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Gene Review

Ccna1  -  cyclin A1

Mus musculus

Synonyms: Cyclin-A1
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Disease relevance of Ccna1


High impact information on Ccna1


Biological context of Ccna1

  • Comparison of the mouse, rat, and human proximal promoters revealed regions of high sequence conservation and consensus sequences both for known transcription factors, some of which are coexpressed with Ccna1, such as A-myb and Hsf2, and for elements that control expression of genes in somatic cell cycles, such as CDE, CHR, and CCAAT elements [7].
  • Thus, the promoter region within 1.3 kb upstream of the putative Ccna1 transcriptional start can direct expression of lacZ to spermatocytes, while sequences located between -4.8 kb and -1.3 kb of the putative transcriptional start site may enhance expression of lacZ [7].
  • The gene encoding mouse cyclin A1, Ccna1, is expressed at highest levels in late pachytene-diplotene spermatocytes, where it is required for meiotic cell division [7].
  • Targeted disruption of the Ccna1 gene with a LacZ reporter gene has allowed us to study the expression pattern of this gene in more detail [8].
  • The specific localization of cyclin A and cdk2 at nuclear replication foci provides a direct link between cell cycle regulation and DNA replication [6].

Anatomical context of Ccna1

  • Cultured Brca1(FL/FL) cells exhibited abnormal centrosome amplification and reduction of G(1) population that was accompanied by accumulation of cyclin E and cyclin A. Accumulation of cyclin E was also found in epithelial layers of dilated ducts and hyperproliferative lobular regions in the mammary glands of Brca1(FL/FL) mice [9].
  • Absence of spermatids in a histological analysis, decreased expression of Ccna1 mRNA and the accumulation of SCP3-positive spermatocytes showed the arrest of spermatogenesis at the pachytene stage in the Dmrt7-knockout mice [10].
  • These mice display a 2-fold decrease in the number of Ki-67- or PCNA-positive cells at the time of peak hepatocyte proliferation at 40 hours, which coincided with decreased cyclin A, D, and E expression [11].
  • Overexpression of Six1 in wild-type mouse embryonic fibroblasts, but not in knockout variants lacking the cyclin A1 gene, induces cell proliferation [1].
  • Both genes are expressed in the embryonic but not the terminally differentiated mammary gland, and Six1-knockout mice show a dramatic reduction of cyclin A1 in the embryonic mammary gland [1].

