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Gene Review

Ccna1  -  cyclin A1

Rattus norvegicus

Synonyms: Cyclin-A1
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Disease relevance of Ccna1


High impact information on Ccna1


Chemical compound and disease context of Ccna1


Biological context of Ccna1

  • Further examination revealed that cyclin A continued to be ubiquitinated by the anaphase promoting complex (APC) and to be degraded by the proteasome [7].
  • The addition of SNP or SNAP to VSMC cultures at the time of serum stimulation abrogates the induction of cdk2 activity without suppressing protein levels of cdk2 or cyclin E. These NO donors block serum-stimulated upregulation of cyclin A mRNA and protein and repress the serum induction of cyclin A promoter activity in VSMCs [6].
  • In contrast, expression of cyclin E, cyclin A, and Rb phosphorylation were delayed when quiescent c-myc heterozygous cells were stimulated to enter the cell cycle [8].
  • The downstream effector of c-Myc is cyclin A, whose ectopic expression in c-myc(-/-) cells rescues the apoptosis defect [9].
  • The kinetics of the G(2) response indicate that the induction of cyclin A and the concomitant activation of Cdk2 represent an early step during commitment to apoptosis [9].

Anatomical context of Ccna1


Associations of Ccna1 with chemical compounds


Regulatory relationships of Ccna1

  • Deregulated expression of E2F-1 induces cyclin A- and E-associated kinase activities independently from cell cycle position [17].
  • Here we report that CTGF induces this S-phase entry by upregulating cyclin A levels [18].
  • We hypothesize that IFN-gamma inhibits cyclin A transcription by modifying co-activators or general transcription factors within the complex that drives transcription of the cyclin A gene [19].

