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Gene Review

Tnr  -  tenascin R

Mus musculus

Synonyms: J1-tenascin, Janusin, Neural recognition molecule J1-160/180, Restrictin, TN-R, ...
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Disease relevance of Tnr


High impact information on Tnr


Biological context of Tnr


Anatomical context of Tnr

  • Co-localization of the molecule with TN-R in the retina and optic nerve by immunocytochemistry suggests a functional relationship between the two molecules in vivo [8].
  • Inhibition of neurite outgrowth from hippocampal neurons by the phosphacan-related molecule in vitro is neutralized by TN-R when coated as a uniform substrate [8].
  • Furthermore, the phosphacan-related molecule neutralizes growth cone repulsion induced by TN-R coated as a sharp substrate boundary with or without prior treatment with chondroitinase ABC [8].
  • To test this hypothesis, we investigated adult mice constitutively deficient in the expression of TNC, TNR or both, using the facial nerve injury paradigm [9].
  • Reduced extracellular space in the brain of tenascin-R- and HNK-1-sulphotransferase deficient mice [13].

Associations of Tnr with chemical compounds


Physical interactions of Tnr


Regulatory relationships of Tnr

  • Our results provide strong evidence that TNC promotes and TNR impedes recovery after nerve lesion [9].

Other interactions of Tnr


Analytical, diagnostic and therapeutic context of Tnr


  1. Behavioral alterations in mice deficient for the extracellular matrix glycoprotein tenascin-R. Freitag, S., Schachner, M., Morellini, F. Behav. Brain Res. (2003) [Pubmed]
  2. Severe cognitive and motor coordination deficits in tenascin-R-deficient mice. Montag-Sallaz, M., Montag, D. Genes Brain Behav. (2003) [Pubmed]
  3. Influence of janusin and tenascin on growth cone behavior in vitro. Taylor, J., Pesheva, P., Schachner, M. J. Neurosci. Res. (1993) [Pubmed]
  4. Association of tenascin-R with murine brain myelin membranes: involvement of divalent cations. Pesheva, P., Probstmeier, R. Neurosci. Lett. (2000) [Pubmed]
  5. Tenascin-C, tenascin-R and tenascin-X: a family of talented proteins in search of functions. Erickson, H.P. Curr. Opin. Cell Biol. (1993) [Pubmed]
  6. Tenascin-R mediates activity-dependent recruitment of neuroblasts in the adult mouse forebrain. Saghatelyan, A., de Chevigny, A., Schachner, M., Lledo, P.M. Nat. Neurosci. (2004) [Pubmed]
  7. Tenascin-R is an intrinsic autocrine factor for oligodendrocyte differentiation and promotes cell adhesion by a sulfatide-mediated mechanism. Pesheva, P., Gloor, S., Schachner, M., Probstmeier, R. J. Neurosci. (1997) [Pubmed]
  8. Isolation of a tenascin-R binding protein from mouse brain membranes. A phosphacan-related chondroitin sulfate proteoglycan. Xiao, Z.C., Bartsch, U., Margolis, R.K., Rougon, G., Montag, D., Schachner, M. J. Biol. Chem. (1997) [Pubmed]
  9. Opposite impacts of tenascin-C and tenascin-R deficiency in mice on the functional outcome of facial nerve repair. Guntinas-Lichius, O., Angelov, D.N., Morellini, F., Lenzen, M., Skouras, E., Schachner, M., Irintchev, A. Eur. J. Neurosci. (2005) [Pubmed]
  10. Tenascin knockout mice: barrels, boundary molecules, and glial scars. Steindler, D.A., Settles, D., Erickson, H.P., Laywell, E.D., Yoshiki, A., Faissner, A., Kusakabe, M. J. Neurosci. (1995) [Pubmed]
  11. Neuronal-specific synthesis and glycosylation of tenascin-R. Woodworth, A., Pesheva, P., Fiete, D., Baenziger, J.U. J. Biol. Chem. (2004) [Pubmed]
