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Chemical Compound Review

D02073     methyl7-[(1R,2S,3R)-3- hydroxy-2-[(3R)-3...

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Disease relevance of D02073


High impact information on D02073

  • Mifepristone in oral doses of 400-600 mg was followed 48 h later by a gemeprost vaginal pessary (0.5-1.0 mg) [6].
  • The combination of mifepristone and gemeprost provides a safe and effective alternative to surgical evacuation of the uterus for therapeutic abortion in early pregnancy [6].
  • OBJECTIVE: We aimed to determine whether second-trimester abortion using isosorbide mononitrate (IMN) in addition to gemeprost is more effective and reduces side effects compared with gemeprost alone [7].
  • STUDY DESIGN: Eighty women who were age 13 to 23 weeks' gestation were randomly assigned to receive per vaginam either IMN 40 mg (group 1, 40 women) or placebo (group 2, 40 women) in addition to gemeprost 1 mg up to 3 times daily 3 hours apart for 2 days [7].
  • CONCLUSION: Vaginally administered misoprostol (400 microg) is as effective as gemeprost (1 mg) for cervical priming 3 to 4 hours before surgical termination of first-trimester pregnancies [8].

Chemical compound and disease context of D02073


Biological context of D02073


Anatomical context of D02073


Associations of D02073 with other chemical compounds


Gene context of D02073


Analytical, diagnostic and therapeutic context of D02073


  1. Randomised trial of nitric oxide donor versus prostaglandin for cervical ripening before first-trimester termination of pregnancy. Thomson, A.J., Lunan, C.B., Ledingham, M., Howat, R.C., Cameron, I.T., Greer, I.A., Norman, J.E. Lancet (1998) [Pubmed]
  2. Uterine rupture in midtrimester abortion. A complication of gemeprost vaginal pessaries and oxytocin. Case report. Thong, K.J., Baird, D.T. British journal of obstetrics and gynaecology. (1991) [Pubmed]
  3. Controlled study of 16,16-dimethyl-trans-delta 2 prostaglandin E1 methyl ester vaginal pessaries prior to suction termination of first trimester pregnancies. Fisher, P.R., Taylor, J.H. British journal of obstetrics and gynaecology. (1984) [Pubmed]
  4. Termination of a molar pregnancy using mifepristone and gemeprost. Bates, A., Pinto, A., Evans, J. British journal of obstetrics and gynaecology. (1994) [Pubmed]
  5. Treatment of severe postpartum hemorrhage by rectally administered gemeprost pessaries. Craig, S., Chau, H., Cho, H. Journal of perinatal medicine. (1999) [Pubmed]
  6. Induction of therapeutic abortion in early pregnancy with mifepristone in combination with prostaglandin pessary. Rodger, M.W., Baird, D.T. Lancet (1987) [Pubmed]
  7. Second trimester abortion using isosorbide mononitrate in addition to gemeprost compared with gemeprost alone: a double-blind randomized, placebo-controlled multicenter trial. Eppel, W., Facchinetti, F., Schleussner, E., Piccinini, F., Pizzi, C., Gruber, D.M., Schneider, B., Tschugguel, W. Am. J. Obstet. Gynecol. (2005) [Pubmed]
  8. Gemeprost versus misoprostol for cervical priming before first-trimester abortion: a randomized controlled trial. Ekerhovd, E., Radulovic, N., Norström, A. Obstetrics and gynecology. (2003) [Pubmed]
  9. Medical treatment for early fetal death (less than 24 weeks). Neilson, J.P., Hickey, M., Vazquez, J. Cochrane database of systematic reviews (Online) (2006) [Pubmed]
  10. Spontaneous abortion: a medical approach to management. Chung, T.K., Cheung, L.P., Lau, W.C., Haines, C.J., Chang, A.M. The Australian & New Zealand journal of obstetrics & gynaecology. (1994) [Pubmed]
  11. The effects of gemeprost on the second trimester fetus. Lazda, E.J., Sams, V.R. British journal of obstetrics and gynaecology. (1995) [Pubmed]
