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Gene Review

BCAN  -  brevican

Homo sapiens

Synonyms: BEHAB, Brain-enriched hyaluronan-binding protein, Brevican core protein, CSPG7, Chondroitin sulfate proteoglycan 7, ...
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Disease relevance of BCAN


High impact information on BCAN

  • Thus far these proteoglycans include versican, neurocan, and brevican [5].
  • BEHAB/brevican: a brain-specific lectican implicated in gliomas and glial cell motility [6].
  • Here we describe for the first time the expression of BEHAB/brevican in human brain and characterize two novel glioma-specific isoforms, B/b(sia) and B/b(Deltag), which are generated by differential glycosylation and are absent from normal adult brain and other neuropathologies [1].
  • A role for this protein in glioma cell invasion was tested by transfecting a noninvasive cell line with the BEHAB/brevican gene [7].
  • Similar aggregates (potentially containing new members of the link protein family), in which other chondroitin sulfate proteoglycans (i.e. versican, brevican, and neurocan) substitute for aggrecan, may contribute to the structural integrity of many other tissues including skin and brain [8].

Chemical compound and disease context of BCAN


Biological context of BCAN

  • Human BRAL1 and BCAN genes that belong to the link-module superfamily are tandemly arranged on chromosome 1q21-23 [9].
  • Interestingly, the polypeptide deduced from the open reading frame of the 3.3-kb transcript is truncated just carboxyl-terminal of the central domain of brevican and instead contains a putative glypiation signal [10].
  • Fourth, we confirm and extend previous studies from our laboratory, here demonstrating the upregulation of BEHAB/brevican mRNA in human glioma quantitatively [11].
  • First, BEHAB/brevican maps to human chromosome 1q31 [11].
  • No cDNAs encoding a GPI-anchored bcan variant could be isolated from that cDNA library [12].

