The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

CD3EAP  -  CD3e molecule, epsilon associated protein

Homo sapiens

Synonyms: A34.5, ASE-1, ASE1, Antisense to ERCC-1 protein, CAST, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of CD3EAP


High impact information on CD3EAP

  • CAST/hPAF49 can interact with activator upstream binding factor (UBF) and, weakly, with selectivity factor 1 (SL1) at the rDNA (ribosomal DNA repeat sequence encoding the 18S, 5.8S, and 28S rRNA genes) promoter [5].
  • We provide evidence for growth-regulated Tyr phosphorylation of CAST/hPAF49, specifically in initiation-competent Pol Ibeta complexes in HeLa cells, at a conserved residue also known to be important for signaling during T-cell activation [5].
  • Specific transcription from the mouse rRNA promoter in vitro was severely impaired by anti-PAF49 antibody, which was overcome by addition of recombinant PAF49 protein [6].
  • The CLIP-170-like protein tip1p and the microtubule-bundling protein ase1p are required for this asymmetric regulation of microtubule dynamics, indicating contributions of factors both at microtubule plus ends and within the microtubule bundle [7].
  • Ase1 localizes to microtubule overlapping zones and displays dynamic alterations of localization during the cell cycle [8].

Biological context of CD3EAP


Anatomical context of CD3EAP

  • This indicates that suboptimal repair of both DNA mechanisms favors prolonged TTF and that polymorphism in ERCC2, XRCC3 and CD3EAP predicts the outcome for patients treated with autologous stem cell transplantation [1].
  • In contrast microtubule nucleating activities are not noticeably compromised in ase1 mutants [8].
  • We have investigated the ability of an antisense oligonucleotide (ASE-1) to specifically inhibit IgE synthesis by a human myeloma cell line, U266 [11].

Associations of CD3EAP with chemical compounds

  • ASE-1 was found to contain two domains that are present in a number of nucleolar specific proteins originating from a variety of organisms: a glycine-, arginine- and phenylalanine-rich putative nucleotide interaction domain and an alternating basic/acidic region [9].
  • The Aurora kinase does not correctly localize to central spindles in the absence of Ase1 [8].
  • METHODS: Cast specimens of aluminium bronzes with 1.4wt% Fe (G) and 4wt% Fe (N) were subject to progressively longer periods (up to in total 7 days) immersed in 0.1M saline, 0.1M lactic acid solutions and examined by scanning electron microscopy with EDX analysis [12].

Other interactions of CD3EAP


Analytical, diagnostic and therapeutic context of CD3EAP


  1. Polymorphisms in the genes ERCC2, XRCC3 and CD3EAP influence treatment outcome in multiple myeloma patients undergoing autologous bone marrow transplantation. Vangsted, A., Gimsing, P., Klausen, T.W., Nexø, B.A., Wallin, H., Andersen, P., Hokland, P., Lillevang, S.T., Vogel, U. Int. J. Cancer (2007) [Pubmed]
  2. The relationship of ASE-1 and NOR-90 in autoimmune sera. Whitehead, C.M., Fritzler, M.J., Rattner, J.B. J. Rheumatol. (1998) [Pubmed]
  3. ASE-1: an autoantigen in systemic lupus erythematosus. Edworthy, S., Fritzler, M., Whitehead, C., Martin, L., Rattner, J.B. Lupus (2000) [Pubmed]
  4. Gene-environment interactions between smoking and a haplotype of RAI, ASE-1 and ERCC1 polymorphisms among women in relation to risk of lung cancer in a population-based study. Vogel, U., S??rensen, M., Hansen, R.D., Tj??nneland, A., Overvad, K., Wallin, H., Nex??, B.A., Raaschou-Nielsen, O. Cancer Lett. (2007) [Pubmed]
  5. RNA polymerase I-specific subunit CAST/hPAF49 has a role in the activation of transcription by upstream binding factor. Panov, K.I., Panova, T.B., Gadal, O., Nishiyama, K., Saito, T., Russell, J., Zomerdijk, J.C. Mol. Cell. Biol. (2006) [Pubmed]
  6. Multiple protein-protein interactions by RNA polymerase I-associated factor PAF49 and role of PAF49 in rRNA transcription. Yamamoto, K., Yamamoto, M., Hanada, K., Nogi, Y., Matsuyama, T., Muramatsu, M. Mol. Cell. Biol. (2004) [Pubmed]
  7. Asymmetric microtubule pushing forces in nuclear centering. Daga, R.R., Yonetani, A., Chang, F. Curr. Biol. (2006) [Pubmed]
  8. The roles of fission yeast ase1 in mitotic cell division, meiotic nuclear oscillation, and cytokinesis checkpoint signaling. Yamashita, A., Sato, M., Fujita, A., Yamamoto, M., Toda, T. Mol. Biol. Cell (2005) [Pubmed]
  9. ASE-1: a novel protein of the fibrillar centres of the nucleolus and nucleolus organizer region of mitotic chromosomes. Whitehead, C.M., Winkfein, R.J., Fritzler, M.J., Rattner, J.B. Chromosoma (1997) [Pubmed]
  10. Association of an ERCC1 polymorphism with adult-onset glioma. Chen, P., Wiencke, J., Aldape, K., Kesler-Diaz, A., Miike, R., Kelsey, K., Lee, M., Liu, J., Wrensch, M. Cancer Epidemiol. Biomarkers Prev. (2000) [Pubmed]
  11. Specific inhibition of IgE antibody production by an antisense oligodeoxynucleotide oligomer (Oligostick). Hall, T.J., Brostoff, J. Immunology (1992) [Pubmed]
  12. Corrosion of dental aluminium bronze in neutral saline and saline lactic acid. Tibballs, J.E., Erimescu, R. Dental materials : official publication of the Academy of Dental Materials. (2006) [Pubmed]
  13. Effects of polymorphisms in ERCC1, ASE-1 and RAI on the risk of colorectal carcinomas and adenomas: a case control study. Skjelbred, C.F., Saebø, M., Nexø, B.A., Wallin, H., Hansteen, I.L., Vogel, U., Kure, E.H. BMC Cancer (2006) [Pubmed]
WikiGenes - Universities