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Chemical Compound Review

CID6328047     dipotassium; antimony; 2,3...

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Disease relevance of tartaric acid


High impact information on tartaric acid


Chemical compound and disease context of tartaric acid

  • Deoxyribonucleic acid (DNA) synthesis by cell of E. coli B from either the maximum stationary phase or the exponential phase are inhibited by 3.62 mM of bilharcid or 16.81 mM of tartar-emetic immediately upon addition of the inhibitor [11].
  • Tartar emetic (potassium antimony tartrate) has been used since a long time as the drug of choice for the treatment of Bilharziasis in Egypt. This drug, though effective, has severe side effects [12].

Biological context of tartaric acid


Anatomical context of tartaric acid


Associations of tartaric acid with other chemical compounds


Gene context of tartaric acid


Analytical, diagnostic and therapeutic context of tartaric acid


  1. Antimony-based antileishmanial compounds prolong the cardiac action potential by an increase in cardiac calcium currents. Kuryshev, Y.A., Wang, L., Wible, B.A., Wan, X., Ficker, E. Mol. Pharmacol. (2006) [Pubmed]
  2. Anthelmintics. Katz, M. Drugs (1977) [Pubmed]
  3. Overexpression of the multidrug resistance-associated protein (MRP1) in human heavy metal-selected tumor cells. Vernhet, L., Courtois, A., Allain, N., Payen, L., Anger, J.P., Guillouzo, A., Fardel, O. FEBS Lett. (1999) [Pubmed]
  4. Formation of methylantimony species by an aerobic prokaryote: Flavobacterium sp. Jenkins, R.O., Forster, S.N., Craig, P.J. Arch. Microbiol. (2002) [Pubmed]
  5. Effects of antimony on rats following 90-day exposure via drinking water. Poon, R., Chu, I., Lecavalier, P., Valli, V.E., Foster, W., Gupta, S., Thomas, B. Food Chem. Toxicol. (1998) [Pubmed]
  6. Cross-resistance between cisplatin, antimony potassium tartrate, and arsenite in human tumor cells. Naredi, P., Heath, D.D., Enns, R.E., Howell, S.B. J. Clin. Invest. (1995) [Pubmed]
  7. The glycerol channel Fps1p mediates the uptake of arsenite and antimonite in Saccharomyces cerevisiae. Wysocki, R., Chéry, C.C., Wawrzycka, D., Van Hulle, M., Cornelis, R., Thevelein, J.M., Tamás, M.J. Mol. Microbiol. (2001) [Pubmed]
  8. Altered expression of the MYCN oncogene modulates MRP gene expression and response to cytotoxic drugs in neuroblastoma cells. Haber, M., Bordow, S.B., Gilbert, J., Madafiglio, J., Kavallaris, M., Marshall, G.M., Mechetner, E.B., Fruehauf, J.P., Tee, L., Cohn, S.L., Salwen, H., Schmidt, M.L., Norris, M.D. Oncogene (1999) [Pubmed]
  9. In vitro antileishmanial properties of tri- and pentavalent antimonial preparations. Roberts, W.L., Berman, J.D., Rainey, P.M. Antimicrob. Agents Chemother. (1995) [Pubmed]
  10. The heat shock protein HSP70 and heat shock cognate protein HSC70 contribute to antimony tolerance in the protozoan parasite leishmania. Brochu, C., Haimeur, A., Ouellette, M. Cell Stress Chaperones (2004) [Pubmed]
  11. Mechanism of action of bilharcid and tartar-emetic. Khafagy, E.Z., El-Hawary, M.F. Zentralblatt für Bakteriologie, Parasitenkunde, Infektionskrankheiten und Hygiene. Zweite naturwissenschaftliche Abteilung: Mikrobiologie der Landwirtschaft der Technologie und des Umweltschutzes. (1978) [Pubmed]
  12. Preliminary report on some clinical and biochemical observations in patients treated with Bilharcid. Faríd, F., Moussà, A.H., Abulfadl, A.M., El-Raziky, E.H., Adham, I. Egyptian journal of bilharziasis. (1975) [Pubmed]
  13. Potassium antimonyl tartrate induces caspase- and reactive oxygen species-dependent apoptosis in lymphoid tumoral cells. Lecureur, V., Le Thiec, A., Le Meur, A., Amiot, L., Drenou, B., Bernard, M., Lamy, T., Fauchet, R., Fardel, O. Br. J. Haematol. (2002) [Pubmed]
