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Gene Review

c1546  -  repressor protein

Escherichia coli CFT073

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Disease relevance of c1546


High impact information on c1546

  • Regulation of transcription initiation is generally attributable to activator/repressor proteins that bind to specific DNA sequences [6].
  • We consider an example of an SOS repair system, and computationally infer the regulator activity of its master repressor, LexA [7].
  • In this work, a structure determined by x-ray crystallography of a complex of the repressor bound to biotin, which also functions as an activator of DNA binding by the biotin repressor (BirA), is described [8].
  • The results suggest that the corepressor of BirA causes a disorder-to-order transition that is a prerequisite to repressor dimerization and DNA binding [8].
  • ArsD is a trans-acting repressor of the arsRDABC operon that confers resistance to arsenicals and antimonials in Escherichia coli [9].

Chemical compound and disease context of c1546


Biological context of c1546

  • Repressor titration: a novel system for selection and stable maintenance of recombinant plasmids [14].
  • MALDI-TOF mass analysis identified it with IscR, known to serve as a repressor of the iscRSUA gene expression under anaerobic condition as a [2Fe-2S]-bound form [15].
  • Repressor binding to the fluorescein-labeled hairpin 20mer was compared with binding to a rhodamine-labeled 36 base-pair oligonucleotide bearing two inverted structural half-sites GNACT separated by an eight base-pair spacer containing none of the natural intervening sequence [16].
  • Both purified CysK and CymR, the global repressor of cysteine metabolism, were required to observe the formation of a protein-DNA complex with the yrrT promoter region in gel-shift experiments [17].
  • At the gadA promoter this regulatory element overlaps one of the binding sites of the repressor H-NS [18].

Associations of c1546 with chemical compounds

  • Repressor cysteines are reactive toward these reagents in the order cysteine 140 greater than or equal to cysteine 107 greater than cysteine 281 [19].
  • Mutations inactivating the Mnt repressor are recessive while those destroying operator recognition (Oc) are dominant in conferring tetracycline resistance on the host [20].
  • Deletion of fdsR revealed a dual regulatory effect of FdsR on the fds operon by acting as transcriptional activator in the presence of formate or as repressor in the absence of formate [21].
  • Glucose is a catabolite repressor of sporulation by C. perfringens [22].
  • Among others, two major regulators, the repressor Mlc and the cyclic AMP-cyclic AMP receptor protein activator complex, have been identified [23].

