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Opn1sw  -  opsin 1 (cone pigments), short-wave-sensitive

Rattus norvegicus

Synonyms: BOP, Bcp, Blue cone photoreceptor pigment, Blue-sensitive opsin, S opsin, ...
 
 
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Disease relevance of Opn1sw

 

High impact information on Opn1sw

 

Chemical compound and disease context of Opn1sw

  • We concluded that (a) under the described experimental conditions, dietary fat, fed ad libitum, does not influence the patterns of prostatic cancer induced in rats by BOP; (b) testosterone alters the serum levels of estradiol and luteinizing hormone; and (c) both testosterone and estradiol could be involved in carcinogenesis [2].
  • This study is undertaken in the present work, in which the biodistribution and pharmacokinetics of sulfhydryl boron hydride (BSH) and boronated porphyrin (BOPP) in the RG2 rat glioma model are investigated [9].
  • BHP, MHP, HPOP and NDMM all caused lung carcinomas to develop (22% to 44% incidence), whereas BOP was only associated with adenomas [10].
  • In the present work, the authors demonstrate that the manganese chelate of BOPP also selectively localizes in a rat 9L gliosarcoma and preferentially enhances the tumor-normal brain contrast of T1-weighted images for at least 92 hours [11].
  • The water-soluble free-base derivative, tetrakiscarborane carboxylate ester of 2,4-(alpha,beta-dihydroxyethyl) deuteroporphyrin IX (BOPP), an agent designed for neutron capture therapy, has previously demonstrated selective localization and retention in a C6 murine glioma [11].
 

Biological context of Opn1sw

 

Anatomical context of Opn1sw

  • At doses of 10, 20, and 40 mg BOP/kg, extensive DNA damage was detected in male Syrian golden hamster pancreas but Lewis rat pancreatic DNA was not affected [7].
  • At the same concentration, hamster hepatocyte metabolism of BOP yielded 54.1 TGr mutants and 13.0 Ouar mutants per 10(5) V79 cells [12].
  • HPOP and BHP were detected in the pancreatic juice and bile of both species after administration of BOP and BHP [16].
  • The metabolism of N-nitrosobis(2-oxopropyl)amine (BOP) was examined in microsomes from uninduced F-344 rats [17].
  • TAKA-1, an immortal hamster pancreatic ductal cell line, was treated in vitro for up to 11 weeks with the pancreatic carcinogen N-nitorosobis(2-oxopropyl)amine (BOP) [5].
 

Associations of Opn1sw with chemical compounds

  • N-nitrosobis(2-oxopropyl)amine (BOP), a potent pancreatic carcinogen in hamsters that has failed to induce pancreatic tumors in rats, was studied for its effects on the DNA of both rat and hamster pancreas in order to relate DNA damage (as measured by alkaline elution) to carcinogenicity in vivo [7].
  • The results suggest that pancreatic ductular carcinogenesis in the hamster as a result of exposure to BOP is not due to secretion of carcinogenic metabolities in the pancreatic juice or reflux of bile containing nitrosamine metabolites into the ducts [16].
  • Hamster hepatocytes carried out the catabolism of BOP to CO2 at faster rates than rat hepatocytes; therefore, the species difference in mutagenic activation was not due to a defect in BOP uptake or metabolism by hamster hepatocytes [12].
  • In the 6-thioguanine resistance assay, rat acinar cells induced higher mutation frequencies than hamster acinar cells with both BOP and HPOP [13].
  • Terminal autopsy of rats was 15 months after azaserine treatment and of hamsters 12 months after the last injection with BOP [18].
 

