gland and conjunctiva. Jumblatt, M.M., McKenzie, R.W., Steele, P.S., Emberts, C.G., Jumblatt, J.E. Cornea (2003) [Pubmed]
  21. Human carcinoma-associated and salivary mucins detected by anti-bovine submaxillary mucin antibodies. Golubović, S.J., Bojić-Trbojević, Z.T. Biochemistry Mosc. (2006) [Pubmed]
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