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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Bowman Capsule

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Disease relevance of Bowman Capsule

  • In conclusion, the authors propose the following sequence of events leading to FSGS lesions in the Thy1.1 tg mice: (1) PEC damage and denudation of Bowman's capsule segments; (2) podocyte hypertrophy and bridging; and (3) PEC proliferation with ECM production [1].
  • These findings suggest that recruitment of polymorphonuclear leukocytes in perivascular and periglomerular areas as well as in glomerular tufts, and subsequent extracellular release of NE in situ may play an important role in the development of renal vasculitis characterized by vascular necrosis, rupture of Bowman's capsule, and tuft necrosis [2].

High impact information on Bowman Capsule

  • Expression in the developing nephron is most prominent in mature tubules, with lesser staining in Bowman's capsule and the proximal ureteric bud [3].
  • In contrast, in biglycan-deficient kidneys the overexpression of fibrillin-1 was markedly attenuated and this was associated with cystic dilatation of Bowman's capsule and proximal tubules [4].
  • VGEC proliferation and production of PDGF may be involved in the restoration of the capillary wall but could also contribute to local capillary wall injury and proliferation of other cells in Bowman's capsule, interstitium, and tubules [5].
  • In normal glomeruli, HSPG was predominantly localized in the glomerular basement membrane and in the mesangium, and to minor extent in the basement membranes of tubules and Bowman's capsule [6].
  • The study showed that glomerular injuries such as glomerular adhesion to Bowman's capsule and crescent formation were more marked in glomeruli with S-protein and/or C9 in patients with IgA nephropathy [7].

Biological context of Bowman Capsule

  • By the 11th week of gestation, an intense reactivity for TGF alpha polipeptide was shown in the fetal kidney at the level of the proximal tubules and Bowman's capsule; distal tubules as well as all urinary structures from the collecting ducts to the pelvis were less reactive [8].
  • The urinary albumin/creatinine ratio (ACR), fasting and casual blood glucose levels, ratio of glomerular and Bowman's capsule volume (GB ratio), and systemic blood pressure were measured as phenotypic characterizations [9].

Anatomical context of Bowman Capsule


Associations of Bowman Capsule with chemical compounds


Gene context of Bowman Capsule

  • In particular within fetal kidney, intense expression of 11betaHSD2 and GR mRNA was observed over Bowman's capsule and the vascular tufts of developing glomeruli as they migrated from the surface of the kidney to the inner cortex [20].
  • VCAM-1 was constitutively expressed by Bowman's capsule and proximal tubules and was weakly induced on glomerular ECs by TNF and IL-4 in combination [21].
  • RESULTS: LRAT protein was detected at high levels in the epithelial cells in the tubules and the lining of Bowman's capsule in the glomeruli of normal, nonneoplastic kidney sections [22].
  • While elastin localized to the glomerular vascular pole in afferent and efferent arterioles extending to Bowman's capsule, it was not found in the glomerular capillary tuft [23].
  • In the kidney, renal tubuli showed MAO-A and MAO-B immunoreactivities, whereas collecting ducts and the Bowman's capsule showed only MAO-A staining [24].


