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Chemical Compound Review

CCRIS 460     N,N-bis(2-oxopropyl)nitrous amide

Synonyms: CHEMBL164394, AG-G-18157, LS-7590, CTK5B1794, ZINC05196582, ...
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Disease relevance of CCRIS 460


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Chemical compound and disease context of CCRIS 460


Biological context of CCRIS 460


Anatomical context of CCRIS 460


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Gene context of CCRIS 460


Analytical, diagnostic and therapeutic context of CCRIS 460


  1. Modifying factors in pancreatic carcinogenesis in the hamster model. IV. Effects of dietary protein. Pour, P.M., Birt, D.F. J. Natl. Cancer Inst. (1983) [Pubmed]
  2. Fibrin deposition in autochthonous Syrian hamster pancreatic adenocarcinomas induced by the chemical carcinogen N-nitroso-bis(2-oxopropyl)amine. Brown, L.F., Chester, J.F., Malt, R.A., Dvorak, H.F. J. Natl. Cancer Inst. (1987) [Pubmed]
  3. Modification of pancreatic carcinogenesis in the hamster model. XI. Inhibitory effect of pilocarpine hydrochloride. Pour, P.M., Lawson, T., Donnelly, T., Stepan, K. J. Natl. Cancer Inst. (1984) [Pubmed]
  4. Modification of pancreatic carcinogenesis in the hamster model. IX. Effect of pancreatitis. Pour, P.M., Takahashi, M., Donnelly, T., Stepan, K. J. Natl. Cancer Inst. (1983) [Pubmed]
  5. Genomic p53 mutation in a chemically induced hamster pancreatic ductal adenocarcinoma. Chang, K.W., Mangold, K.A., Hubchak, S., Laconi, S., Scarpelli, D.G. Cancer Res. (1994) [Pubmed]
  6. Effects of dietary selenium on bis(2-oxopropyl)nitrosamine-induced carcinogenesis in Syrian golden hamsters. Birt, D.F., Julius, A.D., Runice, C.E., Salmasi, S. J. Natl. Cancer Inst. (1986) [Pubmed]
  7. Cellular toxicity of pancreatic carcinogens. Zucker, P.F., Chan, A.M., Archer, M.C. J. Natl. Cancer Inst. (1986) [Pubmed]
  8. Effects of the interaction of dietary fat and protein on N-nitrosobis(2-oxopropyl)amine-induced carcinogenesis and spontaneous lesions in Syrian golden hamsters. Birt, D.F., Pour, P.M. J. Natl. Cancer Inst. (1985) [Pubmed]
  9. Positive correlation between pancreatic DNA damage and species specificity in response to N-nitrosobis(2-oxopropyl)amine. Zurlo, J., Longnecker, D.S. J. Natl. Cancer Inst. (1983) [Pubmed]
  10. Prevention of N-nitrosobis(2-oxopropyl)amine-induced nasal cavity tumors in rats by orchiectomy. Pour, P.M., Götz, U. J. Natl. Cancer Inst. (1983) [Pubmed]
  11. Effects of high-fat diet on the patterns of prostatic cancer induced in rats by N-nitrosobis(2-oxopropyl)amine and testosterone. Pour, P.M., Groot, K., Kazakoff, K., Anderson, K., Schally, A.V. Cancer Res. (1991) [Pubmed]
  12. Treatment of N-nitrosobis(2-oxopropyl)amine-induced pancreatic cancer in Syrian golden hamsters with D-Trp-6-LH-RH and somatostatin analogue RC-160 microcapsules. Zalatnai, A., Schally, A.V. Cancer Res. (1989) [Pubmed]
  13. Importance of diabetes in inhibition of pancreatic cancer by streptozotocin. Bell, R.H., Sayers, H.J., Pour, P.M., Ray, M.B., McCullough, P.J. J. Surg. Res. (1989) [Pubmed]
