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Gene Review

CDC42EP1  -  CDC42 effector protein (Rho GTPase binding) 1

Homo sapiens

Synonyms: BORG5, Binder of Rho GTPases 5, Borg5, CEP1, Cdc42 effector protein 1, ...
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Disease relevance of CDC42EP1


High impact information on CDC42EP1


Biological context of CDC42EP1


Anatomical context of CDC42EP1

  • On this basis, we have designated this novel protein MSE55, for marrow stromal/endothelial cell protein with a molecular mass of 55,000 daltons [8].
  • cDNA cloning and molecular characterization of MSE55, a novel human serum constituent protein that displays bone marrow stromal/endothelial cell-specific expression [8].
  • Also, expression of the verprolin-cofilin-acidic domain of N-WASP, a downstream Cdc42 effector, in ECs completely interfered with vacuole and lumen formation [9].
  • Human fertility protein PUMILIO2 interacts in vitro with testis mRNA encoding Cdc42 effector 3 (CEP3) [10].
  • A study by Fukata et al. in the June 28th issue of Cell now shows that the Rac1/Cdc42 effector IQGAP1 captures microtubules by binding to CLIP170 [11].

Associations of CDC42EP1 with chemical compounds


Other interactions of CDC42EP1


Analytical, diagnostic and therapeutic context of CDC42EP1

  • During the treadmill test, the mean exercise time to submaximal exertion (Borg 5/10), exertion ratings and respiratory rate did not differ between pacing modes despite a significantly lower ventricular rate in the VVI,R mode [16].


  1. Activation of the CDC42 effector N-WASP by the Shigella flexneri IcsA protein promotes actin nucleation by Arp2/3 complex and bacterial actin-based motility. Egile, C., Loisel, T.P., Laurent, V., Li, R., Pantaloni, D., Sansonetti, P.J., Carlier, M.F. J. Cell Biol. (1999) [Pubmed]
  2. Myotonic dystrophy kinase-related Cdc42-binding kinase acts as a Cdc42 effector in promoting cytoskeletal reorganization. Leung, T., Chen, X.Q., Tan, I., Manser, E., Lim, L. Mol. Cell. Biol. (1998) [Pubmed]
  3. A t(1;19)(q10;p10) Mediates the Combined Deletions of 1p and 19q and Predicts a Better Prognosis of Patients with Oligodendroglioma. Jenkins, R.B., Blair, H., Ballman, K.V., Giannini, C., Arusell, R.M., Law, M., Flynn, H., Passe, S., Felten, S., Brown, P.D., Shaw, E.G., Buckner, J.C. Cancer Res. (2006) [Pubmed]
  4. Pak1 and PIX regulate contact inhibition during epithelial wound healing. Zegers, M.M., Forget, M.A., Chernoff, J., Mostov, K.E., ter Beest, M.B., Hansen, S.H. EMBO J. (2003) [Pubmed]
  5. MSE55, a Cdc42 effector protein, induces long cellular extensions in fibroblasts. Burbelo, P.D., Snow, D.M., Bahou, W., Spiegel, S. Proc. Natl. Acad. Sci. U.S.A. (1999) [Pubmed]
  6. Stimulation of M3 muscarinic receptors induces phosphorylation of the Cdc42 effector activated Cdc42Hs-associated kinase-1 via a Fyn tyrosine kinase signaling pathway. Linseman, D.A., Heidenreich, K.A., Fisher, S.K. J. Biol. Chem. (2001) [Pubmed]
  7. Involvement of Rho GTPases and their effectors in the secretory process of PC12 cells. Frantz, C., Coppola, T., Regazzi, R. Exp. Cell Res. (2002) [Pubmed]
  8. cDNA cloning and molecular characterization of MSE55, a novel human serum constituent protein that displays bone marrow stromal/endothelial cell-specific expression. Bahou, W.F., Campbell, A.D., Wicha, M.S. J. Biol. Chem. (1992) [Pubmed]
  9. The Cdc42 and Rac1 GTPases are required for capillary lumen formation in three-dimensional extracellular matrices. Bayless, K.J., Davis, G.E. J. Cell. Sci. (2002) [Pubmed]
  10. Human fertility protein PUMILIO2 interacts in vitro with testis mRNA encoding Cdc42 effector 3 (CEP3). Spik, A., Oczkowski, S., Olszak, A., Formanowicz, P., B??azewicz, J., Jaruzelska, J. Reproductive biology (2006) [Pubmed]
  11. How to grab a microtubule on the move. Brunner, D. Dev. Cell (2002) [Pubmed]
  12. Inhibitory effects of a dominant-interfering form of the Rho-GTPase Cdc42 in the chemoattractant-elicited signaling pathways leading to NADPH oxidase activation in differentiated HL-60 cells. Rabiet, M.J., Tardif, M., Braun, L., Boulay, F. Blood (2002) [Pubmed]
  13. Cdc42-interacting protein 4 mediates binding of the Wiskott-Aldrich syndrome protein to microtubules. Tian, L., Nelson, D.L., Stewart, D.M. J. Biol. Chem. (2000) [Pubmed]
  14. SNX9 as an adaptor for linking synaptojanin-1 to the Cdc42 effector ACK1. Yeow-Fong, L., Lim, L., Manser, E. FEBS Lett. (2005) [Pubmed]
  15. Ack1 Mediates Cdc42-dependent Cell Migration and Signaling to p130Cas. Modzelewska, K., Newman, L.P., Desai, R., Keely, P.J. J. Biol. Chem. (2006) [Pubmed]
  16. A double-blind study of submaximal exercise tolerance and variation in paced rate in atrial synchronous compared to activity sensor modulated ventricular pacing. Linde-Edelstam, C., Nordlander, R., Pehrsson, S.K., Rydén, L. Pacing and clinical electrophysiology : PACE. (1992) [Pubmed]
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