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Chemical Compound Review

Dioform     (E)-1,2-dichloroethene

Synonyms: AC1LCVUR, CHEMBL157026, HSDB 149, CCRIS 2505, CCRIS 6227, ...
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Disease relevance of sym-Dichloroethylene


Psychiatry related information on sym-Dichloroethylene


High impact information on sym-Dichloroethylene


Biological context of sym-Dichloroethylene


Anatomical context of sym-Dichloroethylene

  • Hepatocytes isolated from partially hepatectomized animals were resistant to the cytotoxicity of AFB1 and chloroform but not to the cytotoxicity of 1,2-DBE or 1,2-DCE [15].

Associations of sym-Dichloroethylene with other chemical compounds


Gene context of sym-Dichloroethylene

  • The combination treatment caused testicular atrophy and histopathology in the liver and testes at 1,2-DCE inhalation concentrations greater than 300 ppm (an estimated dose of 194 mg/kg body wt/day) administered 5 days/week for 30 days or at ip doses of 150 mg 1,2-DCE/kg body wt/day over 30 days, 7 days/week [4].
  • NTP Technical Report on the toxicity studies of trans-1,2-dichloroethylene (CAS no. 156-60-5) administered in microcapsules in feed to F344/N rats and B6C3F(1) mice [14].

Analytical, diagnostic and therapeutic context of sym-Dichloroethylene

  • The present study examines the effect on liver tumor incidence of continuous treatment of CHCl3 (600 mg/L and 1800 mg/L), 1,1-DCE (835 mg/L and 2500 mg/L), and 1,2-DCE (835 mg/L and 2500 mg/L) administered in drinking water to male B6C3F1 mice using a two-stage (initiation/promotion) treatment protocol [18].
  • Quantitative real-time polymerase chain reaction (PCR) with a fluorescently labelled linear hybridization probe confirmed growth with these electron acceptors, and suggested that strain FL2 captures energy from both the TCE-to-cis-DCE and 1,2-DCE-to-VC dechlorination steps [19].
  • There was no micronucleus induction or PCE suppression detected in the blood of either sex after treatment with 1 and 3 mg/kg DEN or 100 to 300 mg/kg 1,2-DCE [10].
  • Analysis of halogenated hydrocarbons in trans-1,2-dichloroethylene by thick-film, wide-bore, capillary gas chromatography [20].
  • In vivo, no induction of SCEs or Abs was noted in bone marrow cells of male mice administered cis- or trans-1,2-dichloroethylene by intraperitoneal injection once, with sampling performed 23 hours (for SCE analyses) or 17 hours (for Abs analyses) after injection [14].


  1. Directed evolution of toluene ortho-monooxygenase for enhanced 1-naphthol synthesis and chlorinated ethene degradation. Canada, K.A., Iwashita, S., Shim, H., Wood, T.K. J. Bacteriol. (2002) [Pubmed]
  2. Mixed Pollutant Degradation by Methylosinus trichosporium OB3b Expressing either Soluble or Particulate Methane Monooxygenase: Can the Tortoise Beat the Hare? Lee, S.W., Keeney, D.R., Lim, D.H., Dispirito, A.A., Semrau, J.D. Appl. Environ. Microbiol. (2006) [Pubmed]
  3. Toxicity studies on trans-1,2-dichloroethylene. Freundt, K.J., Liebaldt, G.P., Lieberwirth, E. Toxicology (1977) [Pubmed]
  4. Interaction between 1,2-dichloroethane and disulfiram. I. Toxicologic effects. Igwe, O.J., Que Hee, S.S., Wagner, W.D. Fundamental and applied toxicology : official journal of the Society of Toxicology. (1986) [Pubmed]
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  7. Selective inhibition of cytochrome P450 2E1 in vivo and in vitro with trans-1,2-dichloroethylene. Mathews, J.M., Etheridge, A.S., Raymer, J.H., Black, S.R., Pulliam, D.W., Bucher, J.R. Chem. Res. Toxicol. (1998) [Pubmed]
  8. Hepatic microsomal metabolism of the dichloroethanes. McCall, S.N., Jurgens, P., Ivanetich, K.M. Biochem. Pharmacol. (1983) [Pubmed]
  9. Inhibition of cytochrome P450 2E1 decreases, but does not eliminate, genotoxicity mediated by 1,3-butadiene. Jackson, T.E., Lilly, P.D., Recio, L., Schlosser, P.M., Medinsky, M.A. Toxicol. Sci. (2000) [Pubmed]
  10. Micronuclei induced in peripheral blood of E mu-PIM-1 transgenic mice by chronic oral treatment with 2-acetylaminofluorene or benzene but not with diethyl-nitrosamine or 1,2-dichloroethane. Armstrong, M.J., Galloway, S.M. Mutat. Res. (1993) [Pubmed]
  11. Genetic effects of chlorinated ethylenes in the yeast Saccharomyces cerevisiae. Koch, R., Schlegelmilch, R., Wolf, H.U. Mutat. Res. (1988) [Pubmed]
  12. Toxicology of trans-1,2-dichloroethylene in the mouse. Barnes, D.W., Sanders, V.M., White, K.L., Shopp, G.M., Munson, A.E. Drug and chemical toxicology. (1985) [Pubmed]
  13. Humoral and cell-mediated immune status of mice exposed to trans-1,2-dichloroethylene. Shopp, G.M., Sanders, V.M., White, K.L., Munson, A.E. Drug and chemical toxicology. (1985) [Pubmed]
  14. NTP Technical Report on the toxicity studies of trans-1,2-dichloroethylene (CAS no. 156-60-5) administered in microcapsules in feed to F344/N rats and B6C3F(1) mice. Ress, N.B. Toxicity report series. (2002) [Pubmed]
  15. Cytotoxicity of halogenated alkanes in primary cultures of rat hepatocytes from normal, partial hepatectomized, and preneoplastic/neoplastic liver. Chang, L.W., Pereira, M.A., Klaunig, J.E. Toxicol. Appl. Pharmacol. (1985) [Pubmed]
  16. Metabolic pathway engineering to enhance aerobic degradation of chlorinated ethenes and to reduce their toxicity by cloning a novel glutathione S-transferase, an evolved toluene o-monooxygenase, and gamma-glutamylcysteine synthetase. Rui, L., Kwon, Y.M., Reardon, K.F., Wood, T.K. Environ. Microbiol. (2004) [Pubmed]
  17. Aerobic biodegradation of vinyl chloride and cis-1,2-dichloroethylene in aquifer sediments. Broholm, K., Ludvigsen, L., Jensen, T.F., Østergaard, H. Chemosphere (2005) [Pubmed]
  18. Carcinogenicity of chlorinated methane and ethane compounds administered in drinking water to mice. Klaunig, J.E., Ruch, R.J., Pereira, M.A. Environ. Health Perspect. (1986) [Pubmed]
  19. Isolation and characterization of Dehalococcoides sp. strain FL2, a trichloroethene (TCE)- and 1,2-dichloroethene-respiring anaerobe. He, J., Sung, Y., Krajmalnik-Brown, R., Ritalahti, K.M., Löffler, F.E. Environ. Microbiol. (2005) [Pubmed]
  20. Analysis of halogenated hydrocarbons in trans-1,2-dichloroethylene by thick-film, wide-bore, capillary gas chromatography. Chatham, A.T., Brown, R.D., Mills, D.A. Bulletin of environmental contamination and toxicology. (1987) [Pubmed]
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