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Gene Review

CDO1  -  cysteine dioxygenase type 1

Homo sapiens

Synonyms: CDO, CDO-I, Cysteine dioxygenase type 1, Cysteine dioxygenase type I
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Disease relevance of CDO1

  • One cell line, TE 671 (human medulloblastoma) was found to express both a protein of approximately 70 kDa and CDO activity [1].
  • The characterization of an in vitro model for CDO expression provides a useful tool for the investigation of this important enzyme, which may have an etiological role in the pathogenesis of Parkinson's disease [1].
  • Using PSI-BLAST searches and crystallographic information about the active-site geometry of mammalian CDOs, we identified a total of four proteins from Bacillus subtilis, Bacillus cereus, and Streptomyces coelicolor A3(2) that shared low overall identity to CDO (13 to 21%) but nevertheless conserved important active-site residues [2].
  • Phylogenetic analyses of putative bacterial CDO homologs also indicate that CDO is distributed among species within the phyla of Actinobacteria, Firmicutes, and Proteobacteria [2].
  • We have examined the effect of this CDO alone and in combination with a range of common chemotherapeutic agents in colorectal cancer cell lines [3].

Psychiatry related information on CDO1


High impact information on CDO1


Chemical compound and disease context of CDO1


Biological context of CDO1


Anatomical context of CDO1


Associations of CDO1 with chemical compounds


Analytical, diagnostic and therapeutic context of CDO1

  • Nuclease protection assay (NPA) of mRNA isolated from TE 671 showed the expression of a CDO mRNA [1].
  • Simple drug-drug interaction studies showed that combining CDO with chemotherapy resulted in an enhancement of the antiproliferative effects [3].
  • METHODS: Antibodies and oligonucleotide probes raised against both CDO and SO were used for immunohistochemistry and in situ hybridisation, respectively, to investigate the expression of CDO and SO in human lung alveoli [12].


  1. Development of an in vitro model for cysteine dioxygenase expression in the brain. Qusti, S., Parsons, R.B., Abouglila, K.D., Waring, R.H., Williams, A.C., Ramsden, D.B. Cell Biol. Toxicol. (2000) [Pubmed]
  2. Identification and characterization of bacterial cysteine dioxygenases: a new route of cysteine degradation for eubacteria. Dominy, J.E., Simmons, C.R., Karplus, P.A., Gehring, A.M., Stipanuk, M.H. J. Bacteriol. (2006) [Pubmed]
  3. The in vitro effects of CRE-decoy oligonucleotides in combination with conventional chemotherapy in colorectal cancer cell lines. Liu, W.M., Scott, K.A., Shahin, S., Propper, D.J. Eur. J. Biochem. (2004) [Pubmed]
  4. Ablation of the mammalian methionine sulfoxide reductase A affects the expression level of cysteine deoxygenase. Oien, D.B., Moskovitz, J. Biochem. Biophys. Res. Commun. (2007) [Pubmed]
  5. Probes of the catalytic site of cysteine dioxygenase. Chai, S.C., Bruyere, J.R., Maroney, M.J. J. Biol. Chem. (2006) [Pubmed]
  6. Copper deficiency does not lead to taurine deficiency in rats. Ko, K.S., Tôrres, C.L., Fascetti, A.J., Stipanuk, M.H., Hirschberger, L., Rogers, Q.R. J. Nutr. (2006) [Pubmed]
  7. Cyclophosphamide, pegylated liposomal doxorubicin, vincristine and prednisone (CDOP) plus rituximab is effective and well tolerated in poor performance status elderly patients with non-Hodgkin's lymphoma. Visani, G., Guiducci, B., D'Adamo, F., Mele, A., Nicolini, G., Leopardi, G., Sparaventi, G., Barulli, S., Malerba, L., Isidori, A., Malagola, M., Piccaluga, P.P. Leuk. Lymphoma (2005) [Pubmed]
  8. Chromosomal localisation of genes coding for human and mouse liver cytosolic cysteine dioxygenase. Jeremiah, S., McCann, K.P., Williams, A.C., Ramsden, D.B., Pilz, A.J., Fox, M.F., Povey, S. Ann. Hum. Genet. (1996) [Pubmed]
  9. Human cysteine dioxygenase type I (CDO-I; EC 5' flanking region and intron-exon structure of the gene. Ramsden, D.B., Kapadi, A., Fitch, N.J., Farmer, M.J., Bennett, P., Williams, A.C. MP, Mol. Pathol. (1997) [Pubmed]
  10. Human cysteine dioxygenase type I: primary structure derived from base sequencing of cDNA. McCann, K.P., Akbari, M.T., Williams, A.C., Ramsden, D.B. Biochim. Biophys. Acta (1994) [Pubmed]
  11. Taurine biosynthetic enzymes and taurine transporter: molecular identification and regulations. Tappaz, M.L. Neurochem. Res. (2004) [Pubmed]
  12. Expression of cysteine dioxygenase (EC and sulfite oxidase in the human lung: a potential role for sulfate production in the protection from airborne xenobiotica. Millard, J., Parsons, R.B., Waring, R.H., Williams, A.C., Ramsden, D.B. MP, Mol. Pathol. (2003) [Pubmed]
  13. Taurine: new implications for an old amino acid. Schuller-Levis, G.B., Park, E. FEMS Microbiol. Lett. (2003) [Pubmed]
  14. Preparation, crystallization and X-ray diffraction analysis to 1.5 A resolution of rat cysteine dioxygenase, a mononuclear iron enzyme responsible for cysteine thiol oxidation. Simmons, C.R., Hao, Q., Stipanuk, M.H. Acta Crystallograph. Sect. F Struct. Biol. Cryst. Commun. (2005) [Pubmed]
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