Disease relevance of OPN1SW

• When fed after BOP treatment, HP diet inhibited, among induced tumors, pulmonary adenomas in males [1].
• Related CBT for hemoglobinopathies offers a good probability of success and is associated with a low risk of GVHD [2].
• The overall data confirm the inhibitory effect of SZ on BOP-induced pancreatic cancer and suggest that this effect is related to the diabetic condition of hamsters rather than insulin deficiency and that intact islets appear to be prerequisite for exocrine pancreatic cancer induction by BOP [3].
• SZ pretreatment inhibited the incidence of BOP-induced pancreatic ductal/ductular cell carcinomas in the SZ + BOP group (P less than 0.01); this protective effect of SZ on carcinoma development was potentiated by additional treatment with insulin (SZ + insulin + BOP group, P less than 0.001) [3].
• On the other hand, the inhibitory action of insulin on insuloma induction by SZ and on ductal/ductular cancer induction by BOP seems to be related to the suppressive effect of this hormone on beta-cell and ductal/ductular cell replication, respectively [3].

Psychiatry related information on OPN1SW

• Several controlled and open studies of traumatized children with chronic posttraumatic stress disorder have provided additional support for TF-CBT interventions; however, the optimal dosage and critical components of TF-CBT for traumatized children have not been determined [4].
• Future approaches to treating panic disorder in primary care would be enhanced by including assessments of patient beliefs and preferences, spending more time in preparing the patient for treatment, utilizing a simple pharmacotherapy algorithm, utilizing simple rating scales to monitor outcomes, and training providers in brief CBT interventions [5].
• Those with a commitment to research would benefit from subscribing to the journal Cognitive Therapy and Research. CBT does not aim to be a panacea for every disorder, and cognitive therapists are critical of its overzealous use by inadequately trained or poorly informed therapists [6].
• While the CBT group showed a reduction in depressive symptoms, the same symptoms increased in the Standard group [7].
• OBJECTIVE: This study compared family-focused cognitive behavioral therapy (CBT; the Building Confidence Program) with traditional child-focused CBT with minimal family involvement for children with anxiety disorders [8].

High impact information on OPN1SW

• N-Nitrosobis(2-oxopropyl)amine (BOP; CAS; 60599-38-4) treatment was given as a single sc injection of 20 mg/kg (body wt) at 8 weeks of age, and surviving hamsters were killed 50 weeks later [9].
• BOP treatment depressed plasma GSHPX at 24 hours and elevated erythrocyte and liver values at 4 weeks [9].
• Human tritanopia associated with two amino acid substitutions in the blue-sensitive opsin [10].
• We have used PCR, denaturing gradient gel electrophoresis, and DNA sequencing of amplified exons to detect in four of nine unrelated tritanopic subjects two different point mutations in the gene encoding the blue-sensitive opsin, each leading to an amino acid substitution [10].
• AML samples were significantly more sensitive to tipifarnib compared to B-cell precursor ALL (BCP ALL) or N BM samples [11].

Chemical compound and disease context of OPN1SW

• Pancreatic ductular adenoma yields were highest in all male groups given diets of 0.1 ppm Se before BOP administration, irrespective of the Se level after BOP was fed [9].
• However, in CBT, a human brain tumor cell line, we find that N6,O2'-dibutyryl cyclic adenosine 3':5'-monophosphate, but not butyrate, stimulated ectopic production of the beta subunit of chorionic gonadotropin [12].
• The nontrophoblastic brain tumor line CBT was an exception to this general rule in that HCG-beta production was stimulated by dibutyryl cyclic AMP but not by butyrate [13].
• Ductal pancreatic cancers were induced with N-nitrosobis(2-oxopropyl)amine (BOP) in female Syrian golden hamsters [14].
• The incidence of pancreatic adenocarcinomas was significantly (p < 0.05) decreased in the BOP/400 ppm nimesulide group compared to the BOP alone group [15].

Biological context of OPN1SW

• This is consistent with previous mapping of the BCP gene to chromosome 7q31-35 [16].
• In this study, the BCP gene has been localised to chromosome 7q31.3-32 by fluorescent in situ hybridisation of cosmid clones containing the gene [16].
• Single nucleotide polymorphism in exon 2 of the BCP gene on 7q31-q35 [17].
• We have recently demonstrated that the rate of cell division of BCP ALL cells increases when cultured in direct contact with BM stromal cells [18].
• Psychiatric pharmacists have expertise in psychopharmacology, and more than 50 percent have achieved board certification in psychiatric pharmacy (BCPP) [19].

Anatomical context of OPN1SW

• Blue cone pigment (BCP) is one of three types of cone photoreceptors responsible for normal colour vision [16].
• T-cell ALL samples were significantly more sensitive than BCP ALL and N BM samples [11].
• The effects of streptozotocin (SZ) and N-nitrosobis(2-oxopropyl)amine (BOP), separately or in combination, on the pancreas, common duct, and gallbladder, all target tissues of BOP, were studied in Syrian golden hamsters [3].
• Measurement of these hormones revealed a significant decrease in plasma Ins during early stages of carcinogenesis with concomitant increase of Ins level in pancreatic juice at 12 weeks after 6 weekly BOP treatments [20].
• Hamsters in the SZ, SZ + BOP, and SZ + insulin + BOP groups developed islet cell adenomas (insulomas) [3].

Associations of OPN1SW with chemical compounds

• All patients were treated initially with BCNU, cyclophosphamide, and prednisone (BCP) until a designated level of response was achieved [21].
• Responders were randomly assigned to either melphalan and prednisone (MP); prednisone, Adriamycin (Adria Laboratories, Columbus, Ohio), azathioprine, and vincristine (PAIV), or no therapy until relapse, then treatment with BCP [21].
• The conditioning regimen was cyclophosphamide (6,000 mg/m2), carmustine (BCNU; 450 mg/m2), and thiotepa (720 mg/m2) (CBT regimen) [22].
• The role of protein kinases in BCP crystal-stimulated DNA synthesis was investigated using thymidine incorporation, kinase inhibitors, and protein kinase C (PKC) assays [23].
• A novel class of O6-(benzotriazol-1-yl)inosine as well as the corresponding 2'-deoxy derivatives can be conveniently prepared by a reaction between sugar-protected or -unprotected inosine or 2'-deoxyinosine nucleosides and 1H-benzotriazol-1-yloxy-tris(dimethylamino)phosphonium hexafluorophosphate (BOP) [24].

Physical interactions of OPN1SW

• The complexes are applied as emitting guests in LED devices of the structure ITO/HTL(BPAPF or NPB)/6% Ir in CBP/BCP/Alq(3)/LiF/Al [25].

Analytical, diagnostic and therapeutic context of OPN1SW

• The control group consisted of hamsters treated with a single dose of BOP and daily doses of insulin (insulin + BOP group) [3].
• BACKGROUND: To investigate immune reactions after reduced-intensity cord-blood transplantation (RI-CBT) [26].
• In all cases, aggregates between BCP ALL and BM stromal cells were identified by flow cytometry and isolated [18].
• Meta-analysis of CBT for depression in adolescents [27].
• This represents the first treatment outcome study of CBT for psychosis with a manualized, active comparison condition [28].

References