Disease relevance of ethoxymethanedithioic acid

• Various DNA and RNA virus species are inhibited by xanthate compounds at concentrations that leave the mitotic activity of uninfected cells unimpaired [1].
• The therapeutic efficacy of a xanthate compound on herpes simplex virus in skin lesions of mice and guinea-pigs [2].
• Antiviral effects of xanthate D609 on the human respiratory syncytial virus growth cycle [3].
• Antiviral xanthate causes conformational changes in simian virus 40 DNA and chromatin [4].
• Inhibition of the phosphorylation of the regulatory non-structural protein of vesicular stomatitis virus by an antiviral xanthate compound [5].

High impact information on ethoxymethanedithioic acid

• Ethylxanthate (1 mM) effectively inhibited the MC alkylation of NBP by hepatic nuclei but was unable to inhibit MC alkylation of NBP by tumor cell nuclei [6].
• Inhibitors of sphingolipid biosynthesis, such as fumonisin B(1) (FB(1)) and tricyclodecan-9-yl xanthate potassium salt (D609), also interfere with the trafficking of prosaposin to lysosomes [7].
• The xanthate compound D609 inhibited CK2 but not CK1 in vitro and had a very modest effect on P protein phosphorylation and RSV yield ex vivo [8].
• Interruption of growth signal transduction by an antiviral and antitumoral xanthate compound [9].
• Synthesis and structure-activity relationship of novel antitumoral platinum xanthate complexes [10].

Biological context of ethoxymethanedithioic acid

• At 100 mM, ethylxanthate produced a slight stimulation in the rate of MC alkylation of NBP [6].
• Here we examined the relationship between the site of ceramide deposition and inhibition of protein translation and induction of apoptosis by the antitumor/antiviral xanthate, D609 [11].
• [reaction: see text] A short synthesis of the tricyclic skeleton of pleuromutilin is reported, featuring an unusually efficient 8-endo-trig radical cyclization of a xanthate precursor [12].
• Dose-response kinetics revealed a synergistic interaction between the xanthate and the monocarbonic acid [13].
• In vivo protection by the xanthate tricyclodecan-9-yl-xanthogenate against amyloid beta-peptide (1-42)-induced oxidative stress [14].

Anatomical context of ethoxymethanedithioic acid

• The specific inhibitors of collagen biosynthesis 8,9-dihydroxy-7-methyl-benzo[b]quinolizinium bromide and tricyclodecane-9-yl xanthate arrested sea urchin embryo development at early blastula, prevented the invagination of the archenteron, and reverted the expression of type IV collagen-degrading activity to non-detectable levels [15].
• Antitumoral activity of a xanthate compound. I. Cytotoxicity studies with neoplastic cell lines in vitro [16].
• Both ethylxanthate and diethyldithiocarbamate can form highly lipophilic complexes with nickel and a facilitated penetration of these complexes through the cellular membranes of the tissues probably explains the increased uptake of the metal [17].
• Xanthate derivatives were shown previously to display antitumor activity against transformed fibroblasts and lymphoma cells in combination with monocarboxylic acids [1] [16].

Associations of ethoxymethanedithioic acid with other chemical compounds

• Without the cyano group, acid 26 and xanthate 27 were found to be more selective over Cdc25A (IC(50) = 5.1 microM and 1.1 microM, respectively) than toward CD45 (IC(50) > 100 microM, in each case), a receptor protein tyrosine phosphatase [18].
• Gamma-carbonyl vinyl boronates can be prepared by a visible light induced radical chain addition of an S-acyl dithiocarbonate (xanthate) to the pinacol ester of vinyl boronic acid, followed by treatment with base [19].
• Synthesis of tetrakis(cyclopropylmethyl)methane, a new symmetric product has been described using the radical mediated gem-diallylation of cyclopropylmethyl xanthate as a key step and its single crystal X-ray analysis established its C2-symmetry [20].
• [reaction: see text] Cyano(ethoxycarbonothioylthio)methyl benzoate 3 has been prepared and shown to be an excellent one-carbon radical equivalent that can be applied for the introduction of an acyl unit via xanthate transfer radical addition to olefins [21].
• The two xanthate complexes are characterized by (1)H NMR, IR, mass spectrometry, elemental analysis, and UV-vis techniques [22].

Gene context of ethoxymethanedithioic acid

• Thus, these results provide evidence that the xanthate inhibits a TPA-induced phospholipase C activity in the intact cell [23].
• The inactivation was mechanism-based and the loss in enzymatic activity was due to covalent binding of a reactive xanthate intermediate to the P450 2B1 apoprotein [24].
• Further, upon disulfide formation, dixanthogens are reduced by glutathione reductase to a redox active xanthate [25].
• With the exception of the C14 xanthate, virtually no loss of absorbance at 418 or 450 nm in the reduced-CO complex was observed [24].
• Interpretation of colloidal dyeing of polyester fabrics pretreated with ethyl xanthogenate in terms of zeta potential and surface free energy balance [26].

Analytical, diagnostic and therapeutic context of ethoxymethanedithioic acid

• Both HSV-1 DNA synthesis and virus production in the skin of guinea-pigs were also shown to be inhibited after treatment with the xanthate compound [2].
• Thermal gravimetric analysis (TGA) and differential thermal analysis (DTA) show that the gold xanthate complexes decompose to yield mainly gold metal at approximately 200 degrees C, confirmed by X-ray powder diffraction [22].
• Systemic treatment of a human epidermoid non-small cell lung carcinoma xenograft with a xanthate compound causes extensive intratumoral necrosis [27].

References