Analytical, diagnostic and therapeutic context of Opn1sw

References

  1. Selective tumor uptake of a boronated porphyrin in an animal model of cerebral glioma. Hill, J.S., Kahl, S.B., Kaye, A.H., Stylli, S.S., Koo, M.S., Gonzales, M.F., Vardaxis, N.J., Johnson, C.I. Proc. Natl. Acad. Sci. U.S.A. (1992) [Pubmed]
  2. Effects of high-fat diet on the patterns of prostatic cancer induced in rats by N-nitrosobis(2-oxopropyl)amine and testosterone. Pour, P.M., Groot, K., Kazakoff, K., Anderson, K., Schally, A.V. Cancer Res. (1991) [Pubmed]
  3. K-ras mutations are frequent in pulmonary squamous cell carcinomas but not in adenocarcinomas of WBN/Kob rats induced by N-nitrosobis(2-oxopropyl)amine. Ohgaki, H., Furukawa, F., Takahashi, M., Kleihues, P. Carcinogenesis (1993) [Pubmed]
  4. Modulation of dietary fat-promoted pancreatic carcinogenesis in rats and hamsters by chronic coffee ingestion. Woutersen, R.A., van Garderen-Hoetmer, A., Bax, J., Scherer, E. Carcinogenesis (1989) [Pubmed]
  5. In vitro pancreatic ductal cell carcinogenesis. Ikematsu, Y., Liu, G., Fienhold, M.A., Cano, M., Adrian, T.E., Hollingsworth, M.A., Williamson, J.E., Sanger, W., Tomioka, T., Pour, P.M. Int. J. Cancer (1997) [Pubmed]
  6. Cellular toxicity of pancreatic carcinogens. Zucker, P.F., Chan, A.M., Archer, M.C. J. Natl. Cancer Inst. (1986) [Pubmed]
  7. Positive correlation between pancreatic DNA damage and species specificity in response to N-nitrosobis(2-oxopropyl)amine. Zurlo, J., Longnecker, D.S. J. Natl. Cancer Inst. (1983) [Pubmed]
  8. Regulation of gene expression in the mammalian eye and its relevance to eye disease. Scheetz, T.E., Kim, K.Y., Swiderski, R.E., Philp, A.R., Braun, T.A., Knudtson, K.L., Dorrance, A.M., Dibona, G.F., Huang, J., Casavant, T.L., Sheffield, V.C., Stone, E.M. Proc. Natl. Acad. Sci. U.S.A. (2006) [Pubmed]
  9. A comparative study on the pharmacokinetics and biodistribution of boronated porphyrin (BOPP) and sulfhydryl boron hydride (BSH) in the RG2 rat glioma model. Ceberg, C.P., Brun, A., Kahl, S.B., Koo, M.S., Persson, B.R., Salford, L.G. J. Neurosurg. (1995) [Pubmed]
  10. Carcinogenic potency of N-nitrosomethyl(2-hydroxypropyl)amine and other metabolic relatives of N-nitrosobis(2-hydroxypropyl)amine by single intraperitoneal injection on the lung of rats. Yokose, Y., Yamamoto, K., Nakajima, A., Eimoto, H., Maruyama, H., Mori, Y., Konishi, Y. Jpn. J. Cancer Res. (1988) [Pubmed]
  11. Boronated metalloporphyrins: a novel approach to the diagnosis and treatment of cancer using contrast-enhanced MR imaging and neutron capture therapy. Huang, L.R., Straubinger, R.M., Kahl, S.B., Koo, M.S., Alletto, J.J., Mazurchuk, R., Chau, R.I., Thamer, S.L., Fiel, R.J. Journal of magnetic resonance imaging : JMRI. (1993) [Pubmed]
  12. Species specificity in the metabolism of N-nitrosobis(2-oxopropyl)amine and N-nitroso(2-hydroxypropyl)(2-oxopropyl)amine to mutagens by isolated rat and hamster hepatocytes. Mangino, M.M., Hollenberg, P.F., Scarpelli, D.G. Cancer Res. (1987) [Pubmed]
  13. Activation of N-nitrosobis(2-oxopropyl)amine and N-nitroso(2-hydroxypropyl)-(2-oxopropyl)amine to mutagens for V79 cells by isolated hamster and rat pancreatic acinar cells. Mangino, M.M., Scarpelli, D.G., Hollenberg, P.F. Cancer Res. (1985) [Pubmed]
  14. Alkylation of rodent tissue DNA induced by N-nitrosobis(2-hydroxypropyl)amine. Kokkinakis, D.M. Carcinogenesis (1992) [Pubmed]
  15. Cell specific DNA alkylation in target and non-target organs of N-nitrosobis(2-oxopropyl)amine-induced carcinogenesis in hamster and rat. Bax, J., Schippers-Gillissen, C., Woutersen, R.A., Scherer, E. Carcinogenesis (1991) [Pubmed]
  16. Metabolism of three radiolabeled pancreatic carcinogenic nitrosamines in hamsters and rats. Gingell, R., Brunk, G., Nagel, D., Pour, P. Cancer Res. (1979) [Pubmed]
  17. The metabolism of N-nitrosobis(2-oxopropyl)amine by microsomes and hepatocytes from Fischer 344 rats. Farrelly, J.G., Saavedra, J.E., Kupper, R.J., Stewart, M.L. Carcinogenesis (1987) [Pubmed]
  18. Modulation of dietary fat-promoted pancreatic carcinogenesis in rats and hamsters by chronic ethanol ingestion. Woutersen, R.A., van Garderen-Hoetmer, A., Bax, J., Scherer, E. Carcinogenesis (1989) [Pubmed]
  19. The role of testosterone in the nasal cavity tumors induced by N-nitrosobis(2-oxopropyl)amine in rats. Pour, P.M., Stepan, K.R. Carcinogenesis (1988) [Pubmed]
  20. Toxicity, biodistribution, and convection-enhanced delivery of the boronated porphyrin BOPP in the 9L intracerebral rat glioma model. Ozawa, T., Afzal, J., Lamborn, K.R., Bollen, A.W., Bauer, W.F., Koo, M.S., Kahl, S.B., Deen, D.F. Int. J. Radiat. Oncol. Biol. Phys. (2005) [Pubmed]
  21. Involvement of cytochrome P450 2E1-like isoform in the activation of N-nitrosobis(2-oxopropyl)amine in the rat nasal mucosa. Kazakoff, K., Iversen, P., Lawson, T., Baron, J., Guengerich, F.P., Pour, P.M. Eur. J. Cancer, B, Oral Oncol. (1994) [Pubmed]
  22. Induction of thyroid follicular adenomas and carcinomas by N-nitrosobis(2-oxopropyl)amine. Pour, P., Salmasizadeh, S. Cancer Lett. (1978) [Pubmed]
 
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