  14. Effect of dibutyltin dichloride on incidence of pancreatic adenocarcinoma induced in hamsters by a single dose of N-nitrosobis(2-oxopropyl)amine. Takahashi, M., Furukawa, F., Kokubo, T., Kurata, Y., Hayashi, Y. Cancer Lett. (1983) [Pubmed]
  15. Protective effects of benzyl isothiocyanate and sulforaphane but not resveratrol against initiation of pancreatic carcinogenesis in hamsters. Kuroiwa, Y., Nishikawa, A., Kitamura, Y., Kanki, K., Ishii, Y., Umemura, T., Hirose, M. Cancer Lett. (2006) [Pubmed]
  16. Transplacental induction of gonadal tumors in rats by a nitrosamine. Pour, P.M. Cancer Res. (1986) [Pubmed]
  17. Augmentation of carcinogenesis by N-nitrosobis(2-oxopropyl)amine administered during S phase of the cell cycle in regenerating hamster pancreas. Scarpelli, D.G., Rao, M.S., Subbarao, V. Cancer Res. (1983) [Pubmed]
  18. Regression of nitrosamine-induced pancreatic cancers in hamsters treated with luteinizing hormone-releasing hormone antagonists or agonists. Szende, B., Srkalovic, G., Groot, K., Lapis, K., Schally, A.V. Cancer Res. (1990) [Pubmed]
  19. 5-Lipoxygenase, a marker for early pancreatic intraepithelial neoplastic lesions. Hennig, R., Grippo, P., Ding, X.Z., Rao, S.M., Buchler, M.W., Friess, H., Talamonti, M.S., Bell, R.H., Adrian, T.E. Cancer Res. (2005) [Pubmed]
  20. Cell specific DNA alkylation in target and non-target organs of N-nitrosobis(2-oxopropyl)amine-induced carcinogenesis in hamster and rat. Bax, J., Schippers-Gillissen, C., Woutersen, R.A., Scherer, E. Carcinogenesis (1991) [Pubmed]
  21. Increased tumorigenesis induced by N-nitrosobis(2-oxopropyl)amine in Syrian golden hamsters fed high-fat diets. Birt, D.F., Pour, P.M. J. Natl. Cancer Inst. (1983) [Pubmed]
  22. Species specificity in the metabolism of N-nitrosobis(2-oxopropyl)amine and N-nitroso(2-hydroxypropyl)(2-oxopropyl)amine to mutagens by isolated rat and hamster hepatocytes. Mangino, M.M., Hollenberg, P.F., Scarpelli, D.G. Cancer Res. (1987) [Pubmed]
  23. Metabolism of pancreatic carcinogens N-nitroso-2,6-dimethylmorpholine and N-nitrosobis(2-oxopropyl)amine by microsomes and cytosol of hamster pancreas and liver. Kokkinakis, D.M., Scarpelli, D.G., Rao, M.S., Hollenberg, P.F. Cancer Res. (1983) [Pubmed]
  24. Induction of exocrine pancreatic, bile duct, and thyroid gland tumors in offspring of Syrian hamsters treated with N-nitrosobis(2-oxopropyl)amine during pregnancy. Pour, P.M. Cancer Res. (1986) [Pubmed]
  25. Inhibitory effect of bombesin/gastrin-releasing peptide antagonist RC-3095 and high dose of somatostatin analogue RC-160 on nitrosamine-induced pancreatic cancers in hamsters. Szepeshazi, K., Schally, A.V., Cai, R.Z., Radulovic, S., Milovanovic, S., Szoke, B. Cancer Res. (1991) [Pubmed]
  26. Modification of pancreatic carcinogenesis in the hamster model. XII. Dose-related effect of ethanol. Pour, P.M., Reber, H.A., Stepan, K. J. Natl. Cancer Inst. (1983) [Pubmed]
  27. Effects of dietary linoleic acid on pancreatic carcinogenesis in rats and hamsters. Appel, M.J., van Garderen-Hoetmer, A., Woutersen, R.A. Cancer Res. (1994) [Pubmed]
  28. Chemopreventive activity of Oltipraz against N-nitrosobis(2-oxopropyl)amine (BOP)-induced ductal pancreatic carcinoma development and effects on survival of Syrian golden hamsters. Clapper, M.L., Wood, M., Leahy, K., Lang, D., Miknyoczki, S., Ruggeri, B.A. Carcinogenesis (1995) [Pubmed]
