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Chemical Compound Review

SureCN7285292     N-[(Z)-3-(3-chloro-4- cyclohexyl...

Synonyms: AK-57806, SR-31747, AC1O5RG8, SR 31747, SR 31747A, ...
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Disease relevance of


High impact information on

  • Sterol isomerase activity is also inhibited by SR 31747 in in vitro assays [3].
  • SR 31747 is a novel immunosuppressant agent that arrests cell proliferation in the yeast Saccharomyces cerevisiae, SR 31747-treated cells accumulate the same aberrant sterols as those found in a mutant impaired in delta 8- delta 7-sterol isomerase [3].
  • The ERG2 gene product has been identified recently as the molecular target of SR 31747A that mediates antiproliferative effects of the drug in yeast [4].
  • SR 31747A, defined as a sigma ligand, is a novel immunosuppressive agent that blocks proliferation of human and mouse lymphocytes [4].
  • Using a radiolabeled chemical probe, we here purified a target of SR 31747A and called it SR 31747A-binding protein (SR-BP) [4].

Biological context of


Anatomical context of


Associations of with other chemical compounds


Gene context of


Analytical, diagnostic and therapeutic context of


  1. In vivo inhibition of endotoxin-induced pro-inflammatory cytokines production by the sigma ligand SR 31747. Derocq, J.M., Bourrié, B., Ségui, M., Le Fur, G., Casellas, P. J. Pharmacol. Exp. Ther. (1995) [Pubmed]
  2. Immunopharmacological profile of SR 31747: in vitro and in vivo studies on humoral and cellular responses. Casellas, P., Bourrié, B., Canat, X., Carayon, P., Buisson, I., Paul, R., Brelière, J.C., Le Fur, G. J. Neuroimmunol. (1994) [Pubmed]
  3. The immunosuppressant SR 31747 blocks cell proliferation by inhibiting a steroid isomerase in Saccharomyces cerevisiae. Silve, S., Leplatois, P., Josse, A., Dupuy, P.H., Lanau, C., Kaghad, M., Dhers, C., Picard, C., Rahier, A., Taton, M., Le Fur, G., Caput, D., Ferrara, P., Loison, G. Mol. Cell. Biol. (1996) [Pubmed]
  4. Purification and characterization of the human SR 31747A-binding protein. A nuclear membrane protein related to yeast sterol isomerase. Jbilo, O., Vidal, H., Paul, R., De Nys, N., Bensaid, M., Silve, S., Carayon, P., Davi, D., Galiègue, S., Bourrié, B., Guillemot, J.C., Ferrara, P., Loison, G., Maffrand, J.P., Le Fur, G., Casellas, P. J. Biol. Chem. (1997) [Pubmed]
  5. Allosteric modulation of peripheral sigma binding sites by a new selective ligand: SR 31747. Paul, R., Lavastre, S., Floutard, D., Floutard, R., Canat, X., Casellas, P., Le Fur, G., Brelière, J.C. J. Neuroimmunol. (1994) [Pubmed]
  6. Enhancement of endotoxin-induced interleukin-10 production by SR 31747A, a sigma ligand. Bourrie, B., Bouaboula, M., Benoit, J.M., Derocq, J.M., Esclangon, M., Le Fur, G., Casellas, P. Eur. J. Immunol. (1995) [Pubmed]
  7. Development of a radioimmunoassay for SR 31747A, a new sigma ligand, in human plasma. Dussossoy, D., Belugou, S., Pastor, G., Combalbert, J., Casellas, P. Journal of pharmaceutical and biomedical analysis. (1996) [Pubmed]
  8. The sigma ligand SR 31747 prevents the development of acute graft-versus-host disease in mice by blocking IFN-gamma and GM-CSF mRNA expression. Carayon, P., Bouaboula, M., Loubet, J.F., Bourrie, B., Petitpretre, G., Le Fur, G., Casellas, P. Int. J. Immunopharmacol. (1995) [Pubmed]
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