Anatomical context of BCAN


Associations of BCAN with chemical compounds


Other interactions of BCAN


Analytical, diagnostic and therapeutic context of BCAN


  1. Novel tumor-specific isoforms of BEHAB/brevican identified in human malignant gliomas. Viapiano, M.S., Bi, W.L., Piepmeier, J., Hockfield, S., Matthews, R.T. Cancer Res. (2005) [Pubmed]
  2. Matrix-degrading proteases ADAMTS4 and ADAMTS5 (disintegrins and metalloproteinases with thrombospondin motifs 4 and 5) are expressed in human glioblastomas. Held-Feindt, J., Paredes, E.B., Blömer, U., Seidenbecher, C., Stark, A.M., Mehdorn, H.M., Mentlein, R. Int. J. Cancer (2006) [Pubmed]
  3. Intracranial injury acutely induces the expression of the secreted isoform of the CNS-specific hyaluronan-binding protein BEHAB/brevican. Jaworski, D.M., Kelly, G.M., Hockfield, S. Exp. Neurol. (1999) [Pubmed]
  4. Glial tumor invasion: a role for the upregulation and cleavage of BEHAB/brevican. Nutt, C.L., Matthews, R.T., Hockfield, S. The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry. (2001) [Pubmed]
  5. Domain organization, genomic structure, evolution, and regulation of expression of the aggrecan gene family. Schwartz, N.B., Pirok, E.W., Mensch, J.R., Domowicz, M.S. Prog. Nucleic Acid Res. Mol. Biol. (1999) [Pubmed]
  6. BEHAB/brevican: a brain-specific lectican implicated in gliomas and glial cell motility. Gary, S.C., Kelly, G.M., Hockfield, S. Curr. Opin. Neurobiol. (1998) [Pubmed]
  7. Expression of a cleaved brain-specific extracellular matrix protein mediates glioma cell invasion In vivo. Zhang, H., Kelly, G., Zerillo, C., Jaworski, D.M., Hockfield, S. J. Neurosci. (1998) [Pubmed]
  8. Expression and purification of functionally active hyaluronan-binding domains from human cartilage link protein, aggrecan and versican: formation of ternary complexes with defined hyaluronan oligosaccharides. Seyfried, N.T., McVey, G.F., Almond, A., Mahoney, D.J., Dudhia, J., Day, A.J. J. Biol. Chem. (2005) [Pubmed]
  9. Human BRAL1 and BCAN genes that belong to the link-module superfamily are tandemly arranged on chromosome 1q21-23. Nomoto, H., Oohashi, T., Hirakawa, S., Ueki, Y., Ohtsuki, H., Ninomiya, Y. Acta Med. Okayama (2002) [Pubmed]
  10. Brevican, a chondroitin sulfate proteoglycan of rat brain, occurs as secreted and cell surface glycosylphosphatidylinositol-anchored isoforms. Seidenbecher, C.I., Richter, K., Rauch, U., Fässler, R., Garner, C.C., Gundelfinger, E.D. J. Biol. Chem. (1995) [Pubmed]
  11. cDNA cloning, chromosomal localization, and expression analysis of human BEHAB/brevican, a brain specific proteoglycan regulated during cortical development and in glioma. Gary, S.C., Zerillo, C.A., Chiang, V.L., Gaw, J.U., Gray, G., Hockfield, S. Gene (2000) [Pubmed]
  12. Xenopus brevican is expressed in the notochord and the brain during early embryogenesis. Sander, V., Müllegger, J., Lepperdinger, G. Mech. Dev. (2001) [Pubmed]
  13. Brevican is degraded by matrix metalloproteinases and aggrecanase-1 (ADAMTS4) at different sites. Nakamura, H., Fujii, Y., Inoki, I., Sugimoto, K., Tanzawa, K., Matsuki, H., Miura, R., Yamaguchi, Y., Okada, Y. J. Biol. Chem. (2000) [Pubmed]
  14. Molecular cloning of brevican, a novel brain proteoglycan of the aggrecan/versican family. Yamada, H., Watanabe, K., Shimonaka, M., Yamaguchi, Y. J. Biol. Chem. (1994) [Pubmed]
  15. Brain-enriched hyaluronan binding (BEHAB)/brevican cleavage in a glioma cell line is mediated by a disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS) family member. Matthews, R.T., Gary, S.C., Zerillo, C., Pratta, M., Solomon, K., Arner, E.C., Hockfield, S. J. Biol. Chem. (2000) [Pubmed]
  16. Fibulin-1 is a ligand for the C-type lectin domains of aggrecan and versican. Aspberg, A., Adam, S., Kostka, G., Timpl, R., Heinegård, D. J. Biol. Chem. (1999) [Pubmed]
  17. Competition and cooperation between tenascin-R, lecticans and contactin 1 regulate neurite growth and morphology. Zacharias, U., Rauch, U. J. Cell. Sci. (2006) [Pubmed]
  18. Decomposition of dihaloacetonitriles in water solutions and fortified drinking water samples. Nikolaou, A.D., Golfinopoulos, S.K., Kostopoulou, M.N., Lekkas, T.D. Chemosphere (2000) [Pubmed]
  19. Brevican: a major proteoglycan in adult brain. Yamaguchi, Y. Perspectives on developmental neurobiology. (1996) [Pubmed]
  20. The proteoglycans aggrecan and Versican form networks with fibulin-2 through their lectin domain binding. Olin, A.I., Mörgelin, M., Sasaki, T., Timpl, R., Heinegård, D., Aspberg, A. J. Biol. Chem. (2001) [Pubmed]
  21. Secreted brevican mRNA is expressed in the adult rat pituitary. Dong, Y., Han, X., Xue, Y., Dong, B., Guo, X., Hu, G., Zhu, C., Lu, Y. Biochem. Biophys. Res. Commun. (2004) [Pubmed]
  22. The C-type lectin domains of lecticans, a family of aggregating chondroitin sulfate proteoglycans, bind tenascin-R by protein-protein interactions independent of carbohydrate moiety. Aspberg, A., Miura, R., Bourdoulous, S., Shimonaka, M., Heinegârd, D., Schachner, M., Ruoslahti, E., Yamaguchi, Y. Proc. Natl. Acad. Sci. U.S.A. (1997) [Pubmed]
  23. BEHAB (brain enriched hyaluronan binding) is expressed in surgical samples of glioma and in intracranial grafts of invasive glioma cell lines. Jaworski, D.M., Kelly, G.M., Piepmeier, J.M., Hockfield, S. Cancer Res. (1996) [Pubmed]
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