Analytical, diagnostic and therapeutic context of c1546


  1. Tracking of controlled Escherichia coli replication fork stalling and restart at repressor-bound DNA in vivo. Possoz, C., Filipe, S.R., Grainge, I., Sherratt, D.J. EMBO J. (2006) [Pubmed]
  2. Coordinated Regulation of the Neisseria gonorrhoeae-truncated Denitrification Pathway by the Nitric Oxide-sensitive Repressor, NsrR, and Nitrite-insensitive NarQ-NarP. Overton, T.W., Whitehead, R., Li, Y., Snyder, L.A., Saunders, N.J., Smith, H., Cole, J.A. J. Biol. Chem. (2006) [Pubmed]
  3. LfrR Is a Repressor That Regulates Expression of the Efflux Pump LfrA in Mycobacterium smegmatis. Buroni, S., Manina, G., Guglierame, P., Pasca, M.R., Riccardi, G., De Rossi, E. Antimicrob. Agents Chemother. (2006) [Pubmed]
  4. Cloning and characterization of SmeT, a repressor of the Stenotrophomonas maltophilia multidrug efflux pump SmeDEF. Sánchez, P., Alonso, A., Martinez, J.L. Antimicrob. Agents Chemother. (2002) [Pubmed]
  5. Comparison of the RpoH-dependent regulon and general stress response in Neisseria gonorrhoeae. Gunesekere, I.C., Kahler, C.M., Powell, D.R., Snyder, L.A., Saunders, N.J., Rood, J.I., Davies, J.K. J. Bacteriol. (2006) [Pubmed]
  6. rRNA promoter regulation by nonoptimal binding of sigma region 1.2: an additional recognition element for RNA polymerase. Haugen, S.P., Berkmen, M.B., Ross, W., Gaal, T., Ward, C., Gourse, R.L. Cell (2006) [Pubmed]
  7. Reconstructing repressor protein levels from expression of gene targets in Escherichia coli. Khanin, R., Vinciotti, V., Wit, E. Proc. Natl. Acad. Sci. U.S.A. (2006) [Pubmed]
  8. Corepressor-induced organization and assembly of the biotin repressor: a model for allosteric activation of a transcriptional regulator. Weaver, L.H., Kwon, K., Beckett, D., Matthews, B.W. Proc. Natl. Acad. Sci. U.S.A. (2001) [Pubmed]
  9. Evidence for cooperativity between the four binding sites of dimeric ArsD, an As(III)-responsive transcriptional regulator. Li, S., Rosen, B.P., Borges-Walmsley, M.I., Walmsley, A.R. J. Biol. Chem. (2002) [Pubmed]
  10. Coordinate Expression of the Acetyl Coenzyme A Carboxylase Genes, accB and accC, Is Necessary for Normal Regulation of Biotin Synthesis in Escherichia coli. Abdel-Hamid, A.M., Cronan, J.E. J. Bacteriol. (2007) [Pubmed]
  11. Repressor for the sn-glycerol 3-phosphate regulon of Escherichia coli K-12: primary structure and identification of the DNA-binding domain. Zeng, G., Ye, S., Larson, T.J. J. Bacteriol. (1996) [Pubmed]
  12. Differential DNA binding of transcriptional regulator PcaU from Acinetobacter sp. strain ADP1. Popp, R., Kohl, T., Patz, P., Trautwein, G., Gerischer, U. J. Bacteriol. (2002) [Pubmed]
  13. Implication of a repression system, homologous to those of other bacteria, in the control of arginine biosynthesis genes in Streptomyces coelicolor. Soutar, A., Baumberg, S. Mol. Gen. Genet. (1996) [Pubmed]
  14. Repressor titration: a novel system for selection and stable maintenance of recombinant plasmids. Williams, S.G., Cranenburgh, R.M., Weiss, A.M., Wrighton, C.J., Sherratt, D.J., Hanak, J.A. Nucleic Acids Res. (1998) [Pubmed]
  15. IscR acts as an activator in response to oxidative stress for the suf operon encoding Fe-S assembly proteins. Yeo, W.S., Lee, J.H., Lee, K.C., Roe, J.H. Mol. Microbiol. (2006) [Pubmed]
  16. Affinity and specificity of trp repressor-DNA interactions studied with fluorescent oligonucleotides. Reedstrom, R.J., Brown, M.P., Grillo, A., Roen, D., Royer, C.A. J. Mol. Biol. (1997) [Pubmed]
  17. Conversion of Methionine to Cysteine in Bacillus subtilis and Its Regulation. Hullo, M.F., Auger, S., Soutourina, O., Barzu, O., Yvon, M., Danchin, A., Martin-Verstraete, I. J. Bacteriol. (2007) [Pubmed]
  18. Mechanisms of Transcription Activation Exerted by GadX and GadW at the gadA and gadBC Gene Promoters of the Glutamate-Based Acid Resistance System in Escherichia coli. Tramonti, A., De Canio, M., Delany, I., Scarlato, V., De Biase, D. J. Bacteriol. (2006) [Pubmed]
  19. Chemical modification of lactose repressor protein using N-substituted maleimides. Brown, R.D., Matthews, K.S. J. Biol. Chem. (1979) [Pubmed]
  20. Role of plasmid multimers in mutation to tetracycline resistance. Boe, L., Marinus, M.G. Mol. Microbiol. (1991) [Pubmed]
  21. Dual control by regulatory gene fdsR of the fds operon encoding the NAD+-linked formate dehydrogenase of Ralstonia eutropha. Oh, J.I., Bowien, B. Mol. Microbiol. (1999) [Pubmed]
  22. The CcpA protein is necessary for efficient sporulation and enterotoxin gene (cpe) regulation in Clostridium perfringens. Varga, J., Stirewalt, V.L., Melville, S.B. J. Bacteriol. (2004) [Pubmed]
  23. YeeI, a novel protein involved in modulation of the activity of the glucose-phosphotransferase system in Escherichia coli K-12. Becker, A.K., Zeppenfeld, T., Staab, A., Seitz, S., Boos, W., Morita, T., Aiba, H., Mahr, K., Titgemeyer, F., Jahreis, K. J. Bacteriol. (2006) [Pubmed]
  24. Repression and catabolite repression of the lactose operon of Staphylococcus aureus. Oskouian, B., Stewart, G.C. J. Bacteriol. (1990) [Pubmed]
  25. Toxin-antitoxin regulation: bimodal interaction of YefM-YoeB with paired DNA palindromes exerts transcriptional autorepression. Kedzierska, B., Lian, L.Y., Hayes, F. Nucleic Acids Res. (2007) [Pubmed]
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