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Gene Review

Ptprz1  -  protein tyrosine phosphatase, receptor...

Mus musculus

Synonyms: AI850339, DSD-1-PG, PTPbeta, PTPzeta, Ptprz, ...
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Disease relevance of Ptprz1

  • Taken together, these data indicate that erroneous Ptprz signaling induces gastric ulcers [1].
  • Reverse transcription-polymerase chain reaction analyses indicate that human PTP zeta is highly expressed in a glioblastoma cell line [2].
  • We observed a strong binding of F3IgFc-coated fluorospheres to astrocytes in neural primary cultures and to C6 astrocytoma cells, and demonstrated, in antibody perturbation experiments, that F3-Ig binding on astrocytes depends on its interaction with PTPzeta/RPTPbeta [3].
  • Neonatal dorsal root ganglion (DRG) explants grown on a rich supportive substrate (laminin) with and without DSD-1-PG were strikingly inhibited by the proteoglycan [4].
  • Further characterization of DSD-1-PG has included sequencing of peptides from the core protein and the cloning of the corresponding cDNA using polyclonal antisera against DSD-1-PG to screen phage expression libraries [4].

High impact information on Ptprz1


Chemical compound and disease context of Ptprz1


Biological context of Ptprz1


Anatomical context of Ptprz1


Associations of Ptprz1 with chemical compounds

  • The extracellular portion of human PTP zeta contains two striking structural features: the N-terminal 280-amino acid sequence that is homologous to carbonic anhydrases (carbonate hydro-lyase, EC, and a sequence of 1048 amino acids without a cysteine residue [2].
  • We affinity-isolated tenascin-C and isoforms of the proteoglycan-type protein tyrosine phosphatases zeta/beta (PTPzeta/RPTPbeta) from extracts of developing mouse brain [3].
  • C6 glia-expressed PTPzeta/RPTPbeta stimulated neurite outgrowth by cortical and cerebellar neurons, whereas preclustered F3IgFc specifically modified the distribution of phosphotyrosine labelling in these glial cells [3].
  • The inhibitory effects of DSD-1-PG on the DRG explants were not relieved by removal of the CS GAGs, indicating that this activity is associated with the core glycoprotein [4].
  • DSD-1-PG is a chondroitin sulfate proteoglycan (CSPG) expressed by glial cells that can promote neurite outgrowth from rat embryonic mesencephalic (E14) and hippocampal (E18) neurons, an activity that is associated with the CS glycosaminoglycans (GAGs) [4].

Physical interactions of Ptprz1

  • These observations indicate that TN-R can interact with a phosphacan-related molecule and thereby modulate its inhibitory influence on neuritogenesis [10].
  • These results suggested that Arg78 in midkine plays an essential role in high affinity binding to PTPzeta by interacting with the chondroitin sulfate portion of this receptor [14].
  • Pleiotrophin has been demonstrated to bind to protein-tyrosine phosphatase zeta (PTPzeta) with high affinity [14].

