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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Organ Preservation

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Disease relevance of Organ Preservation


High impact information on Organ Preservation

  • To explore the possible benefits of cAMP analogs/agonists in organ preservation, we used a rat heterotopic cardiac transplant model; dibutyryl cAMP added to preservation solutions was associated with a time- and dose-dependent increase in the duration of cold storage associated with successful graft function [6].
  • To test the hypothesis that prior glucose loading of donor liver would optimize its adenosine triphosphate production and adenylate energy charge during ex vivo organ preservation, adult male rats were randomized to receive either intravenous dextrose or saline for 44 h [7].
  • The replacement of lactobionate by chloride had less untoward functional effects compared with studies of other solid organ preservation [8].
  • The University of Wisconsin solution differs from other types of solutions used for organ preservation because it contains high-energy phosphate precursors (adenosine and phosphate), impermeants (lactobionate and raffinose), an oncotic agent (pentafraction), and antioxidants (allopurinol and glutathione) [9].
  • CONCLUSION: Induction chemotherapy with PFL followed by concurrent cisplatin chemoradiotherapy is well tolerated and results in a good likelihood of organ preservation and excellent PFS and OS [10].

Biological context of Organ Preservation


Anatomical context of Organ Preservation


Associations of Organ Preservation with chemical compounds

  • In addition to being an antioxidant, GSH may exert its protective effects during organ preservation by inhibiting cytosolic proteases--perhaps via its glycine moiety [18].
  • The effect of cold storage of rat thoracic aortic rings in organ preservation solutions--a study of receptor-linked vascular prostacyclin synthesis [19].
  • These findings suggest that addition of verapamil to UW organ preservation solution may result in better poststorage liver function [20].
  • Histidine- and lactobionate-containing solutions thus represent a further improvement in organ preservation by simple cold storage [21].
  • Application of this principle to organ preservation has shown that supplementation with cyclic AMP analogs or inhibition of endogenous cAMP metabolism enables extension of the time a harvested organ can remain extracorporeally, after which transplantation is successful [22].

Gene context of Organ Preservation

  • The present study aims at a quantitative assessment of stress proteins, adhesion molecules, and interleukin-8 in a cell culture-based model of organ preservation [23].
  • p53 and p21 Expression levels predict organ preservation and survival in invasive bladder carcinoma treated with a combined-modality approach [24].
  • Of the lymphocyte subpopulations measured, CD8 levels were significantly lower in stage IV patients and tended to be lower in patients with successful organ preservation [25].
  • The full multivariate model for predicting larynx preservation in patients treated with induction chemotherapy plus radiation shows that T class, p53 overexpression, and elevated proliferating cell nuclear antigen index were independent predictors of successful organ preservation [26].
  • CONCLUSIONS: The author conclude that: (1) the current survival rate for genital MGCT is excellent, (2) delayed surgical resection with organ preservation is not associated with an adverse outcome, and (3) the treatment comparison of the effect of cisplatin dose was inconclusive in this small study population [27].