Other interactions of Ccna1


Analytical, diagnostic and therapeutic context of Ccna1


  1. Increased cyclin A and decreased cyclin D levels in adenovirus 5 E1A-transformed rodent cell lines. Buchou, T., Kranenburg, O., van Dam, H., Roelen, D., Zantema, A., Hall, F.L., van der Eb, A. Oncogene (1993) [Pubmed]
  2. Nitric oxide inhibits ischemia/reperfusion-induced myocardial apoptosis by modulating cyclin A-associated kinase activity. Maejima, Y., Adachi, S., Ito, H., Nobori, K., Tamamori-Adachi, M., Isobe, M. Cardiovasc. Res. (2003) [Pubmed]
  3. Inhibition of DNA synthesis by RB: effects on G1/S transition and S-phase progression. Knudsen, E.S., Buckmaster, C., Chen, T.T., Feramisco, J.R., Wang, J.Y. Genes Dev. (1998) [Pubmed]
  4. Role of c-fos and E2F in the induction of cyclin A transcription and vascular smooth muscle cell proliferation. Sylvester, A.M., Chen, D., Krasinski, K., Andrés, V. J. Clin. Invest. (1998) [Pubmed]
  5. Downregulation of cyclin-dependent kinase 2 activity and cyclin A promoter activity in vascular smooth muscle cells by p27(KIP1), an inhibitor of neointima formation in the rat carotid artery. Chen, D., Krasinski, K., Sylvester, A., Chen, J., Nisen, P.D., Andrés, V. J. Clin. Invest. (1997) [Pubmed]
  6. Nitric oxide-induced downregulation of Cdk2 activity and cyclin A gene transcription in vascular smooth muscle cells. Guo, K., Andrés, V., Walsh, K. Circulation (1998) [Pubmed]
  7. Regulation of late G1/S phase transition and APC Cdh1 by reactive oxygen species. Havens, C.G., Ho, A., Yoshioka, N., Dowdy, S.F. Mol. Cell. Biol. (2006) [Pubmed]
  8. Effects of c-myc expression on cell cycle progression. Hanson, K.D., Shichiri, M., Follansbee, M.R., Sedivy, J.M. Mol. Cell. Biol. (1994) [Pubmed]
  9. c-Myc is necessary for DNA damage-induced apoptosis in the G(2) phase of the cell cycle. Adachi, S., Obaya, A.J., Han, Z., Ramos-Desimone, N., Wyche, J.H., Sedivy, J.M. Mol. Cell. Biol. (2001) [Pubmed]
  10. Extracellular ATP induces anchorage-independent expression of cyclin A and rescues the transformed phenotype of a ras-resistant mutant cell line. Yang, J.J., Krauss, R.S. J. Biol. Chem. (1997) [Pubmed]
  11. Aldosterone stimulates proliferation of mesangial cells by activating mitogen-activated protein kinase 1/2, cyclin D1, and cyclin A. Terada, Y., Kobayashi, T., Kuwana, H., Tanaka, H., Inoshita, S., Kuwahara, M., Sasaki, S. J. Am. Soc. Nephrol. (2005) [Pubmed]
  12. Altered regulation of smooth muscle cell proliferation and apoptosis in small arteries of spontaneously hypertensive rats. Díez, J., Fortuño, M.A., Zalba, G., Etayo, J.C., Fortuño, A., Ravassa, S., Beaumont, J. Eur. Heart J. (1998) [Pubmed]
  13. Differential regulation of cyclin D1 and D3 expression in the control of astrocyte proliferation induced by endothelin-1. Teixeira, A., Chaverot, N., Strosberg, A.D., Cazaubon, S. J. Neurochem. (2000) [Pubmed]
  14. p38 MAP kinase signaling is necessary for rat chondrosarcoma cell proliferation. Halawani, D., Mondeh, R., Stanton, L.A., Beier, F. Oncogene (2004) [Pubmed]
  15. Differential activation of cyclin and cyclin-dependent kinase genes by adenovirus E1A12S cDNA product. Ishii, T., Shimizu, M., Kanayama, Y., Nakada, S., Nojima, H., Oda, K. Exp. Cell Res. (1993) [Pubmed]
  16. Mitoinhibitory effects of the tumor promoter 2-acetylaminofluorene in rat liver: loss of E2F-1 and E2F-3 expression and cdk 2 kinase activity in late G1. Ohlson, L.C., Koroxenidou, L., Porsch-Hällström, I. J. Hepatol. (2004) [Pubmed]
  17. Deregulated expression of E2F-1 induces cyclin A- and E-associated kinase activities independently from cell cycle position. Soucek, T., Pusch, O., Hengstschläger-Ottnad, E., Adams, P.D., Hengstschläger, M. Oncogene (1997) [Pubmed]
  18. CTGF modulates cell cycle progression in cAMP-arrested NRK fibroblasts. Kothapalli, D., Grotendorst, G.R. J. Cell. Physiol. (2000) [Pubmed]
  19. Interferon-gamma-mediated inhibition of cyclin A gene transcription is independent of individual cis-acting elements in the cyclin A promoter. Sibinga, N.E., Wang, H., Perrella, M.A., Endege, W.O., Patterson, C., Yoshizumi, M., Haber, E., Lee, M.E. J. Biol. Chem. (1999) [Pubmed]
  20. Overexpression of the integrin-linked kinase promotes anchorage-independent cell cycle progression. Radeva, G., Petrocelli, T., Behrend, E., Leung-Hagesteijn, C., Filmus, J., Slingerland, J., Dedhar, S. J. Biol. Chem. (1997) [Pubmed]
  21. Cyclin A is a c-Jun target gene and is necessary for c-Jun-induced anchorage-independent growth in RAT1a cells. Katabami, M., Donninger, H., Hommura, F., Leaner, V.D., Kinoshita, I., Chick, J.F., Birrer, M.J. J. Biol. Chem. (2005) [Pubmed]
  22. 2-acetaminofluorene blocks cell cycle progression after hepatectomy by p21 induction and lack of cyclin E expression. Trautwein, C., Will, M., Kubicka, S., Rakemann, T., Flemming, P., Manns, M.P. Oncogene (1999) [Pubmed]
  23. A centrosomal localization signal in cyclin E required for Cdk2-independent S phase entry. Matsumoto, Y., Maller, J.L. Science (2004) [Pubmed]
  24. The CCAAT displacement protein/cut homeodomain protein represses osteocalcin gene transcription and forms complexes with the retinoblastoma protein-related protein p107 and cyclin A. van Gurp, M.F., Pratap, J., Luong, M., Javed, A., Hoffmann, H., Giordano, A., Stein, J.L., Neufeld, E.J., Lian, J.B., Stein, G.S., van Wijnen, A.J. Cancer Res. (1999) [Pubmed]
  25. Expression and function of the developmental gene Wnt-4 during experimental acute renal failure in rats. Terada, Y., Tanaka, H., Okado, T., Shimamura, H., Inoshita, S., Kuwahara, M., Sasaki, S. J. Am. Soc. Nephrol. (2003) [Pubmed]
  26. Mesangial cell proliferation mediated by PDGF and bFGF is determined by levels of the cyclin kinase inhibitor p27Kip1. Shankland, S.J., Pippin, J., Flanagan, M., Coats, S.R., Nangaku, M., Gordon, K.L., Roberts, J.M., Couser, W.G., Johnson, R.J. Kidney Int. (1997) [Pubmed]
  27. 2,3,7,8-tetrachlorodibenzo-p-dioxin-dependent release from contact inhibition in WB-F344 cells: involvement of cyclin A. Dietrich, C., Faust, D., Budt, S., Moskwa, M., Kunz, A., Bock, K.W., Oesch, F. Toxicol. Appl. Pharmacol. (2002) [Pubmed]
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