Disease relevance of Pinacolyl methylphosphonofluoridate

• Sodium pentobarbital alteration of the toxicity and distribution of soman (pinacolyl methylphosphonofluoridate) in mice [1].
• The object of the study was to determine the pharmacological nature of pinacolyl methylphosphonofluoridate (soman)-induced hypothermia in mice [2].
• The ultrastructural alterations in CA3 pyramidal neurons induced by the irreversible organophosphorus anticholinesterase (OP anti-ChE) pinacolyl methylphosphonofluoridate (soman) and by hypoxia were examined in rat hippocampal slices [3].

High impact information on Pinacolyl methylphosphonofluoridate

• Wild-type BuChE was inhibited by soman (pinacolyl methylphosphonofluoridate) [4].
• Soman (pinacolyl methylphosphonofluoridate), a highly toxic organophosphate compound, has been found to be a strong inhibitor of hepatic microsomal carboxylesterase in vitro, but an enhancer of carboxylesterase when administered in vivo [5].
• Relationship between age of mice, enzymes such as acetylcholinesterase and aliesterase, and toxicity of soman (pinacolyl methylphosphonofluoridate) [6].
• Interaction of the four stereoisomers of soman (pinacolyl methylphosphonofluoridate) with acetylcholinesterase and neuropathy target esterase of hen brain [7].
• Heretofore, this DFPase was characterized by its more rapid hydrolysis of Soman (1,2,2-trimethylpropyl methylphosphonofluoridate), its stimulation by Mn2+, and its wide distribution [8].

Chemical compound and disease context of Pinacolyl methylphosphonofluoridate

• Various doses of CBDP (2-(2- methylphenoxy )-4H-1,3,2- benzodioxaphosphorin -2-oxide), a metabolite of tri-o-cresyl phosphate, increased dramatically the acute toxicity of soman ( pinacolyl methylphosphonofluoridate ) in mice [9].

Biological context of Pinacolyl methylphosphonofluoridate

• Concentrations of C(+/-)P(+/-)-soman (1,2,2-trimethylpropyl methylphosphonofluoridate) in urine of anaesthetized, atropinized and artificially ventilated rats, guinea pigs and marmosets were determined 1-4 h after iv administration of 1-6 LD50 of the agent and in the kidneys 1 h after iv administration of 2-6 LD50 14C-C(+/-)P(+/-)-soman [10].
• The effects of intravenous administration of the anticholinesterase agent soman (pinacolyl methylphosphonofluoridate, 3-15 micrograms/kg) on the visual evoked potential (VEP) were examined in cats using phase-reversed sine wave grating stimuli of different spatial frequencies and contrasts [11].
• The purpose of this investigation was to determine if there was a downregulation of the cholinergic receptors in mice following administration of a single dose of soman (pinacolyl methylphosphonofluoridate) or physostigmine [12].
• Effects of prior hypoxia acclimation (14-day at 380 mm Hg) on soman (pinacolyl methylphosphonofluoridate) induced brain neuronal RNA and acetylcholinesterase (AChE) depletion and lethality were monitored in rats following their return to ambient oxygenation [13].

Anatomical context of Pinacolyl methylphosphonofluoridate

• The influence of the organophosphate, soman (pinacolyl methylphosphonofluoridate), on neuritic growth and substrate utilization by mammalian autonomic neural tissue was studied using explants of the rat superior cervical ganglion as a model [14].
• Quantitative azure B-RNA cytophotometry was used to monitor metabolic responses of individual neurons of the motor cortex (layer V) and caudate nucleus of soman (pinacolyl methylphosphonofluoridate) poisoned rabbits [15].
• Extracellular acetylcholine (ACh) levels were determined, by intracranial microdialysis, in medial septum, amygdala and hippocampus (CA1, CA3, dentate gyrus) of rats during seizures induced by systemic administration of soman (pinacolyl methylphosphonofluoridate), a potent inhibitor of acetylcholinesterase (AChE) [16].
• Stereospecific reactivation of human brain and erythrocyte acetylcholinesterase inhibited by 1,2,2-trimethylpropyl methylphosphonofluoridate (soman) [17].
• An enzymatic activity that specifically hydrolyzes the highly toxic organophosphorus anticholinesterase compound soman (pinacolyl methylphosphonofluoridate) has been identified and partially characterized in the clonal neuronal neuroblastoma-glioma hybrid NG108-15 cell line [18].

Associations of Pinacolyl methylphosphonofluoridate with other chemical compounds

• Spontaneous recovery of central respiratory function was studied in anesthetized guinea pigs intoxicated with pinacolyl methylphosphonofluoridate (Soman) or isopropyl methylphosphonofluoridate (Sarin) [19].
• Effects of the acetylcholinesterase inhibitor pinacolyl methylphosphonofluoridate (soman) on selected endocrine, glucose, and catecholamine levels in fasted and fed rats [20].
• Effect of pyridostigmine and syntostigmine pretreatment on the inhibition of acetylcholinesterases by o-pinacolyl-methylphosphonofluoridate. In vitro experiments with rat tissues [21].
• Fine structural changes in cat neurohypophysis have been studied after single and multiple parenteral sub-LD50 doses of the organophosphates diisopropylfluorophosphate (DFP) and pinacolyl methylphosphonofluoridate (soman) [22].
• Protection from lethality and behavioral incapacitation resulting from intoxication by soman (pinacolyl methylphosphonofluoridate) and treatment with atropine sulfate and 2-PAM chloride in the guinea pig, cavia porcellus [23].

Gene context of Pinacolyl methylphosphonofluoridate

• Male Sprague-Dawley rats, injected with the irreversible acetylcholinesterase (AChE) inhibitor soman (pinacolyl methylphosphonofluoridate) 25 micrograms/kg sc, showed no signs of toxicity [24].
• Purified fetal bovine serum acetylcholinesterase (FBS AChE) and horse serum butyrylcholinesterase (BChE) were successfully used as single pretreatment drugs for the prevention of pinacolyl methylphosphonofluoridate (soman) toxicity in nonhuman primates [25].

Analytical, diagnostic and therapeutic context of Pinacolyl methylphosphonofluoridate

• Vascularization of some organs of rat following soman (O-pinacolyl methylphosphonofluoridate) intoxication was studied using scanning electron microscopy [26].

References