Analytical, diagnostic and therapeutic context of Organ Preservation


  1. Organ preservation solutions increase endothelial permeability and promote loss of junctional proteins. Trocha, S.D., Kevil, C.G., Mancini, M.C., Alexander, J.S. Ann. Surg. (1999) [Pubmed]
  2. Glucose-containing organ preservation solutions and intracellular acidosis. Fuller, B.J., Busza, A.L. Transplantation (1988) [Pubmed]
  3. Evaluation of chemotherapy response in patients with advanced head and neck cancer using [F-18]fluorodeoxyglucose positron emission tomography. Lowe, V.J., Dunphy, F.R., Varvares, M., Kim, H., Wittry, M., Dunphy, C.H., Dunleavy, T., McDonough, E., Minster, J., Fletcher, J.W., Boyd, J.H. Head & neck. (1997) [Pubmed]
  4. Bioenergetic targeting during organ preservation: (31)P magnetic resonance spectroscopy investigations into the use of fructose to sustain hepatic ATP turnover during cold hypoxia in porcine livers. Changani, K.K., Fuller, B.J., Bell, J.D., Taylor-Robinson, S., Davidson, B.R. Cryobiology (2000) [Pubmed]
  5. Are organ preservation and maintenance of sexual function compatible with optimal management of prostate cancer? Part 2--Advanced cancer. Pavone-Macaluso, M. Prog. Clin. Biol. Res. (1991) [Pubmed]
  6. Restoration of the cAMP second messenger pathway enhances cardiac preservation for transplantation in a heterotopic rat model. Pinsky, D., Oz, M., Liao, H., Morris, S., Brett, J., Sciacca, R., Karakurum, M., Van Lookeren Campagne, M., Platt, J., Nowygrod, R. J. Clin. Invest. (1993) [Pubmed]
  7. Decreased loss of liver adenosine triphosphate during hypothermic preservation in rats pretreated with glucose: implications for organ donor management. Palombo, J.D., Hirschberg, Y., Pomposelli, J.J., Blackburn, G.L., Zeisel, S.H., Bistrian, B.R. Gastroenterology (1988) [Pubmed]
  8. Compositional analysis of a modified University of Wisconsin solution for extended myocardial preservation. A study of the left ventricular pressure-volume relation. Ko, W., Zelano, J.A., Lazenby, W.D., Isom, O.W., Krieger, K.H. Circulation (1992) [Pubmed]
  9. Prolonged cardiac preservation. Evaluation of the University of Wisconsin preservation solution by comparison with the St. Thomas' Hospital cardioplegic solutions in the rat. Ledingham, S.J., Katayama, O., Lachno, D.R., Yacoub, M. Circulation (1990) [Pubmed]
  10. Cisplatin, fluorouracil, and leucovorin induction chemotherapy followed by concurrent cisplatin chemoradiotherapy for organ preservation and cure in patients with advanced head and neck cancer: long-term follow-up. Psyrri, A., Kwong, M., DiStasio, S., Lekakis, L., Kassar, M., Sasaki, C., Wilson, L.D., Haffty, B.G., Son, Y.H., Ross, D.A., Weinberger, P.M., Chung, G.G., Zelterman, D., Burtness, B.A., Cooper, D.L. J. Clin. Oncol. (2004) [Pubmed]
  11. Capillary electrophoresis in the evaluation of ischemic injury: simultaneous determination of purine compounds and glutathione. Carlucci, F., Tabucchi, A., Biagioli, B., Sani, G., Lisi, G., Maccherini, M., Rosi, F., Marinello, E. Electrophoresis (2000) [Pubmed]
  12. The role of enhanced mitochondrial phosphorylation in rat liver transplantation. Tanaka, A., Uyama, S., Tanaka, K., Katayama, T., Yamamoto, N., Yamaoka, Y., Ozawa, K. J. Surg. Res. (1992) [Pubmed]
  13. Three-dimensional morphological analysis of antigen-antibody reaction in hepatic sinusoids preserved in hypothermic UW solution. Sasaki, K., Johkura, K., Ogiwara, N., Liang, Y., Cui, L., Teng, R., Okouchi, Y., Asanuma, K., Ishida, O., Maruyama, K. Cryobiology (2001) [Pubmed]
  14. Idebenone protects hepatic microsomes against oxygen radical-mediated damage in organ preservation solutions. Wieland, E., Schütz, E., Armstrong, V.W., Küthe, F., Heller, C., Oellerich, M. Transplantation (1995) [Pubmed]
  15. Evaluation of preservation damage after porcine liver transplantation by assessment of hepatic microcirculation. Manner, M., Shult, W., Senninger, N., Machens, G., Otto, G. Transplantation (1990) [Pubmed]
