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Gene Review

Chaf1b  -  chromatin assembly factor 1, subunit B (p60)

Mus musculus

Synonyms: 2600017H24Rik, C76145, CAF-1 subunit B, CAF-I 60 kDa subunit, CAF-I p60, ...
 
 
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Disease relevance of Chaf1b

  • Nine of 11 CAF1/J mice injected with purified canine cardiac SR-ATPase protein demonstrated myocardial lesions: 3 of 4 mice had occasional perivascular and/or interstitial mononuclear cell infiltrates after 3 weeks, 3 of 4 had borderline myocarditis after 6 weeks, and 3 of 3 had focal myocarditis after 12 weeks [1].
  • To test whether the protective Ags to Yersinia pestis can be orally delivered, the Y. pestis caf1 operon, encoding the F1-Ag and virulence Ag (V-Ag) were cloned into attenuated Salmonella vaccine vectors [2].
  • Hence, a new Salmonella vaccine, Salmonella-(F1+V)Ags, made with a single plasmid containing the caf1 operon and the chimeric promoter for V-Ag allowed the simultaneous expression of F1 capsule and V-Ag [2].
  • The growth of an ascitic murine plasmacytoma, MOPC 315, can be retarded in CAF1 hybrid host mice by the i.p. injection of donor lymphoid cells [3].
  • Repeated injections of busulfan (Bu) in CAF1 mice caused a long-lasting (greater than 16 weeks) decrease in their natural killer (NK) cell activity and impaired their resistance to transplantable lymphoma [4].
 

High impact information on Chaf1b

  • T cells from CAF1 mice immunized with various amounts of the type 2 antigen polyvinylpyrrolidone (PVP) were assessed for their ability to provide help to PVP-specific memory B cells for the production of IgG [5].
  • BALB/c stem cells grew as well in B6 mice with tumors as in CAF1 primary hosts but were rejected by B6 controls [6].
  • METHODS AND RESULTS: Monoclonal antibody 4C11-20.21 (IgM class) specific for canine cardiac SR-ATPase (M(r) approximately 110 kD) was generated by immunization of CAF1/J mice with dog heart sarcoplasmic reticulum [1].
  • Cellulose ester membranes (CEM) were coated with stromal cells from bone marrow (BM) or bone and implanted intraperitoneally (IP) in CAF1 mice for intervals of 1 to 6 months [7].
  • F1-Ag expression was controlled under a promoter from the caf1 operon; two different promoters (P), PtetA in pV3, PphoP in pV4, as well as a chimera of the two in pV55 were tested [2].
 

Biological context of Chaf1b

  • An attenuated Salmonella typhimurium strain which expressed the F1 capsular antigen of Yersinia pestis was constructed by transformation of S. typhimurium SL3261 with plasmid pFGAL2a, a derivative of pUC18 which contained the caf1 gene without the leader sequence [8].
  • As well, on a different recipient strain (CAF1; H-2a/d), neonatal C3H-H-2o2/SfSn (H-2o2) skin cotransplants, sharing only background antigens and H-2Dk with the adult graft donor, caused a significant prolongation of adult graft survival relative to that seen on recipients bearing only a single adult graft (MSTs = 53 and 31 days; P < 0.05) [9].
  • We compared the immunogenicity of the engineered monomer with polymeric Caf1 in antigen presentation assays to CD4 T-cell hybridomas in vitro, as well as in the induction of antibody responses and protection against subcutaneous challenge with Y. pestis in vivo [10].
  • The humoral antibody response of CAF1 mice to low doses (1-100 micrograms) of egg albumin (EA) encapsulated in or covalently bound to the surface of liposomes was studied for three routes of administration [11].
  • The phylogeny of macrophage function: antigen uptake and degradation by peritoneal exudate cells of two amphibian species and CAF1 mice [12].
 

Anatomical context of Chaf1b

  • In this paper we show that such CAF1 mice are resistant to the growth of a CRIA-positive hybridoma that is lethal in normal or in immunized non-suppressed mice [13].
  • A/J or CAF1 mice that are suppressed with respect to an idiotype, CRIA, associated with anti-Ar antibodies, and hyperimmunized develop high concentrations of idiotype-suppressor T cells [13].
  • Peritoneal macrophages from CAF1 mice were found to stimulate BALB/c spleen cells poorly if present in comparable numbers or if they were cultured for 24 hours before adding responding cells [14].
  • Indomethacin and Ro 20-5720, two prostaglandin synthesis inhibitors, produced a several-fold enhancement of the primary immunoglobulin (Ig) M and IgG anti-sheep red blood cell plaque-forming cell (PFC) response in CAF1 mice [15].
  • Successful production of large numbers of monoclonal antibodies was achieved when mast cell deficient (w/wv and sl/sld) but not conventional (BALB/c, CAF1 or SJL) mice were used [16].
 

