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Gene Review

Bmx  -  BMX non-receptor tyrosine kinase

Mus musculus

Synonyms: Bone marrow tyrosine kinase gene in chromosome X protein homolog, Cytoplasmic tyrosine-protein kinase BMX, Etk, Etk/Bmx, Tyro8
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Disease relevance of Bmx


High impact information on Bmx


Biological context of Bmx

  • In this study, mice were generated in which the first coding exon of the Bmx gene was replaced with the lacZ reporter gene by a knock-in strategy [7].
  • The homozygous mice lacking Bmx activity were fertile and had a normal life span without an obvious phenotype [7].
  • A transient transfection system was used to identify regulators and effectors for Tec and Bmx, members of the Tec non-receptor tyrosine kinase family [5].
  • We show here that Bmx expression is induced in skin keratinocytes during wound healing [1].
  • Bmx expression also induces chronic inflammation and angiogenesis in the skin, and gene expression profiling suggests that this occurs via cytokine-mediated recruitment of inflammatory cells [1].

Anatomical context of Bmx


Associations of Bmx with chemical compounds

  • Predominant expression of murine Bmx tyrosine kinase in the granulo-monocytic lineage [8].
  • A marked increase of luminal epithelial cell proliferation was observed in the Etk transgenic prostate, which may be attributed in part to the elevated activity of Akt and signal transducers and activators of transcription 3 (STAT3) [4].

Other interactions of Bmx

  • Activation of Bmx required phosphatidylinositol 3-kinase (PI-3K) as demonstrated by the ability of PI-3K inhibitors to block the activation signal [9].

Analytical, diagnostic and therapeutic context of Bmx

  • The nonreceptor tyrosine kinase Etk/BMX was originally identified from the human prostate xenograft CWR22 [4].
  • Thus, the therapeutic potential of BVP22 and HVP22 in Etk/GCV suicide gene therapy in this tumor system is not due to VP22 delivery of Etk into surrounding cells but rather is likely due to an enhanced intracellular effect [10].


  1. Bmx tyrosine kinase transgene induces skin hyperplasia, inflammatory angiogenesis, and accelerated wound healing. Paavonen, K., Ekman, N., Wirzenius, M., Rajantie, I., Poutanen, M., Alitalo, K. Mol. Biol. Cell (2004) [Pubmed]
  2. BMX, a novel nonreceptor tyrosine kinase gene of the BTK/ITK/TEC/TXK family located in chromosome Xp22.2. Tamagnone, L., Lahtinen, I., Mustonen, T., Virtaneva, K., Francis, F., Muscatelli, F., Alitalo, R., Smith, C.I., Larsson, C., Alitalo, K. Oncogene (1994) [Pubmed]
  3. Etk/Bmx tyrosine kinase activates Pak1 and regulates tumorigenicity of breast cancer cells. Bagheri-Yarmand, R., Mandal, M., Taludker, A.H., Wang, R.A., Vadlamudi, R.K., Kung, H.J., Kumar, R. J. Biol. Chem. (2001) [Pubmed]
  4. Tyrosine Kinase Etk/BMX Is Up-regulated in Human Prostate Cancer and Its Overexpression Induces Prostate Intraepithelial Neoplasia in Mouse. Dai, B., Kim, O., Xie, Y., Guo, Z., Xu, K., Wang, B., Kong, X., Melamed, J., Chen, H., Bieberich, C.J., Borowsky, A.D., Kung, H.J., Wei, G., Ostrowski, M.C., Brodie, A., Qiu, Y. Cancer Res. (2006) [Pubmed]
  5. Tec/Bmx non-receptor tyrosine kinases are involved in regulation of Rho and serum response factor by Galpha12/13. Mao, J., Xie, W., Yuan, H., Simon, M.I., Mano, H., Wu, D. EMBO J. (1998) [Pubmed]
  6. Bmx tyrosine kinase is specifically expressed in the endocardium and the endothelium of large arteries. Ekman, N., Lymboussaki, A., Västrik, I., Sarvas, K., Kaipainen, A., Alitalo, K. Circulation (1997) [Pubmed]
  7. Bmx tyrosine kinase has a redundant function downstream of angiopoietin and vascular endothelial growth factor receptors in arterial endothelium. Rajantie, I., Ekman, N., Iljin, K., Arighi, E., Gunji, Y., Kaukonen, J., Palotie, A., Dewerchin, M., Carmeliet, P., Alitalo, K. Mol. Cell. Biol. (2001) [Pubmed]
  8. Predominant expression of murine Bmx tyrosine kinase in the granulo-monocytic lineage. Weil, D., Power, M.A., Smith, S.I., Li, C.L. Blood (1997) [Pubmed]
  9. The Bmx tyrosine kinase is activated by IL-3 and G-CSF in a PI-3K dependent manner. Ekman, N., Arighi, E., Rajantie, I., Saharinen, P., Ristimäki, A., Silvennoinen, O., Alitalo, K. Oncogene (2000) [Pubmed]
  10. Bovine herpesvirus tegument protein VP22 enhances thymidine kinase/ganciclovir suicide gene therapy for neuroblastomas compared to herpes simplex virus VP22. Qiu, Z., Harms, J.S., Zhu, J., Splitter, G.A. J. Virol. (2004) [Pubmed]
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