Disease relevance of LACTOBIONIC ACID

• In liver preservation, the substitution of the anion Cl(-) by lactobionic acid (LB) prevents reperfusion edema and extends the preservation time for human livers [1].
• Interaction between the sulfated lactobionic acid (LW 10082) and other antithrombotic agents in animal thrombosis model [2].

High impact information on LACTOBIONIC ACID

• Using two naturally derived SPSs (unfractionated heparin and low molecular weight heparin), one semi-synthetic SPS (pentosanpolysulfate), and one synthetic SPS (lactobionic acid) as well as the polypeptide hirudin we investigated the effect of these drugs on natural killer cell activity in vitro [3].
• Surface modification of magnetite nanoparticles using lactobionic acid and their interaction with hepatocytes [4].
• In order to solve this problem, lactobionic acid (LA) bearing galactose group was coupled with water-soluble chitosan (WSC) for liver specificity and poly(ethylenimine) (PEI) was combined to galactosylated chitosan (GC)/DNA complexes to enhance the transfection efficiency [5].
• In the HC II-mediated inhibition of thrombin, heparin and lactobionic acid both had strong inhibitory actions [6].
• Protamine sulfate neutralization of lactobionic acid amides [7].

Biological context of LACTOBIONIC ACID

• Influence of lactobionic acid on the kinetics of thrombin in human plasma [8].
• Nongrowing cells of Halobacterium saccharovorum oxidized lactose to a product identified as lactobionic acid by thin-layer, paper, and column chromatography, and by identification of the galactose and gluconic acid produced from it after acid hydrolysis [9].
• We studied the effect of compounds that are structurally related to lactobionic acid: anionic polycarbohydrates (sulfated anionic polysaccharide, SAP, and pentosan polysulfate, PPS) on liver function and leukocyte-endothelial cell interaction in isolated perfusion and liver transplant models [1].

Anatomical context of LACTOBIONIC ACID

• Lactobionic acid, bearing a beta -galactose group, was coupled with poly(allyl amine) to provide synthetic extracellular matrices together with poly(vinyl alcohol) (PVA) [10].

Associations of LACTOBIONIC ACID with other chemical compounds

• Pharmacodynamics of a sulfated lactobionic acid amide-derived antithrombotic agent (Aprosulate) in primates [11].
• In rats receiving constant-rate infusion of doxorubicin (30 micrograms/min), both the biliary and renal clearance of this drug dramatically decreased and its plasma concentrations increased after an intravenous injection of erythromycin lactobionic acid (100 mg/kg as erythromycin) [12].
• The conjugate was composed of lactobionic acid, diamine-terminated poly(ethylene glycol) and cholic acid (abbreviated as LEC) [13].

Gene context of LACTOBIONIC ACID

• Influence of hypersulfated lactobionic acid amides on tissue plasminogen activator release [14].
• Lactobionic acid, [4-beta-(galactosido)-D-gluconic acid] = LBA, is the major component of the Wisconsin organ transplantation preservant fluid and may suppress oxygen radical-induced tissue damage upon reperfusion by the control of FeII autoxidation [15].
• The limits of detection for raffinose and lactobionic acid were 1.0 ng (1.7 x 10(-12) mol, S/N = 3) and 2.0 ng (5.6 x 10(-12) mol, S/N = 3) respectively [16].

Analytical, diagnostic and therapeutic context of LACTOBIONIC ACID

• An anion exchange chromatographic method has been developed to quantify raffinose and lactobionic acid in ViaSpan, an organ preservation product [16].
• In the control group (n = 6), the heart-lung block underwent the same treatment as the experimental group except that lactobionic acid, raffinose and insulin were omitted from the storage solution, and that oxygen radical scavengers were excluded from the cardioplegic, pneumoplegic and storage solutions [17].

References