Analytical, diagnostic and therapeutic context of Chaf1b

  • We have now examined the effect of this pretreatment in three allogeneic strain combinations of mice, namely, A leads to C57, CBA leads to CAF1, and CBA leads to BALB/c. Acute GVHD mortality at 15 days postirradiation and transplantation of untreated marrow and spleen cells was 100% in all the strain combinations [17].
  • The nucleotide sequences encoding Yersinia pestis V antigen (lcrV) and the mature form of F1 antigen (caf1) were amplified by PCR with primers which included tails [18].

References

  1. Cardiac sarcoplasmic reticulum calcium ATPase, an autoimmune antigen in experimental cardiomyopathy. Sharaf, A.R., Narula, J., Nicol, P.D., Southern, J.F., Khaw, B.A. Circulation (1994) [Pubmed]
  2. Oral Vaccination with Salmonella Simultaneously Expressing Yersinia pestis F1 and V Antigens Protects against Bubonic and Pneumonic Plague. Yang, X., Hinnebusch, B.J., Trunkle, T., Bosio, C.M., Suo, Z., Tighe, M., Harmsen, A., Becker, T., Crist, K., Walters, N., Avci, R., Pascual, D.W. J. Immunol. (2007) [Pubmed]
  3. The allogeneic effect on tumor growth. II. Suppression of both ascitic and solid MOPC 315 plasmacytoma by the graft-vs-host reaction, with pathologic correlation. Osborne, D.P., Katz, D.H. J. Immunol. (1977) [Pubmed]
  4. Effects of bone marrow transplantation and polyinosinic-polycytidylic acid (poly I:C) on the rescue of animals from busulfan-induced NK suppression. Bhoopalam, N., Fried, W., Benson, D., Barone-Verales, J., Price, K. Exp. Hematol. (1989) [Pubmed]
  5. Regulation of IgG memory responses by helper and suppressor T cells activated by the type 2 antigen, polyvinylpyrrolidone. Braley-Mullen, H. J. Exp. Med. (1985) [Pubmed]
  6. Loss of marrow allograft resistance in mice with transplanted methylcholanthrene-induced sarcomas. Kumar, V., Bennett, M. J. Natl. Cancer Inst. (1975) [Pubmed]
  7. Hematopoiesis on cellulose ester membranes. XI. Induction of new bone and a hematopoietic microenvironment by matrix factors secreted by marrow stromal cells. Knospe, W.H., Husseini, S.G., Fried, W. Blood (1989) [Pubmed]
  8. Immunization with live recombinant Salmonella typhimurium aroA producing F1 antigen protects against plague. Oyston, P.C., Williamson, E.D., Leary, S.E., Eley, S.M., Griffin, K.F., Titball, R.W. Infect. Immun. (1995) [Pubmed]
  9. Prolonged adult skin allograft survival as a result of cotransplantation with neonatal tissue. The requirement for antigen sharing between graft and cotransplant. Markees, T.G., De Fazio, S.R., Gozzo, J.J. Transplantation (1992) [Pubmed]
  10. Immunogenicity of a Yersinia pestis Vaccine Antigen Monomerized by Circular Permutation. Chalton, D.A., Musson, J.A., Flick-Smith, H., Walker, N., McGregor, A., Lamb, H.K., Williamson, E.D., Miller, J., Robinson, J.H., Lakey, J.H. Infect. Immun. (2006) [Pubmed]
  11. Antibody responses to liposome-associated antigen. Vannier, W.E., Snyder, S.L. Immunol. Lett. (1988) [Pubmed]
  12. The phylogeny of macrophage function: antigen uptake and degradation by peritoneal exudate cells of two amphibian species and CAF1 mice. Gammie, A.E., Ruben, L.N. Cell. Immunol. (1986) [Pubmed]
  13. Adoptive transfer of resistance to growth of an idiotype-secreting hybridoma by T cells from idiotypically suppressed mice. Kresina, T.F., Baine, Y., Nisonoff, A. J. Immunol. (1983) [Pubmed]
  14. Is the macrophage the stimulating cell? Talmage, D.W., Hemmingsen, H. J. Allergy Clin. Immunol. (1975) [Pubmed]
  15. Effects of prostaglandin synthesis inhibition on the immune response. Schleimer, R.P., Benjamini, E. Immunopharmacology (1981) [Pubmed]
  16. Production of large numbers of hybridomas producing monoclonal antibodies against rat IgE using mast cell-deficient w/wv and sl/sld strains of mice. Rup, B.J. J. Immunol. Methods (1989) [Pubmed]
  17. Amelioration of graft-versus-host disease by pretreatment of allogeneic cells with Fab fragments. Kulkarni, S.S., Kulkarni, A.D., Gallagher, M.T., Trentin, J.J. Transplantation (1981) [Pubmed]
  18. Expression of an F1/V fusion protein in attenuated Salmonella typhimurium and protection of mice against plague. Leary, S.E., Griffin, K.F., Garmory, H.S., Williamson, E.D., Titball, R.W. Microb. Pathog. (1997) [Pubmed]
 
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