  14. The role of intracellular calcium in antimony-induced toxicity in cultured cardiac myocytes. Wey, H.E., Richards, D., Tirmenstein, M.A., Mathias, P.I., Toraason, M. Toxicol. Appl. Pharmacol. (1997) [Pubmed]
  15. Experimental studies on the evolution of antimony-resistant phenotype during the in vitro life cycle of Leishmania infantum: implications for the spread of chemoresistance in endemic areas. Sereno, D., Guilvard, E., Maquaire, S., Cavaleyra, M., Holzmuller, P., Ouaissi, A., Lemesre, J.L. Acta Trop. (2001) [Pubmed]
  16. Effects of trivalent antimony on human erythrocyte glutathione-S-transferases. Poon, R., Chu, I. J. Biochem. Mol. Toxicol. (2000) [Pubmed]
  17. Structural requirements for chelate antidotal efficacy in acute antimony(III) intoxication. Basinger, M.A., Jones, M.M. Res. Commun. Chem. Pathol. Pharmacol. (1981) [Pubmed]
  18. Antimony-induced oxidative stress and toxicity in cultured cardiac myocytes. Tirmenstein, M.A., Plews, P.I., Walker, C.V., Woolery, M.D., Wey, H.E., Toraason, M.A. Toxicol. Appl. Pharmacol. (1995) [Pubmed]
  19. Purification, kinetics and inhibition by antimonials of recombinant phosphofructokinase from Schistosoma mansoni. Su, J.G., Mansour, J.M., Mansour, T.E. Mol. Biochem. Parasitol. (1996) [Pubmed]
  20. Potassium antimonyl tartrate induces reactive oxygen species-related apoptosis in human myeloid leukemic HL60 cells. Lecureur, V., Lagadic-Gossmann, D., Fardel, O. Int. J. Oncol. (2002) [Pubmed]
  21. The immune-dependence of schistosomicidal chemotherapy: relative lack of efficacy of an antimonial in Schistosoma mansoni-infected mice deprived of their T-cells and the demonstration of drug-antiserum synergy. Doenhoff, M.J., Bain, J. Clin. Exp. Immunol. (1978) [Pubmed]
  22. Effects of potassium antimony tartrate on rat erythrocyte phosphofructokinase activity. Poon, R., Chu, I. J. Biochem. Mol. Toxicol. (1998) [Pubmed]
  23. Antimony quantification in Leishmania by electrothermal atomic absorption spectroscopy. Roberts, W.L., Rainey, P.M. Anal. Biochem. (1993) [Pubmed]
  24. Amplification of the ABC transporter gene PGPA and increased trypanothione levels in potassium antimonyl tartrate (SbIII) resistant Leishmania tarentolae. Haimeur, A., Brochu, C., Genest, P., Papadopoulou, B., Ouellette, M. Mol. Biochem. Parasitol. (2000) [Pubmed]
  25. Studies on the association of 2-thiazolidinecarboxylic acid and antimony potassium tartrate: chiral recognition and prediction of absolute configuration by electrospray ionization mass spectrometry. Arakawa, R., Kobayashi, M., Fukuo, T., Shiraiwa, T. Rapid Commun. Mass Spectrom. (2001) [Pubmed]
  26. Reversal of MRP-mediated multidrug resistance in human lung cancer cells by the antiprogestatin drug RU486. Payen, L., Delugin, L., Courtois, A., Trinquart, Y., Guillouzo, A., Fardel, O. Biochem. Biophys. Res. Commun. (1999) [Pubmed]
  27. The immunological aspects of praziquantel in unsensitized mice with experimentally induced schistosome pulmonary granuloma. Botros, S.S., Metwally, A.A., Khayyal, M.T. Trans. R. Soc. Trop. Med. Hyg. (1984) [Pubmed]
  28. Laboratory and clinical stain removal evaluations of two tartar control dentifrices. Yankell, S.L., Emling, R.C., Prencipe, M., Rustogi, K., Volpe, A.R. The Journal of clinical dentistry. (1995) [Pubmed]
  29. Interspecific variation in the emetic response of anurans. Naitoh, T., Imamura, M., Wassersug, R.J. Comp. Biochem. Physiol. C, Comp. Pharmacol. Toxicol. (1991) [Pubmed]
  30. Comparative toxicity and tissue distribution of antimony potassium tartrate in rats and mice dosed by drinking water or intraperitoneal injection. Dieter, M.P., Jameson, C.W., Elwell, M.R., Lodge, J.W., Hejtmancik, M., Grumbein, S.L., Ryan, M., Peters, A.C. Journal of toxicology and environmental health. (1991) [Pubmed]
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