  29. The role of testosterone in the nasal cavity tumors induced by N-nitrosobis(2-oxopropyl)amine in rats. Pour, P.M., Stepan, K.R. Carcinogenesis (1988) [Pubmed]
  30. Mutagenicity in V79 cells of N-nitrosobis(2-hydroxypropyl)amine and N-nitrosobis(2-oxopropyl)amine activated by tissues from hamsters fed low and high fat diets. Lawson, T. Carcinogenesis (1992) [Pubmed]
  31. Expression of matrix metalloproteinase 2 (MMP-2), membrane-type 1 MMP and tissue inhibitor of metalloproteinase 2 and activation of proMMP-2 in pancreatic duct adenocarcinomas in hamsters treated with N-nitrosobis(2-oxopropyl)amine. Iki, K., Tsutsumi, M., Kido, A., Sakitani, H., Takahama, M., Yoshimoto, M., Motoyama, M., Tatsumi, K., Tsunoda, T., Konishi, Y. Carcinogenesis (1999) [Pubmed]
  32. Activation of c-K-ras is frequent in pancreatic carcinomas of Syrian hamsters, but is absent in pancreatic tumors of rats. van Kranen, H.J., Vermeulen, E., Schoren, L., Bax, J., Woutersen, R.A., van Iersel, P., van Kreijl, C.F., Scherer, E. Carcinogenesis (1991) [Pubmed]
  33. A cyclooxygenase-2 inhibitor, nimesulide, inhibits postinitiation phase of N-nitrosobis(2-oxopropyl)amine-induced pancreatic carcinogenesis in hamsters. Furukawa, F., Nishikawa, A., Lee, I.S., Kanki, K., Umemura, T., Okazaki, K., Kawamori, T., Wakabayashi, K., Hirose, M. Int. J. Cancer (2003) [Pubmed]
  34. Effects of sandostatin and castration on pancreatic carcinogenesis in rats and hamsters. Meijers, M., Woutersen, R.A., van Garderen-Hoetmer, A., Bakker, G.H., de Jong, F.H., Foekens, J.A., Klijn, J.G. Int. J. Cancer (1992) [Pubmed]
  35. Effects of high-fat diet and cholecystokinin receptor blockade on promotion of pancreatic ductal cell tumors in the hamster. Herrington, M.K., Gasslander, T., Cina, R.A., Fehsenfeld, D.M., Kazakoff, K.R., Pour, P.M., Adrian, T.E. Nutrition and cancer. (1997) [Pubmed]
  36. Modifying factors in pancreatic carcinogenesis in the hamster model. I. Effect of protein-free diet fed during the early stages of carcinogenesis. Pour, P.M., Birt, D.F., Salmasi, S.Z., Götz, U. J. Natl. Cancer Inst. (1983) [Pubmed]
  37. Modification of pancreatic carcinogenesis in the hamster model. 6. The effect of ductal ligation and excision. Pour, P.M., Donnelly, T., Stepan, K. Am. J. Pathol. (1983) [Pubmed]
  38. Effects of aminoglutethimide, alone and in combination with surgical castration, on pancreatic carcinogenesis in rats and hamsters. Visser, C.J., Meijers, M., van Garderen-Hoetmer, A., Klijn, J.G., Foekens, J.A., Woutersen, R.A. Int. J. Cancer (1995) [Pubmed]
  39. Promoting effect of truncal vagotomy on pancreatic carcinogenesis initiated with N-nitrosobis(2-oxopropyl)amine in Syrian golden hamsters. Ogawa, T., Makino, T., Mizumoto, K., Nakayama, F. Carcinogenesis (1991) [Pubmed]
  40. Chemoprevention of biliary carcinogenesis in syrian hamsters by the novel carboxamide derivative IS-741 after initiation with N-nitrosobis(2-oxopropyl)amine (BOP). Ogura, Y., Matsuda, S., Ito, M., Niimi, R., Sumitomo, M., Kawarada, Y. Carcinogenesis (2000) [Pubmed]
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