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Gene Review

POLI  -  polymerase (DNA directed) iota

Homo sapiens

Synonyms: DNA polymerase iota, Eta2, RAD30 homolog B, RAD30B, RAD3OB
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Disease relevance of POLI


High impact information on POLI


Chemical compound and disease context of POLI

  • Our study shows the development of myomas in three patients without uterine pathology before tamoxifen therapy, and the increase of a polip and a myoma after tamoxifen therapy [10].

Biological context of POLI


Anatomical context of POLI

  • The human RAD30B and mouse Rad30b mRNA transcripts, like many repair proteins, are highly expressed in the testis [11].

Associations of POLI with chemical compounds

  • Translesion replication of benzo[a]pyrene and benzo[c]phenanthrene diol epoxide adducts of deoxyadenosine and deoxyguanosine by human DNA polymerase iota [15].
  • Composite specimens were prepared and polished with Poli I and Poli II aluminum oxide pastes, Ultralap diamond paste, Enhance finishing points, Politip rubber polishers, fine and extra fine diamond burs, and 30-blade tungsten carbide burs according to the manufacturers' instructions [16].
  • The etiology of POLIP/MNGIE syndrome appears therefore to be due to a mitochondrial cytopathy secondary to thymidine phosphorylase gene mutation(s) [17].
  • An incoming nucleotide imposes an anti to syn conformational change on the templating purine in the human DNA polymerase-iota active site [18].
  • Mussels (Mytilus galloprovincialis Lam.) and scallops (Flexopecten flexuosus Poli) were exposed, in a time to death test, to their LC85 of fenitrothion for 96 h [19].

Other interactions of POLI


Analytical, diagnostic and therapeutic context of POLI

  • Genomic sequence analysis of Poli led to the serendipitous discovery that 129-derived strains of mice have a nonsense codon mutation in exon 2 that abrogates production of poliota [22].
  • A reason for concern is that poli-pharmacy and excessive use of injectables continued [23].


