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OPN1SW  -  opsin 1 (cone pigments), short-wave-sensitive

Homo sapiens

Synonyms: BCP, BOP, Blue cone photoreceptor pigment, Blue-sensitive opsin, CBT, ...
 
 
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Disease relevance of OPN1SW

  • When fed after BOP treatment, HP diet inhibited, among induced tumors, pulmonary adenomas in males [1].
  • Related CBT for hemoglobinopathies offers a good probability of success and is associated with a low risk of GVHD [2].
  • The overall data confirm the inhibitory effect of SZ on BOP-induced pancreatic cancer and suggest that this effect is related to the diabetic condition of hamsters rather than insulin deficiency and that intact islets appear to be prerequisite for exocrine pancreatic cancer induction by BOP [3].
  • SZ pretreatment inhibited the incidence of BOP-induced pancreatic ductal/ductular cell carcinomas in the SZ + BOP group (P less than 0.01); this protective effect of SZ on carcinoma development was potentiated by additional treatment with insulin (SZ + insulin + BOP group, P less than 0.001) [3].
  • On the other hand, the inhibitory action of insulin on insuloma induction by SZ and on ductal/ductular cancer induction by BOP seems to be related to the suppressive effect of this hormone on beta-cell and ductal/ductular cell replication, respectively [3].
 

Psychiatry related information on OPN1SW

  • Several controlled and open studies of traumatized children with chronic posttraumatic stress disorder have provided additional support for TF-CBT interventions; however, the optimal dosage and critical components of TF-CBT for traumatized children have not been determined [4].
  • Future approaches to treating panic disorder in primary care would be enhanced by including assessments of patient beliefs and preferences, spending more time in preparing the patient for treatment, utilizing a simple pharmacotherapy algorithm, utilizing simple rating scales to monitor outcomes, and training providers in brief CBT interventions [5].
  • Those with a commitment to research would benefit from subscribing to the journal Cognitive Therapy and Research. CBT does not aim to be a panacea for every disorder, and cognitive therapists are critical of its overzealous use by inadequately trained or poorly informed therapists [6].
  • While the CBT group showed a reduction in depressive symptoms, the same symptoms increased in the Standard group [7].
  • OBJECTIVE: This study compared family-focused cognitive behavioral therapy (CBT; the Building Confidence Program) with traditional child-focused CBT with minimal family involvement for children with anxiety disorders [8].
 

High impact information on OPN1SW

 

Chemical compound and disease context of OPN1SW

 

Biological context of OPN1SW

 

Anatomical context of OPN1SW

 

Associations of OPN1SW with chemical compounds

  • All patients were treated initially with BCNU, cyclophosphamide, and prednisone (BCP) until a designated level of response was achieved [21].
  • Responders were randomly assigned to either melphalan and prednisone (MP); prednisone, Adriamycin (Adria Laboratories, Columbus, Ohio), azathioprine, and vincristine (PAIV), or no therapy until relapse, then treatment with BCP [21].
  • The conditioning regimen was cyclophosphamide (6,000 mg/m2), carmustine (BCNU; 450 mg/m2), and thiotepa (720 mg/m2) (CBT regimen) [22].
  • The role of protein kinases in BCP crystal-stimulated DNA synthesis was investigated using thymidine incorporation, kinase inhibitors, and protein kinase C (PKC) assays [23].
  • A novel class of O6-(benzotriazol-1-yl)inosine as well as the corresponding 2'-deoxy derivatives can be conveniently prepared by a reaction between sugar-protected or -unprotected inosine or 2'-deoxyinosine nucleosides and 1H-benzotriazol-1-yloxy-tris(dimethylamino)phosphonium hexafluorophosphate (BOP) [24].
 

Physical interactions of OPN1SW

  • The complexes are applied as emitting guests in LED devices of the structure ITO/HTL(BPAPF or NPB)/6% Ir in CBP/BCP/Alq(3)/LiF/Al [25].
 

