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Gene Review

Entpd2  -  ectonucleoside triphosphate...

Mus musculus

Synonyms: CD39 antigen-like 1, Cd39l1, Ecto-ATP diphosphohydrolase 2, Ecto-ATPDase 2, Ecto-ATPase 2, ...
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Disease relevance of Entpd2

  • Wild-type mouse hepatoma cells contain both constitutive and TCDD-inducible ecto-ATPase activity [1].
  • Neuroblasts-glia interaction in tissue culture as evidenced by the study of ectoenzymes. Ecto-ATPase activity of mouse neuroblastoma cells [2].

High impact information on Entpd2


Chemical compound and disease context of Entpd2


Biological context of Entpd2

  • In this context, NTPDase1 should abrogate platelet aggregation and recruitment in intact vessels by the conversion of ADP to adenosine monophosphate, while NTPDase2 expression would promote platelet microthrombus formation at sites of extravasation following vessel injury [3].
  • Induction of ecto-ATPase gene expression by TCDD is direct and occurs at the transcriptional level [1].
  • Furthermore, after mitosis, progenitor cells preferentially reveal an NTPDase2-positive phenotype [5].
  • These results show that the ecto-ATPase of J774 cells does not mediate the effects of ATP on these cells; that ATP4- and not MgATP2- promotes 86Rb+ efflux from these cells; and that hydrolysis of ATP is not required to effect this change in membrane permeability [6].
  • Tissue distribution of the ecto-ATPase showed that the highest levels of protein were expressed in muscle tissues (cardiac, skeletal, and smooth) and brain [7].

Anatomical context of Entpd2


Associations of Entpd2 with chemical compounds


Other interactions of Entpd2

  • Double-immunolabeling revealed that NTPDase2 is associated with subpopulations of glial fibrillary acidic protein-, nestin- and doublecortin-positive radial cells [5].
  • Our data therefore support a physiological role for NTPDase2 and other ectonucleotidases in the pancreas and salivary glands [13].
  • To test whether the resistance of CTL to ATP is due to a high activity of ecto-ATPase, four independent assays of ATPase activity were utilized to demonstrate the presence and relatively high activity of the ecto-ATPase(s) on CTL surface [9].
  • In agreement with this observation, NTPDase2 was located to the same membrane as GLAST, indicating that this enzyme is present in type I cells [14].

Analytical, diagnostic and therapeutic context of Entpd2


  1. A novel response to dioxin. Induction of ecto-ATPase gene expression. Gao, L., Dong, L., Whitlock, J.P. J. Biol. Chem. (1998) [Pubmed]
  2. Neuroblasts-glia interaction in tissue culture as evidenced by the study of ectoenzymes. Ecto-ATPase activity of mouse neuroblastoma cells. Stefanovic, V., Ciesielski-Treska, J., Mandel, P. Brain Res. (1977) [Pubmed]
  3. Differential catalytic properties and vascular topography of murine nucleoside triphosphate diphosphohydrolase 1 (NTPDase1) and NTPDase2 have implications for thromboregulation. Sévigny, J., Sundberg, C., Braun, N., Guckelberger, O., Csizmadia, E., Qawi, I., Imai, M., Zimmermann, H., Robson, S.C. Blood (2002) [Pubmed]
  4. Extracellular nucleotide signaling in adult neural stem cells: synergism with growth factor-mediated cellular proliferation. Mishra, S.K., Braun, N., Shukla, V., Füllgrabe, M., Schomerus, C., Korf, H.W., Gachet, C., Ikehara, Y., Sévigny, J., Robson, S.C., Zimmermann, H. Development (2006) [Pubmed]
  5. Functional expression of the ecto-ATPase NTPDase2 and of nucleotide receptors by neuronal progenitor cells in the adult murine hippocampus. Shukla, V., Zimmermann, H., Wang, L., Kettenmann, H., Raab, S., Hammer, K., Sévigny, J., Robson, S.C., Braun, N. J. Neurosci. Res. (2005) [Pubmed]
  6. Extracellular ATP4- promotes cation fluxes in the J774 mouse macrophage cell line. Steinberg, T.H., Silverstein, S.C. J. Biol. Chem. (1987) [Pubmed]
  7. Properties of and proteins associated with the extracellular ATPase of chicken gizzard smooth muscle. A monoclonal antibody study. Stout, J.G., Strobel, R.S., Kirley, T.L. J. Biol. Chem. (1995) [Pubmed]
  8. Expression of NTPDase1 and NTPDase2 in murine kidney: relevance to regulation of P2 receptor signaling. Kishore, B.K., Isaac, J., Fausther, M., Tripp, S.R., Shi, H., Gill, P.S., Braun, N., Zimmermann, H., Sévigny, J., Robson, S.C. Am. J. Physiol. Renal Physiol. (2005) [Pubmed]
  9. Ecto-ATPase activity in cytolytic T-lymphocytes. Protection from the cytolytic effects of extracellular ATP. Filippini, A., Taffs, R.E., Agui, T., Sitkovsky, M.V. J. Biol. Chem. (1990) [Pubmed]
  10. Genetic analysis of nucleotide triphosphatase activity in the mouse brain. Allen, K.M., Seyfried, T.N. Genetics (1994) [Pubmed]
  11. Ecto-ATPase activity on the surface of Trypanosoma cruzi and its possible role in the parasite-host cell interaction. Bisaggio, D.F., Peres-Sampaio, C.E., Meyer-Fernandes, J.R., Souto-Padrón, T. Parasitol. Res. (2003) [Pubmed]
  12. Ecto-ATPase activity in rat and mouse thymocytes and cytotoxic effects of various chemical substances in vitro. Hennighausen, G., Hehl, E.M., Rychly, J. Arch. Toxicol. Suppl. (1985) [Pubmed]
  13. Localization of nucleoside triphosphate diphosphohydrolase-1 (NTPDase1) and NTPDase2 in pancreas and salivary gland. Kittel, A., Pelletier, J., Bigonnesse, F., Guckelberger, O., Kordás, K., Braun, N., Robson, S.C., Sévigny, J. J. Histochem. Cytochem. (2004) [Pubmed]
  14. Nucleoside triphosphate diphosphohydrolase-2 is the ecto-ATPase of type I cells in taste buds. Bartel, D.L., Sullivan, S.L., Lavoie, E.G., Sévigny, J., Finger, T.E. J. Comp. Neurol. (2006) [Pubmed]
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