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Gene Review

Bcan  -  brevican

Mus musculus

Synonyms: Brevican core protein, Cspg7
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Disease relevance of Bcan


High impact information on Bcan


Biological context of Bcan


Anatomical context of Bcan


Associations of Bcan with chemical compounds


Other interactions of Bcan

  • Further, an almost quadruple knockout like extracellular environment was noticed in the brains of triple knockout mice lacking both tenascins and brevican, since these brains had strongly reduced levels of neurocan [7].
  • These patterns were also seen after immunoreaction for chondroitin proteoglycan domains, brevican and phosphacan, as well as after detection of hyaluronan and tenascin-R [8].
  • No consensus TATA sequence was found upstream of the first exon, and RNase protection experiments revealed multiple transcriptional start sites for the brevican gene [2].

Analytical, diagnostic and therapeutic context of Bcan

  • Molecular cloning of Bral2, a novel brain-specific link protein, and immunohistochemical colocalization with brevican in perineuronal nets [9].


  1. Brevican-deficient mice display impaired hippocampal CA1 long-term potentiation but show no obvious deficits in learning and memory. Brakebusch, C., Seidenbecher, C.I., Asztely, F., Rauch, U., Matthies, H., Meyer, H., Krug, M., Böckers, T.M., Zhou, X., Kreutz, M.R., Montag, D., Gundelfinger, E.D., Fässler, R. Mol. Cell. Biol. (2002) [Pubmed]
  2. Sequence and chromosomal localization of the mouse brevican gene. Rauch, U., Meyer, H., Brakebusch, C., Seidenbecher, C., Gundelfinger, E.D., Beier, D.R., Fässler, R. Genomics (1997) [Pubmed]
  3. Lesion-induced differential expression and cell association of Neurocan, Brevican, Versican V1 and V2 in the mouse dorsal root entry zone. Beggah, A.T., Dours-Zimmermann, M.T., Barras, F.M., Brosius, A., Zimmermann, D.R., Zurn, A.D. Neuroscience (2005) [Pubmed]
  4. Xenopus brevican is expressed in the notochord and the brain during early embryogenesis. Sander, V., Müllegger, J., Lepperdinger, G. Mech. Dev. (2001) [Pubmed]
  5. Evidence for proteolytic cleavage of brevican by the ADAMTSs in the dentate gyrus after excitotoxic lesion of the mouse entorhinal cortex. Mayer, J., Hamel, M.G., Gottschall, P.E. BMC neuroscience [electronic resource]. (2005) [Pubmed]
  6. Neurocan is a heparin binding proteoglycan. Feng, K., Arnold-Ammer, I., Rauch, U. Biochem. Biophys. Res. Commun. (2000) [Pubmed]
  7. Extracellular matrix alterations in brains lacking four of its components. Rauch, U., Zhou, X.H., Roos, G. Biochem. Biophys. Res. Commun. (2005) [Pubmed]
  8. Region and lamina-specific distribution of extracellular matrix proteoglycans, hyaluronan and tenascin-R in the mouse hippocampal formation. Brückner, G., Grosche, J., Hartlage-Rübsamen, M., Schmidt, S., Schachner, M. J. Chem. Neuroanat. (2003) [Pubmed]
  9. Molecular cloning of Bral2, a novel brain-specific link protein, and immunohistochemical colocalization with brevican in perineuronal nets. Bekku, Y., Su, W.D., Hirakawa, S., Fässler, R., Ohtsuka, A., Kang, J.S., Sanders, J., Murakami, T., Ninomiya, Y., Oohashi, T. Mol. Cell. Neurosci. (2003) [Pubmed]
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