Analytical, diagnostic and therapeutic context of OPN1SW

References

  1. Effect of dietary protein on N-nitrosobis(2-oxopropyl)amine-induced carcinogenesis and on spontaneous diseases in Syrian golden hamsters. Pour, P.M., Birt, D.F. J. Natl. Cancer Inst. (1986) [Pubmed]
  2. Related umbilical cord blood transplantation in patients with thalassemia and sickle cell disease. Locatelli, F., Rocha, V., Reed, W., Bernaudin, F., Ertem, M., Grafakos, S., Brichard, B., Li, X., Nagler, A., Giorgiani, G., Haut, P.R., Brochstein, J.A., Nugent, D.J., Blatt, J., Woodard, P., Kurtzberg, J., Rubin, C.M., Miniero, R., Lutz, P., Raja, T., Roberts, I., Will, A.M., Yaniv, I., Vermylen, C., Tannoia, N., Garnier, F., Ionescu, I., Walters, M.C., Lubin, B.H., Gluckman, E. Blood (2003) [Pubmed]
  3. Inhibition of streptozotocin-induced islet cell tumors and N-nitrosobis(2-oxopropyl)amine-induced pancreatic exocrine tumors in Syrian hamsters by exogenous insulin. Pour, P.M., Kazakoff, K., Carlson, K. Cancer Res. (1990) [Pubmed]
  4. Treating acute posttraumatic reactions in children and adolescents. Cohen, J.A. Biol. Psychiatry (2003) [Pubmed]
  5. Understanding and treating panic disorder in the primary care setting. Roy-Byrne, P.P., Wagner, A.W., Schraufnagel, T.J. The Journal of clinical psychiatry. (2005) [Pubmed]
  6. Cognitive therapy. Scott, J. The British journal of psychiatry : the journal of mental science. (1994) [Pubmed]
  7. A blind, randomized, controlled trial of cognitive-behavioural intervention for patients with recent onset rheumatoid arthritis: preventing psychological and physical morbidity. Sharpe, L., Sensky, T., Timberlake, N., Ryan, B., Brewin, C.R., Allard, S. Pain (2001) [Pubmed]
  8. Family cognitive behavioral therapy for child anxiety disorders. Wood, J.J., Piacentini, J.C., Southam-Gerow, M., Chu, B.C., Sigman, M. Journal of the American Academy of Child and Adolescent Psychiatry. (2006) [Pubmed]
  9. Effects of dietary selenium on bis(2-oxopropyl)nitrosamine-induced carcinogenesis in Syrian golden hamsters. Birt, D.F., Julius, A.D., Runice, C.E., Salmasi, S. J. Natl. Cancer Inst. (1986) [Pubmed]
  10. Human tritanopia associated with two amino acid substitutions in the blue-sensitive opsin. Weitz, C.J., Miyake, Y., Shinzato, K., Montag, E., Zrenner, E., Went, L.N., Nathans, J. Am. J. Hum. Genet. (1992) [Pubmed]
  11. In vitro profiling of the sensitivity of pediatric leukemia cells to tipifarnib: identification of T-cell ALL and FAB M5 AML as the most sensitive subsets. Goemans, B.F., Zwaan, C.M., Harlow, A., Loonen, A.H., Gibson, B.E., Hählen, K., Reinhardt, D., Creutzig, U., Heinrich, M.C., Kaspers, G.J. Blood (2005) [Pubmed]
  12. Stimulation of N6,O2'-dibutyryl cyclic adenosine 3':5'-monophosphate of ectopic production of the free beta subunit of chorionic gonadotropin by a human brain tumor cell line. Rosen, S.W., Calvert, I., Weintraub, B.D., Tseng, J.S., Rabson, A.S. Cancer Res. (1980) [Pubmed]
  13. Stimulation of synthesis and secretion of chorionic gonadotropin subunits by eutopic and ectopic hormone-producing human cell lines. Ruddon, R.W., Anderson, C., Meade-Cobun, K.S. Cancer Res. (1980) [Pubmed]
  14. Effect of combination treatment with analogs of luteinizing hormone-releasing hormone (LH-RH) or somatostatin and 5-fluorouracil on pancreatic cancer in hamsters. Szepeshazi, K., Lapis, K., Schally, A.V. Int. J. Cancer (1991) [Pubmed]