  1. The parietal epithelial cell: a key player in the pathogenesis of focal segmental glomerulosclerosis in Thy-1.1 transgenic mice. Smeets, B., Te Loeke, N.A., Dijkman, H.B., Steenbergen, M.L., Lensen, J.F., Begieneman, M.P., van Kuppevelt, T.H., Wetzels, J.F., Steenbergen, E.J. J. Am. Soc. Nephrol. (2004) [Pubmed]
  2. Role of neutrophil elastase in the development of renal necrotizing vasculitis. Hotta, O., Oda, T., Taguma, Y., Kitamura, H., Chiba, S., Miyazawa, S., Nagura, H. Clin. Nephrol. (1996) [Pubmed]
  3. Polycystin, the polycystic kidney disease 1 protein, is expressed by epithelial cells in fetal, adult, and polycystic kidney. Ward, C.J., Turley, H., Ong, A.C., Comley, M., Biddolph, S., Chetty, R., Ratcliffe, P.J., Gattner, K., Harris, P.C. Proc. Natl. Acad. Sci. U.S.A. (1996) [Pubmed]
  4. Regulation of fibrillin-1 by biglycan and decorin is important for tissue preservation in the kidney during pressure-induced injury. Schaefer, L., Mihalik, D., Babelova, A., Krzyzankova, M., Gröne, H.J., Iozzo, R.V., Young, M.F., Seidler, D.G., Lin, G., Reinhardt, D.P., Schaefer, R.M. Am. J. Pathol. (2004) [Pubmed]
  5. Visceral glomerular epithelial cells can proliferate in vivo and synthesize platelet-derived growth factor B-chain. Floege, J., Johnson, R.J., Alpers, C.E., Fatemi-Nainie, S., Richardson, C.A., Gordon, K., Couser, W.G. Am. J. Pathol. (1993) [Pubmed]
  6. Immunohistochemical localization of extracellular matrix components in human diabetic glomerular lesions. Nerlich, A., Schleicher, E. Am. J. Pathol. (1991) [Pubmed]
  7. Immunofluorescent studies on S-protein in glomeruli from patients with IgA nephropathy. Tomino, Y., Yagame, M., Eguchi, K., Nomoto, Y., Sakai, H. Am. J. Pathol. (1987) [Pubmed]
  8. Immunohistochemical localization of the epidermal growth factor, transforming growth factor alpha, and their receptor in the human mesonephros and metanephros. Bernardini, N., Bianchi, F., Lupetti, M., Dolfi, A. Dev. Dyn. (1996) [Pubmed]
  9. Effect of pioglitazone on the early stage of type 2 diabetic nephropathy in KK/Ta mice. Tanimoto, M., Fan, Q., Gohda, T., Shike, T., Makita, Y., Tomino, Y. Metab. Clin. Exp. (2004) [Pubmed]
  10. Intraglomerular C3 synthesis in human kidney detected by in situ hybridization. Miyazaki, M., Abe, K., Koji, T., Furusu, A., Ozono, Y., Harada, T., Nakane, P.K., Yagame, M., Endoh, M., Nomoto, Y., Sakai, H. J. Am. Soc. Nephrol. (1996) [Pubmed]
  11. Developmental expression and function of aldehyde reductase in proximal tubules of the kidney. Barski, O.A., Papusha, V.Z., Ivanova, M.M., Rudman, D.M., Finegold, M.J. Am. J. Physiol. Renal Physiol. (2005) [Pubmed]
  12. Colocalization of demethylating enzymes and NOS and functional effects of methylarginines in rat kidney. Tojo, A., Welch, W.J., Bremer, V., Kimoto, M., Kimura, K., Omata, M., Ogawa, T., Vallance, P., Wilcox, C.S. Kidney Int. (1997) [Pubmed]
  13. Stage- and segment-specific expression of cell-adhesion molecules N-CAM, A-CAM, and L-CAM in the kidney. Nouwen, E.J., Dauwe, S., van der Biest, I., De Broe, M.E. Kidney Int. (1993) [Pubmed]
  14. Role of intrinsic renal cells versus infiltrating cells in glomerular crescent formation. Ophascharoensuk, V., Pippin, J.W., Gordon, K.L., Shankland, S.J., Couser, W.G., Johnson, R.J. Kidney Int. (1998) [Pubmed]
  15. Three-dimensional morphometric analysis of segmental glomerulosclerosis in the rat. Remuzzi, A., Pergolizzi, R., Mauer, M.S., Bertani, T. Kidney Int. (1990) [Pubmed]
  16. Purified P fimbriae from two cloned gene clusters of a single pyelonephritogenic strain adhere to unique structures in the human kidney. Karr, J.F., Nowicki, B., Truong, L.D., Hull, R.A., Hull, S.I. Infect. Immun. (1989) [Pubmed]
  17. Distribution of beta 1 and beta 3 integrins in human fetal and adult kidney. Korhonen, M., Ylänne, J., Laitinen, L., Virtanen, I. Lab. Invest. (1990) [Pubmed]
  18. Chronic renal denervation prevents glomerular hyperfiltration in diabetic rats. Luippold, G., Beilharz, M., Mühlbauer, B. Nephrol. Dial. Transplant. (2004) [Pubmed]
  19. Environmental cadmium induces histopathological changes in kidneys of roe deer. Beiglböck, C., Steineck, T., Tataruch, F., Ruf, T. Environ. Toxicol. Chem. (2002) [Pubmed]
  20. Expression of type 2 11beta-hydroxysteroid dehydrogenase and corticosteroid hormone receptors in early human fetal life. Condon, J., Gosden, C., Gardener, D., Nickson, P., Hewison, M., Howie, A.J., Stewart, P.M. J. Clin. Endocrinol. Metab. (1998) [Pubmed]
  21. Cell adhesion molecule expression within human glomerular and kidney organ culture. Savage, C.O., Brooks, C.J., Adu, D., Richards, G., Howie, A.J. J. Pathol. (1997) [Pubmed]
  22. Differential expression of the enzyme that esterifies retinol, lecithin:retinol acyltransferase, in subtypes of human renal cancer and normal kidney. Zhan, H.C., Gudas, L.J., Bok, D., Rando, R., Nanus, D.M., Tickoo, S.K. Clin. Cancer Res. (2003) [Pubmed]
  23. Elastic fiber proteins in the glomerular mesangium in vivo and in cell culture. Sterzel, R.B., Hartner, A., Schlötzer-Schrehardt, U., Voit, S., Hausknecht, B., Doliana, R., Colombatti, A., Gibson, M.A., Braghetta, P., Bressan, G.M. Kidney Int. (2000) [Pubmed]
  24. Cellular localization of monoamine oxidase A and B in human tissues outside of the central nervous system. Rodríguez, M.J., Saura, J., Billett, E.E., Finch, C.C., Mahy, N. Cell Tissue Res. (2001) [Pubmed]
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