Disease relevance of Uterine Rupture

• There was no difference in neonatal outcome, with the exception of a fetal death related to uterine rupture in the misoprostol group [1].
• Acta fifty years ago. Fistulas, pelvic hyperalgesia, uterine rupture and giant babies [2].
• The uterine rupture was heralded by a sudden onset of severe abdominal pain while she was receiving intravenous ritodrine [3].
• A patient is described in whom the symptoms and signs of uterine rupture were not masked by combined spinal epidural analgesia with an epidural infusion of 0.1% bupivacaine and 1.5 microg ml(-l) fentanyl [4].
• Ruptured advanced tubal ectopic pregnancy simulating uterine rupture: a case report [5].

High impact information on Uterine Rupture

• Uterine rupture due to 15-methylprostaglandin F2 alpha [6].
• Labor induction with misoprostol culminated in uterine rupture [7].
• There was a trend toward higher uterine rupture rates in those with induced versus spontaneous labor (0.7% versus 0.3%, P =.128) and for patients undergoing dinoprostone (prostaglandin E(2)) induction versus other methods (1.1% versus 0.6%, P =.62), although neither difference achieved statistical significance [8].
• METHODS: Using a perinatal database, all cases of uterine rupture in the province of Nova Scotia for the 10-year period 1988-1997 were identified and the maternal and perinatal mortality and morbidity reviewed in detail [9].
• There were no uterine ruptures with prostaglandin E2 [1].

Chemical compound and disease context of Uterine Rupture

• The association of oxytocin induction, oxytocin augmentation, and use of prostaglandin E(2) gel with uterine rupture was determined [10].
• Uterine rupture associated with recent antepartum cocaine abuse [11].
• The pain of uterine rupture was not masked by the addition of fentanyl 25 micrograms to bupivacaine 0.25% 6 ml but was relieved by bupivacaine 0.375% 6 ml [12].
• We report a case in which there was clinical and laboratory evidence of DIC in a patient with uterine rupture [13].
• A case is presented of uterine rupture in a patient exposed to DES in utero who had no known predisposing factors for uterine rupture [14].

Biological context of Uterine Rupture

• CONCLUSIONS: Compared with prostaglandin E2, misoprostol is more effective in cervical ripening and induction of labor, is as safe for patients who do not have a history of cesarean birth, may carry a higher incidence of uterine rupture, and should not be used for patients attempting vaginal birth after previous cesarean delivery [1].
• Third-trimester uterine rupture associated with vaginal prostaglandin E2 [15].
• Oral misoprostol and uterine rupture in the first trimester of pregnancy [16].
• Combined bladder and uterine rupture following prostaglandin-induced midtrimester abortion: an unreported event [17].
• OBJECTIVE: To review our experience with uterine rupture in patients undergoing a trial of labor with a history of previous cesarean delivery in which labor was induced with misoprostol [18].

Anatomical context of Uterine Rupture

• CONCLUSION: These cases and recent experiments on the effect of cocaine on the pregnant uterus suggest that antepartum cocaine abuse may increase the risk of uterine rupture [11].

Gene context of Uterine Rupture

• The incidence of uterine rupture was significantly higher among women with a prior cesarean (3.8% vs 0.2%, odds ratio 20.8, 95% confidence interval 14.1 to 104, p = 0.008) [19].
• Rupture of a nodule of hepatocellular carcinoma simulating uterine rupture in late pregnancy [20].
• Uterine rupture in labour. A 10-year review [21].
• We describe a case of spontaneous uterine rupture at 8 weeks' gestation in a 29-year-old woman, who has a history of systemic lupus erythematosus [22].
• MAIN OUTCOME MEASURES: Severe haemorrhage requiring blood transfusion, post-abortal infection, retained placenta and uterine rupture [23].

Analytical, diagnostic and therapeutic context of Uterine Rupture

• OBJECTIVE: This study was undertaken to determine the risk of uterine rupture in patients induced with oxytocin or misoprostol after 1 or more previous cesarean sections [24].
• The uterine rupture rate for patients attempting vaginal birth after cesarean section was significantly higher in those who received misoprostol, 5.6%, than in those who did not, 0.2% (1/423, P =.0001) [25].
• Among 3533 total patients, rates of uterine rupture were compared among 4 groups: oxytocin induction (n = 430), misoprostol induction (n = 142), spontaneous labor (n = 2523), and repeat cesarean section without labor (n = 438) [24].

References