  1. Association of amino acid substitution polymorphisms in DNA repair genes TP53, POLI, REV1 and LIG4 with lung cancer risk. Sakiyama, T., Kohno, T., Mimaki, S., Ohta, T., Yanagitani, N., Sobue, T., Kunitoh, H., Saito, R., Shimizu, K., Hirama, C., Kimura, J., Maeno, G., Hirose, H., Eguchi, T., Saito, D., Ohki, M., Yokota, J. Int. J. Cancer (2005) [Pubmed]
  2. Genome sequence and splice site analysis of low-fidelity DNA polymerases H and I involved in replication of damaged DNA. Cleaver, J.E., Collins, C., Ellis, J., Volik, S. Genomics (2003) [Pubmed]
  3. Induction of somatic hypermutation in immunoglobulin genes is dependent on DNA polymerase iota. Faili, A., Aoufouchi, S., Flatter, E., Guéranger, Q., Reynaud, C.A., Weill, J.C. Nature (2002) [Pubmed]
  4. Altered DNA polymerase iota expression in breast cancer cells leads to a reduction in DNA replication fidelity and a higher rate of mutagenesis. Yang, J., Chen, Z., Liu, Y., Hickey, R.J., Malkas, L.H. Cancer Res. (2004) [Pubmed]
  5. Polyneuropathy, ophthalmoplegia, leukoencephalopathy, and intestinal pseudo-obstruction: POLIP syndrome. Simon, L.T., Horoupian, D.S., Dorfman, L.J., Marks, M., Herrick, M.K., Wasserstein, P., Smith, M.E. Ann. Neurol. (1990) [Pubmed]
  6. Eukaryotic polymerases iota and zeta act sequentially to bypass DNA lesions. Johnson, R.E., Washington, M.T., Haracska, L., Prakash, S., Prakash, L. Nature (2000) [Pubmed]
  7. Biochemical evidence for the requirement of Hoogsteen base pairing for replication by human DNA polymerase iota. Johnson, R.E., Prakash, L., Prakash, S. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
  8. Targeting of human DNA polymerase iota to the replication machinery via interaction with PCNA. Haracska, L., Johnson, R.E., Unk, I., Phillips, B.B., Hurwitz, J., Prakash, L., Prakash, S. Proc. Natl. Acad. Sci. U.S.A. (2001) [Pubmed]
  9. Expression of activation-induced cytidine deaminase is confined to B-cell non-Hodgkin's lymphomas of germinal-center phenotype. Smit, L.A., Bende, R.J., Aten, J., Guikema, J.E., Aarts, W.M., van Noesel, C.J. Cancer Res. (2003) [Pubmed]
  10. Uterine changes during tamoxifen therapy. Rullo, S., Tagliaferri, T., Bandiera, F., Fiorelli, C., Felici, A., Piccioni, M.G., Framarino dei Malatesta, M.L. Clinical and experimental obstetrics & gynecology. (1993) [Pubmed]
  11. Novel human and mouse homologs of Saccharomyces cerevisiae DNA polymerase eta. McDonald, J.P., Rapić-Otrin, V., Epstein, J.A., Broughton, B.C., Wang, X., Lehmann, A.R., Wolgemuth, D.J., Woodgate, R. Genomics (1999) [Pubmed]
  12. Replication past a trans-4-hydroxynonenal minor-groove adduct by the sequential action of human DNA polymerases iota and kappa. Wolfle, W.T., Johnson, R.E., Minko, I.G., Lloyd, R.S., Prakash, S., Prakash, L. Mol. Cell. Biol. (2006) [Pubmed]
  13. Localization of the deoxyribose phosphate lyase active site in human DNA polymerase iota by controlled proteolysis. Prasad, R., Bebenek, K., Hou, E., Shock, D.D., Beard, W.A., Woodgate, R., Kunkel, T.A., Wilson, S.H. J. Biol. Chem. (2003) [Pubmed]
  14. A false note of DNA polymerase iota in the choir of genome caretakers in mammals. Gening, L.V., Makarova, A.V., Malashenko, A.M., Tarantul, V.Z. Biochemistry Mosc. (2006) [Pubmed]
  15. Translesion replication of benzo[a]pyrene and benzo[c]phenanthrene diol epoxide adducts of deoxyadenosine and deoxyguanosine by human DNA polymerase iota. Frank, E.G., Sayer, J.M., Kroth, H., Ohashi, E., Ohmori, H., Jerina, D.M., Woodgate, R. Nucleic Acids Res. (2002) [Pubmed]
  16. Effects of various finishing systems on the surface roughness and staining susceptibility of packable composite resins. Reis, A.F., Giannini, M., Lovadino, J.R., Ambrosano, G.M. Dental materials : official publication of the Academy of Dental Materials. (2003) [Pubmed]
  17. Digestive smooth muscle mitochondrial myopathy in patients with mitochondrial-neuro-gastro-intestinal encephalomyopathy (MNGIE). Blondon, H., Polivka, M., Joly, F., Flourie, B., Mikol, J., Messing, B. Gastroenterol. Clin. Biol. (2005) [Pubmed]
  18. An incoming nucleotide imposes an anti to syn conformational change on the templating purine in the human DNA polymerase-iota active site. Nair, D.T., Johnson, R.E., Prakash, L., Prakash, S., Aggarwal, A.K. Structure (2006) [Pubmed]
  19. Impaired glutathione redox status is associated with decreased survival in two organophosphate-poisoned marine bivalves. Peña-Llopis, S., Ferrando, M.D., Peña, J.B. Chemosphere (2002) [Pubmed]
  20. Proliferating cell nuclear antigen-dependent coordination of the biological functions of human DNA polymerase iota. Vidal, A.E., Kannouche, P., Podust, V.N., Yang, W., Lehmann, A.R., Woodgate, R. J. Biol. Chem. (2004) [Pubmed]
  21. poliota, a remarkably error-prone human DNA polymerase. Tissier, A., McDonald, J.P., Frank, E.G., Woodgate, R. Genes Dev. (2000) [Pubmed]
  22. 129-derived strains of mice are deficient in DNA polymerase iota and have normal immunoglobulin hypermutation. McDonald, J.P., Frank, E.G., Plosky, B.S., Rogozin, I.B., Masutani, C., Hanaoka, F., Woodgate, R., Gearhart, P.J. J. Exp. Med. (2003) [Pubmed]
  23. Improving government health services through contract management: a case from Cambodia. Soeters, R., Griffiths, F. Health policy and planning. (2003) [Pubmed]
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