  15. A cyclooxygenase-2 inhibitor, nimesulide, inhibits postinitiation phase of N-nitrosobis(2-oxopropyl)amine-induced pancreatic carcinogenesis in hamsters. Furukawa, F., Nishikawa, A., Lee, I.S., Kanki, K., Umemura, T., Okazaki, K., Kawamori, T., Wakabayashi, K., Hirose, M. Int. J. Cancer (2003) [Pubmed]
  16. Localisation of the human blue cone pigment gene to chromosome band 7q31.3-32. Fitzgibbon, J., Appukuttan, B., Gayther, S., Wells, D., Delhanty, J., Hunt, D.M. Hum. Genet. (1994) [Pubmed]
  17. Single nucleotide polymorphism in exon 2 of the BCP gene on 7q31-q35. Jordan, S.A., Humphries, P. Hum. Mol. Genet. (1994) [Pubmed]
  18. Flow cytometric analysis of intercellular adhesion between B-cell precursor acute lymphoblastic leukemic cells and bone marrow stromal cells. Ashley, D.M., Bol, S.J., Tucker, D.P., Waugh, C.M., Kannourakis, G. Leukemia (1995) [Pubmed]
  19. Developing a partnership with NAMI and psychiatric pharmacists. Roe, K.K., Dopheide, J.A., Wincor, M.Z. Schizophrenia bulletin. (2002) [Pubmed]
  20. Alteration of pancreatic endocrine cell patterns and their secretion during pancreatic carcinogenesis in the hamster model. Pour, P.M., Bell, R.H. Cancer Res. (1989) [Pubmed]
  21. Consolidation and maintenance therapy in multiple myeloma: randomized comparison of a new approach to therapy after initial response to treatment. Cohen, H.J., Bartolucci, A.A., Forman, W.B., Silberman, H.R. J. Clin. Oncol. (1986) [Pubmed]
  22. Allogeneic peripheral-blood progenitor-cell transplantation for poor-risk patients with metastatic breast cancer. Ueno, N.T., Rondón, G., Mirza, N.Q., Geisler, D.K., Anderlini, P., Giralt, S.A., Andersson, B.S., Claxton, D.F., Gajewski, J.L., Khouri, I.F., Körbling, M., Mehra, R.C., Przepiorka, D., Rahman, Z., Samuels, B.I., van Besien, K., Hortobagyi, G.N., Champlin, R.E. J. Clin. Oncol. (1998) [Pubmed]
  23. Basic calcium phosphate crystals stimulate cell proliferation and collagenase message accumulation in cultured adult articular chondrocytes. Mitchell, P.G., Struve, J.A., McCarthy, G.M., Cheung, H.S. Arthritis Rheum. (1992) [Pubmed]
  24. O6-(benzotriazol-1-yl)inosine derivatives: easily synthesized, reactive nucleosides. Bae, S., Lakshman, M.K. J. Am. Chem. Soc. (2007) [Pubmed]
  25. Efficient red-emitting cyclometalated Iridium(III) complexes containing lepidine-based ligands. Thomas, K.R., Velusamy, M., Lin, J.T., Chien, C.H., Tao, Y.T., Wen, Y.S., Hu, Y.H., Chou, P.T. Inorganic chemistry. (2005) [Pubmed]
  26. Early immune reaction after reduced-intensity cord-blood transplantation for adult patients. Kishi, Y., Kami, M., Miyakoshi, S., Kanda, Y., Murashige, N., Teshima, T., Kusumi, E., Hara, S., Matsumura, T., Yuji, K., Masuoka, K., Wake, A., Morinaga, S., Kanemaru, M., Hayashi, T., Tanaka, Y., Taniguchi, S. Transplantation (2005) [Pubmed]
  27. Meta-analysis of CBT for depression in adolescents. Harrington, R., Campbell, F., Shoebridge, P., Whittaker, J. Journal of the American Academy of Child and Adolescent Psychiatry. (1998) [Pubmed]
  28. A pilot study of functional Cognitive Behavioral Therapy (fCBT) for schizophrenia. Cather, C., Penn, D., Otto, M.W., Yovel, I., Mueser, K.T., Goff, D.C. Schizophr. Res. (2005) [Pubmed]
 
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