  16. Oubain-sensitive adenosine triphosphatase from human kidneys. Nechay, B.R., Nelson, J.A., Contreras, R.R., Sarles, H.E., Remmers, A.R., Beathard, G.A., Fish, J.C., Lindley, J.D., Brady, J.M., Lerman, M.J. J. Pharmacol. Exp. Ther. (1975) [Pubmed]
  17. Potential impact on tumor control and organ preservation with cisplatin and 5-fluorouracil for patients with advanced tumors of the paranasal sinuses and nasal fossa. A prospective pilot study. Björk-Eriksson, T., Mercke, C., Petruson, B., Ekholm, S. Cancer (1992) [Pubmed]
  18. An increase in cytosolic protease activity during liver preservation. Inhibition by glutathione and glycine. Ferguson, D.M., Gores, G.J., Bronk, S.F., Krom, R.A. Transplantation (1993) [Pubmed]
  19. The effect of cold storage of rat thoracic aortic rings in organ preservation solutions--a study of receptor-linked vascular prostacyclin synthesis. Jeremy, J.Y., Stansby, G., Fuller, B., Rolles, K., Hamilton, G. Transplantation (1992) [Pubmed]
  20. 31P nuclear magnetic resonance spectroscopic evaluation of liver preservation solutions. Bowers, J.L., Neymark, E., Cook, C.U., Clouse, M.E. Transplantation (1994) [Pubmed]
  21. An examination of the effects of solutions containing histidine and lactobionate for heart, pancreas, and liver preservation in the rat. Sumimoto, R., Dohi, K., Urushihara, T., Jamieson, N.V., Ito, H., Sumimoto, K., Fukuda, Y. Transplantation (1992) [Pubmed]
  22. Hypoxia-induced modulation of endothelial cell properties: regulation of barrier function and expression of interleukin-6. Yan, S.F., Ogawa, S., Stern, D.M., Pinsky, D.J. Kidney Int. (1997) [Pubmed]
  23. Expression of stress proteins, adhesion molecules, and interleukin-8 in endothelial cells after preservation and reoxygenation. Eberl, T., Amberger, A., Herold, M., Hengster, P., Steurer, W., Hochleitner, B.W., Gnaiger, E., Margreiter, R. Cryobiology (1999) [Pubmed]
  24. p53 and p21 Expression levels predict organ preservation and survival in invasive bladder carcinoma treated with a combined-modality approach. Garcia del Muro, X., Condom, E., Vigués, F., Castellsagué, X., Figueras, A., Muñoz, J., Solá, J., Soler, T., Capellà, G., Germà, J.R. Cancer (2004) [Pubmed]
  25. Immune reactivity does not predict chemotherapy response, organ preservation, or survival in advanced laryngeal cancer. Wolf, G.T., Bradford, C.R., Urba, S., Smith, A., Eisbruch, A., Chepeha, D.B., Teknos, T.N., Worden, F., Dawson, L., Terrell, J.E., Hogikyan, N.D. Laryngoscope (2002) [Pubmed]
  26. Predictive markers for response to chemotherapy, organ preservation, and survival in patients with advanced laryngeal carcinoma. Bradford, C.R., Wolf, G.T., Carey, T.E., Zhu, S., Beals, T.F., Truelson, J.M., McClatchey, K.D., Fisher, S.G. Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery. (1999) [Pubmed]
  27. The effect of neoadjuvant chemotherapy and surgery in children with malignant germ cell tumors of the genital region: a pediatric intergroup trial. Rescorla, F., Billmire, D., Vinocur, C., Colombani, P., London, W., Giller, R., Cushing, B., Lauer, S., Cullen, J., Davis, M., Hawkins, E. J. Pediatr. Surg. (2003) [Pubmed]
  28. Immunomodulatory and cytoprotective function of atrial natriuretic peptide. Vollmar, A.M., Kiemer, A.K. Crit. Rev. Immunol. (2001) [Pubmed]
  29. Effect of glycine in dog and rat liver transplantation. den Butter, G., Lindell, S.L., Sumimoto, R., Schilling, M.K., Southard, J.H., Belzer, F.O. Transplantation (1993) [Pubmed]
  30. Quality control in planning and technique of radiotherapy with cobalt-60 for T1 glottic cancer increase local control and organ preservation. Cortes-Arroyo, H., Rodríguez-Cuevas, S., Labastida, S. Am. J. Surg. (1997) [Pubmed]
  31. Effect of glycine on isolated, perfused rabbit livers following 48-hour preservation in University of Wisconsin solution without glutathione. den Butter, G., Marsh, D.C., Lindell, S.L., Belzer, F.O., Southard, J.H. Transpl. Int. (1994) [Pubmed]
  32. Paradigm shift in the treatment of head and neck cancer: the role of neoadjuvant chemotherapy. Posner, M.R. Oncologist (2005) [Pubmed]
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