  12. Enhanced cortical and hippocampal neuronal excitability in mice deficient in the extracellular matrix glycoprotein tenascin-R. Gurevicius, K., Gureviciene, I., Valjakka, A., Schachner, M., Tanila, H. Mol. Cell. Neurosci. (2004) [Pubmed]
  13. Reduced extracellular space in the brain of tenascin-R- and HNK-1-sulphotransferase deficient mice. Syková, E., Vorísek, I., Mazel, T., Antonova, T., Schachner, M. Eur. J. Neurosci. (2005) [Pubmed]
  14. Mice deficient for the extracellular matrix glycoprotein tenascin-r show physiological and structural hallmarks of increased hippocampal excitability, but no increased susceptibility to seizures in the pilocarpine model of epilepsy. Brenneke, F., Bukalo, O., Dityatev, A., Lie, A.A. Neuroscience (2004) [Pubmed]
  15. Tenascin-R interferes with integrin-dependent oligodendrocyte precursor cell adhesion by a ganglioside-mediated signalling mechanism. Probstmeier, R., Michels, M., Franz, T., Chan, B.M., Pesheva, P. Eur. J. Neurosci. (1999) [Pubmed]
  16. Tenascin-R-deficient mice show structural alterations of symmetric perisomatic synapses in the CA1 region of the hippocampus. Nikonenko, A., Schmidt, S., Skibo, G., Brückner, G., Schachner, M. J. Comp. Neurol. (2003) [Pubmed]
  17. Glycosylation of a CNS-specific extracellular matrix glycoprotein, tenascin-R, is dominated by O-linked sialylated glycans and "brain-type" neutral N-glycans. Zamze, S., Harvey, D.J., Pesheva, P., Mattu, T.S., Schachner, M., Dwek, R.A., Wing, D.R. Glycobiology (1999) [Pubmed]
  18. Increased hippocampal and cortical beta oscillations in mice deficient for the HNK-1 sulfotransferase. Gurevicius, K., Gureviciene, I., Sivukhina, E., Irintchev, A., Schachner, M., Tanila, H. Mol. Cell. Neurosci. (2007) [Pubmed]
  19. Morphology of perineuronal nets in tenascin-R and parvalbumin single and double knockout mice. Haunsø, A., Ibrahim, M., Bartsch, U., Letiembre, M., Celio, M.R., Menoud, P. Brain Res. (2000) [Pubmed]
  20. Postnatal development of perineuronal nets in wild-type mice and in a mutant deficient in tenascin-R. Brückner, G., Grosche, J., Schmidt, S., Härtig, W., Margolis, R.U., Delpech, B., Seidenbecher, C.I., Czaniera, R., Schachner, M. J. Comp. Neurol. (2000) [Pubmed]
  21. Tenascin-R (J1 160/180 inhibits fibronectin-mediated cell adhesion--functional relatedness to tenascin-C. Pesheva, P., Probstmeier, R., Skubitz, A.P., McCarthy, J.B., Furcht, L.T., Schachner, M. J. Cell. Sci. (1994) [Pubmed]
  22. Structure of the murine tenascin-R gene and functional characterisation of the promoter. Putthoff, P., Akyüz, N., Kutsche, M., Zardi, L., Borgmeyer, U., Schachner, M. Biochem. Biophys. Res. Commun. (2003) [Pubmed]
  23. Assignment of the tenascin-R gene (Tnr) to mouse chromosome 4 band E2 by fluorescence in situ hybridization; refinement of the human TNR location to chromosome 1q24. Arrigo, G., Gherzi, R., Bonaglia, M.C., Leprini, A., Zuffardi, O., Zardi, L. Cytogenet. Cell Genet. (1997) [Pubmed]
  24. Expression of janusin (J1-160/180) in the retina and optic nerve of the developing and adult mouse. Bartsch, U., Pesheva, P., Raff, M., Schachner, M. Glia (1993) [Pubmed]
  25. Astrocytes and neurons regulate the expression of the neural recognition molecule janusin by cultured oligodendrocytes. Jung, M., Pesheva, P., Schachner, M., Trotter, J. Glia (1993) [Pubmed]
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