Associations of Ccna1 with chemical compounds


Other interactions of Ccna1


Analytical, diagnostic and therapeutic context of Ccna1


  1. The Six1 homeoprotein stimulates tumorigenesis by reactivation of cyclin A1. Coletta, R.D., Christensen, K., Reichenberger, K.J., Lamb, J., Micomonaco, D., Huang, L., Wolf, D.M., Müller-Tidow, C., Golub, T.R., Kawakami, K., Ford, H.L. Proc. Natl. Acad. Sci. U.S.A. (2004) [Pubmed]
  2. Cell-cycle regulation and mammalian gametogenesis: a lesson from the unexpected. Kierszenbaum, A.L. Mol. Reprod. Dev. (2006) [Pubmed]
  3. A developmentally regulated and tissue-dependent transcription factor complexes with the retinoblastoma gene product. Partridge, J.F., La Thangue, N.B. EMBO J. (1991) [Pubmed]
  4. Cyclin A1 is required for meiosis in the male mouse. Liu, D., Matzuk, M.M., Sung, W.K., Guo, Q., Wang, P., Wolgemuth, D.J. Nat. Genet. (1998) [Pubmed]
  5. Delayed early embryonic lethality following disruption of the murine cyclin A2 gene. Murphy, M., Stinnakre, M.G., Senamaud-Beaufort, C., Winston, N.J., Sweeney, C., Kubelka, M., Carrington, M., Bréchot, C., Sobczak-Thépot, J. Nat. Genet. (1997) [Pubmed]
  6. Reversal of terminal differentiation and control of DNA replication: cyclin A and Cdk2 specifically localize at subnuclear sites of DNA replication. Cardoso, M.C., Leonhardt, H., Nadal-Ginard, B. Cell (1993) [Pubmed]
  7. Distinct regions of the mouse cyclin A1 gene, Ccna1, confer male germ-cell specific expression and enhancer function. Lele, K.M., Wolgemuth, D.J. Biol. Reprod. (2004) [Pubmed]
  8. Cyclin A1 protein shows haplo-insufficiency for normal fertility in male mice. van der Meer, T., Chan, W.Y., Palazon, L.S., Nieduszynski, C., Murphy, M., Sobczak-Thépot, J., Carrington, M., Colledge, W.H. Reproduction (2004) [Pubmed]
  9. Hyperplasia and spontaneous tumor development in the gynecologic system in mice lacking the BRCA1-Delta11 isoform. Kim, S.S., Cao, L., Lim, S.C., Li, C., Wang, R.H., Xu, X., Bachelier, R., Deng, C.X. Mol. Cell. Biol. (2006) [Pubmed]
  10. Mice deficient in Dmrt7 show infertility with spermatogenic arrest at pachytene stage. Kawamata, M., Nishimori, K. FEBS Lett. (2006) [Pubmed]
  11. Conditional Deletion of beta-Catenin Reveals Its Role in Liver Growth and Regeneration. Tan, X., Behari, J., Cieply, B., Michalopoulos, G.K., Monga, S.P. Gastroenterology (2006) [Pubmed]
  12. Proteasome inhibition attenuates hepatic injury in the bile duct-ligated mouse. Anan, A., Baskin-Bey, E.S., Isomoto, H., Mott, J.L., Bronk, S.F., Albrecht, J.H., Gores, G.J. Am. J. Physiol. Gastrointest. Liver Physiol. (2006) [Pubmed]
  13. Depletion of intracellular Ca2+ stores, phosphorylation of eIF2alpha, and sustained inhibition of translation initiation mediate the anticancer effects of clotrimazole. Aktas, H., Flückiger, R., Acosta, J.A., Savage, J.M., Palakurthi, S.S., Halperin, J.A. Proc. Natl. Acad. Sci. U.S.A. (1998) [Pubmed]
  14. Increased expression of cyclin A1 protein is associated with all-trans retinoic acid-induced apoptosis. Ekberg, J., Brunhoff, C., Järås, M., Fan, X., Landberg, G., Persson, J.L. Int. J. Biochem. Cell Biol. (2006) [Pubmed]
  15. Infertility with defective spermatogenesis and hypotestosteronemia in male mice lacking the androgen receptor in Sertoli cells. Chang, C., Chen, Y.T., Yeh, S.D., Xu, Q., Wang, R.S., Guillou, F., Lardy, H., Yeh, S. Proc. Natl. Acad. Sci. U.S.A. (2004) [Pubmed]
  16. Meiotic expression of the cyclin H/Cdk7 complex in male germ cells of the mouse. Kim, J.M., McGaughy, J.T., Bogle, R.K., Ravnik, S.E. Biol. Reprod. (2001) [Pubmed]
  17. Apoptosis was promoted at a nonpermissive temperature in DNA replication-defective temperature-sensitive mutants of mouse FM3A cells. Yamauchi, Y., Tanaka, A., Yamaguchi, K., Kobayashi, M., Shimamura, S., Hanaoka, F. Exp. Cell Res. (1998) [Pubmed]
  18. Posttranscriptional regulation of cyclin A1 and cyclin A2 during mouse oocyte meiotic maturation and preimplantation development. Fuchimoto, D., Mizukoshi, A., Schultz, R.M., Sakai, S., Aoki, F. Biol. Reprod. (2001) [Pubmed]
  19. Cell cycle regulatory proteins in the liver in murine Trypanosoma cruzi infection. Bouzahzah, B., Nagajyothi, F., Desruisseaux, M.S., Krishnamachary, M., Factor, S.M., Cohen, A.W., Lisanti, M.P., Petkova, S.B., Pestell, R.G., Wittner, M., Mukherjee, S., Weiss, L.M., Jelicks, L.A., Albanese, C., Tanowitz, H.B. Cell Cycle (2006) [Pubmed]
  20. Induced mitogenic activity in AML-12 mouse hepatocytes exposed to low-dose ultra-wideband electromagnetic radiation. Dorsey, W.C., Ford, B.D., Roane, L., Haynie, D.T., Tchounwou, P.B. International journal of environmental research and public health [electronic resource]. (2005) [Pubmed]
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