  12. Comparison of vaginal misoprostol and gemeprost as pre-treatment in first trimester pregnancy interruption. Henry, A.M., Haukkamaa, M. British journal of obstetrics and gynaecology. (1999) [Pubmed]
  13. Reducing the induction to abortion interval in termination of second trimester pregnancies: a comparison of mifepristone with laminaria tent. Ho, P.C., Tsang, S.S., Ma, H.K. British journal of obstetrics and gynaecology. (1995) [Pubmed]
  14. Pre-operative cervical preparation before first trimester vacuum aspiration: a randomized controlled comparison between gemeprost and mifepristone (RU 486). Henshaw, R.C., Templeton, A.A. British journal of obstetrics and gynaecology. (1991) [Pubmed]
  15. The use of gemeprost pessaries to arrest postpartum haemorrhage. Bates, A., Johansen, K. British journal of obstetrics and gynaecology. (1994) [Pubmed]
  16. Effects of gemeprost and mifepristone on the mechanical properties of the cervix prior to first trimester termination of pregnancy. Carbonne, B., Brennand, J.E., Maria, B., Cabrol, D., Calder, A.A. British journal of obstetrics and gynaecology. (1995) [Pubmed]
  17. Clinical effects and cervical tissue changes after treatment with 16,16 dimethyl-trans delta 2 PGE1 methylester in the first trimester. Ding, J.Q., Granberg, S., Norström, A. Prostaglandins (1990) [Pubmed]
  18. A comparison between two doses of intravaginal misoprostol and gemeprost for induction of second-trimester abortion. Nuutila, M., Toivonen, J., Ylikorkala, O., Halmesmäki, E. Obstetrics and gynecology. (1997) [Pubmed]
  19. Changes in the coelomic fluid composition following two different methods of cervical ripening. Gavriil, P., Jauniaux, E., Gulbis, B., Jurkovic, D., Meuris, S. Hum. Reprod. (1995) [Pubmed]
  20. Nitric oxide donors induce ripening of the human uterine cervix: a randomised controlled trial. Thomson, A.J., Lunan, C.B., Cameron, A.D., Cameron, I.T., Greer, I.A., Norman, J.E. British journal of obstetrics and gynaecology. (1997) [Pubmed]
  21. The use of progesterone antagonists in combination with prostaglandin for termination of pregnancy. Bygdeman, M., Swahn, M.L., Gemzell-Danielsson, K., Gottlieb, C. Hum. Reprod. (1994) [Pubmed]
  22. Circulating levels of placental protein 12 and chorionic gonadotrophin following RU 38486 and gemeprost for termination of first trimester pregnancy. Olajide, F., Howell, R.J., Wass, J.A., Holly, J.M., Bohn, H., Grudzinskas, J.G., Chapman, M.G., Chard, T. Hum. Reprod. (1989) [Pubmed]
  23. Circulating levels of placental protein 14 and progesterone following Mifepristone (RU38486) and Gemeprost for termination of first trimester pregnancy. Howell, R.J., Olajide, F., Teisner, B., Grudzinskas, G., Chard, T. Fertil. Steril. (1989) [Pubmed]
  24. Medical abortion or vacuum aspiration? Two year follow up of a patient preference trial. Howie, F.L., Henshaw, R.C., Naji, S.A., Russell, I.T., Templeton, A.A. British journal of obstetrics and gynaecology. (1997) [Pubmed]
  25. An effective regimen for early medical abortion: a report of 2000 consecutive cases. Ashok, P.W., Penney, G.C., Flett, G.M., Templeton, A. Hum. Reprod. (1998) [Pubmed]
  26. Double-blind randomized trial of mifepristone in combination with vaginal gemeprost or misoprostol for induction of abortion up to 63 days gestation. Bartley, J., Brown, A., Elton, R., Baird, D.T. Hum. Reprod. (2001) [Pubmed]
  27. A comparison of medical abortion (using mifepristone and gemeprost) with surgical vacuum aspiration: efficacy and early medical sequelae. Henshaw, R.C., Naji, S.A., Russell, I.T., Templeton, A.A. Hum. Reprod. (1994) [Pubmed]
  28. Changes in the concentration of alpha-fetoprotein and placental hormones following two methods of medical abortion in early pregnancy. Thong, K.J., Norman, J.E., Baird, D.T. British journal of obstetrics and gynaecology. (1993) [Pubmed]
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