Regulatory relationships of Ptprz1


Other interactions of Ptprz1


Analytical, diagnostic and therapeutic context of Ptprz1


  1. Mice deficient in protein tyrosine phosphatase receptor type Z are resistant to gastric ulcer induction by VacA of Helicobacter pylori. Fujikawa, A., Shirasaka, D., Yamamoto, S., Ota, H., Yahiro, K., Fukada, M., Shintani, T., Wada, A., Aoyama, N., Hirayama, T., Fukamachi, H., Noda, M. Nat. Genet. (2003) [Pubmed]
  2. A human transmembrane protein-tyrosine-phosphatase, PTP zeta, is expressed in brain and has an N-terminal receptor domain homologous to carbonic anhydrases. Krueger, N.X., Saito, H. Proc. Natl. Acad. Sci. U.S.A. (1992) [Pubmed]
  3. The interaction between F3 immunoglobulin domains and protein tyrosine phosphatases zeta/beta triggers bidirectional signalling between neurons and glial cells. Revest, J.M., Faivre-Sarrailh, C., Maeda, N., Noda, M., Schachner, M., Rougon, G. Eur. J. Neurosci. (1999) [Pubmed]
  4. DSD-1-proteoglycan is the mouse homolog of phosphacan and displays opposing effects on neurite outgrowth dependent on neuronal lineage. Garwood, J., Schnädelbach, O., Clement, A., Schütte, K., Bach, A., Faissner, A. J. Neurosci. (1999) [Pubmed]
  5. A critical role for the protein tyrosine phosphatase receptor type Z in functional recovery from demyelinating lesions. Harroch, S., Furtado, G.C., Brueck, W., Rosenbluth, J., Lafaille, J., Chao, M., Buxbaum, J.D., Schlessinger, J. Nat. Genet. (2002) [Pubmed]
  6. The tissue plasminogen activator (tPA)/plasmin extracellular proteolytic system regulates seizure-induced hippocampal mossy fiber outgrowth through a proteoglycan substrate. Wu, Y.P., Siao, C.J., Lu, W., Sung, T.C., Frohman, M.A., Milev, P., Bugge, T.H., Degen, J.L., Levine, J.M., Margolis, R.U., Tsirka, S.E. J. Cell Biol. (2000) [Pubmed]
  7. A receptor-type protein tyrosine phosphatase PTP zeta is expressed in human cutaneous melanomas. Goldmann, T., Otto, F., Vollmer, E. Folia Histochem. Cytobiol. (2000) [Pubmed]
  8. Dynamic spatiotemporal expression patterns of neurocan and phosphacan indicate diverse roles in the developing and adult mouse olfactory system. Clarris, H.J., Rauch, U., Key, B. J. Comp. Neurol. (2000) [Pubmed]
  9. The cloning of a receptor-type protein tyrosine phosphatase expressed in the central nervous system. Levy, J.B., Canoll, P.D., Silvennoinen, O., Barnea, G., Morse, B., Honegger, A.M., Huang, J.T., Cannizzaro, L.A., Park, S.H., Druck, T. J. Biol. Chem. (1993) [Pubmed]
  10. Isolation of a tenascin-R binding protein from mouse brain membranes. A phosphacan-related chondroitin sulfate proteoglycan. Xiao, Z.C., Bartsch, U., Margolis, R.K., Rougon, G., Montag, D., Schachner, M. J. Biol. Chem. (1997) [Pubmed]
  11. Differential upregulation of extracellular matrix molecules associated with the appearance of granule cell dispersion and mossy fiber sprouting during epileptogenesis in a murine model of temporal lobe epilepsy. Heck, N., Garwood, J., Loeffler, J.P., Larmet, Y., Faissner, A. Neuroscience (2004) [Pubmed]
  12. Phosphacan short isoform, a novel non-proteoglycan variant of phosphacan/receptor protein tyrosine phosphatase-beta, interacts with neuronal receptors and promotes neurite outgrowth. Garwood, J., Heck, N., Reichardt, F., Faissner, A. J. Biol. Chem. (2003) [Pubmed]
  13. Neuronal expression of the chondroitin sulfate proteoglycans receptor-type protein-tyrosine phosphatase beta and phosphacan. Hayashi, N., Miyata, S., Yamada, M., Kamei, K., Oohira, A. Neuroscience (2005) [Pubmed]
  14. A receptor-like protein-tyrosine phosphatase PTPzeta/RPTPbeta binds a heparin-binding growth factor midkine. Involvement of arginine 78 of midkine in the high affinity binding to PTPzeta. Maeda, N., Ichihara-Tanaka, K., Kimura, T., Kadomatsu, K., Muramatsu, T., Noda, M. J. Biol. Chem. (1999) [Pubmed]
  15. Neurons as well as astrocytes express proteoglycan-type protein tyrosine phosphatase zeta/RPTPbeta: analysis of mice in which the PTPzeta/RPTPbeta gene was replaced with the LacZ gene. Shintani, T., Watanabe, E., Maeda, N., Noda, M. Neurosci. Lett. (1998) [Pubmed]
  16. Expression of DSD-1-PG in primary neural and glial-derived cell line cultures, upregulation by TGF-beta, and implications for cell-substrate interactions of the glial cell line Oli-neu. Schnädelbach, O., Mandl, C., Faissner, A. Glia (1998) [Pubmed]
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