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Chemical Compound Review

Cycleane     (8S,9S,10R,13S,14S,17S)-13- ethyl-17...

Synonyms: Desolett, Securgin, Caziant, Emoquette, Gracial, ...
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Disease relevance of Marvelon


High impact information on Marvelon

  • Haplotypic variation was largely species-independent, although some very weak associations were detected between haplotypes H1 and H4 and morphological and nuclear molecular variation correspondingly characterizing Q. affinis and Q. laurina [4].
  • Furthermore, women taking Cileste had lower levels of natural killer (NK) cells during their cycle and also women taking Marvelon but only from days 8-15 [5].
  • These markers revealed genetic diversity within the populations of these plants from Nilgiri and also between two populations of S. laurina from Nilgiri and Amboli [6].
  • Two populations of S. laurina, separated by > 1000 km, showed a high within-population variation (53.7%) and a low gene flow (Nm = 0.447). upgma phenograms depicted a tendency of accessions to group according to their geographical locations in all the three plant species [6].
  • Implanon significantly increased glandular PR staining, but Mircette significantly reduced stromal PR staining when compared to secretory phase before-treatment biopsies [7].

Biological context of Marvelon


Anatomical context of Marvelon


Associations of Marvelon with other chemical compounds


Gene context of Marvelon

  • Lovelle increased CD19 and CD23 after 21 days' treatment [12].
  • Implanon significantly increased (P = 0.016) glandular PR staining, but Mircette significantly reduced (P = 0.027) stromal PR staining when compared with secretory before-treatment biopsies [16].
  • In this open-label, randomized study we compared the influence of a new oral contraceptive containing 30 microg ethinylestradiol and 3 mg drospirenone (EE + DRSP = Yasmin), with a reference preparation containing 30 microg ethinylestradiol and 150 microg desogestrel (EE + DSG = Marvelon) on the lipid profile [17].

Analytical, diagnostic and therapeutic context of Marvelon


  1. Treatment of hirsutism with flutamide and a low-dosage oral contraceptive in polycystic ovarian disease patients. Ciotta, L., Cianci, A., Marletta, E., Pisana, L., Aglianò, A., Palumbo, G. Fertil. Steril. (1994) [Pubmed]
  2. Efficacy, cycle control, and safety of two triphasic oral contraceptives: Cyclessa (desogestrel/ethinyl estradiol) and ortho-Novum 7/7/7 (norethindrone/ethinyl estradiol): a randomized clinical trial. Kaunitz, A.M. Contraception. (2000) [Pubmed]
  3. Fatal pulmonary embolus in a patient treated with Marvelon. Scolding, N.J., Gibby, O.M. The Journal of the Royal College of General Practitioners. (1988) [Pubmed]
  4. Chloroplast DNA variation in the Quercus affinis-Q. laurina complex in Mexico: geographical structure and associations with nuclear and morphological variation. González-Rodríguez, A., Bain, J.F., Golden, J.L., Oyama, K. Mol. Ecol. (2004) [Pubmed]
  5. Influence of low-dose oral contraception on peripheral blood lymphocyte subsets at particular phases of the hormonal cycle. Auerbach, L., Hafner, T., Huber, J.C., Panzer, S. Fertil. Steril. (2002) [Pubmed]
  6. Genetic diversity across natural populations of three montane plant species from the Western Ghats, India revealed by intersimple sequence repeats. Deshpande, A.U., Apte, G.S., Bahulikar, R.A., Lagu, M.D., Kulkarni, B.G., Suresh, H.S., Singh, N.P., Rao, M.K., Gupta, V.S., Pant, A., Ranjekar, P.K. Mol. Ecol. (2001) [Pubmed]
  7. The effect of progestins on vascular endothelial growth factor, oestrogen receptor and progesterone receptor immunoreactivity and endothelial cell density in human endometrium. Charnock-Jones, D.S., Macpherson, A.M., Archer, D.F., Leslie, S., Makkink, W.K., Sharkey, A.M., Smith, S.K. Hum. Reprod. (2000) [Pubmed]
  8. Metabolic and endocrine effects of the desogestrel-containing oral contraceptive Mircette. Berga, S.L. Am. J. Obstet. Gynecol. (1998) [Pubmed]
  9. Effects of ethinyl estradiol combined with desogestrel and cyproterone acetate on glucose tolerance and insulin response to an oral glucose load: a one-year randomized, prospective, comparative trial. Jandrain, B.J., Humblet, D.M., Jaminet, C.B., Scheen, A.J., Gaspard, U.J., Lefebvre, P.J. Am. J. Obstet. Gynecol. (1990) [Pubmed]
  10. Multicenter study in Hungary with a 30 micrograms ethinylestradiol- and 150 micrograms desogestrel-containing monophasic oral contraceptive. Bruyniks, N., Kovacs, L., Rákóczi, I. Advances in contraception : the official journal of the Society for the Advancement of Contraception. (1994) [Pubmed]
  11. Evaluation of a combined oral contraceptive pill in black Zimbabwean women. Kasule, J., Mbizvo, M., Makuyana, D., Masona, D. The Central African journal of medicine. (1991) [Pubmed]
  12. A comparative study of the effects of two oral contraceptives containing dienogest or desogestrel on the human immune system. Klinger, G., Gräser, T., Mellinger, U., Moore, C., Vogelsang, H., Groh, A., Latterman, C., Klinger, G. Gynecol. Endocrinol. (2000) [Pubmed]
  13. Ovarian activity in women taking an oral contraceptive containing 20 microg ethinyl estradiol and 150 microg desogestrel: effects of low estrogen doses during the hormone-free interval. Killick, S.R., Fitzgerald, C., Davis, A. Am. J. Obstet. Gynecol. (1998) [Pubmed]
  14. A cross-over study of three oral contraceptives containing ethinyloestradiol and either desogestrel or levonorgestrel. Song, S., Chen, J.K., Yang, P.J., He, M.L., Li, L.M., Fan, B.C., Rekers, H., Fotherby, K. Contraception. (1992) [Pubmed]
  15. Comparative metabolic effects of three types of combined oral contraceptive pills in Chinese women. Prasad, R.N., Liew, D., Ratnam, S.S. Contraception. (1989) [Pubmed]
  16. The effect of etonogestrel on VEGF, oestrogen and progesterone receptor immunoreactivity and endothelial cell number in human endometrium. Macpherson, A.M., Archer, D.F., Leslie, S., Charnock-Jones, D.S., Makkink, W.K., Smith, S.K. Hum. Reprod. (1999) [Pubmed]
  17. A randomized study on the influence of oral contraceptives containing ethinylestradiol combined with drospirenone or desogestrel on lipid and lipoprotein metabolism over a period of 13 cycles. Gaspard, U., Endrikat, J., Desager, J.P., Buicu, C., Gerlinger, C., Heithecker, R. Contraception. (2004) [Pubmed]
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