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Gene Review

5.4  -  gp5.4 conserved hypothetical protein

Enterobacteria phage T4

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Disease relevance of 5.4

  • For basal-cell carcinoma, the annualised rates of new lesions were 3.8 in the treatment group and 5.4 in the placebo group (difference 1.6 [0.38-2.82]) [1].
  • The affected family members were clinically euthyroid but all had goiters and markedly increased serum thyroid hormone levels: thyroxine (T4) = 21.1 +/- 2.1 microgram/dl; triiodothyronine (T3) = 323 +/- 60 ng/dl; free T4 = 5.4 +/- 0.9 ng/dl; and free T3 = 1,134 +/- 356 pg/dl (mean +/- SD) [2].
  • At 20 and 60 minutes after protirelin administration, serum TSH levels were, respectively, 3.3 +/- 2.7 microU/mL and 2.6 +/- 2.3 microU/mL in patients with Cushing's syndrome and 12.3 +/- 5.4 microU/mL and 10.7 +/- 5.4 microU/mL in normal subjects (P less than .001) [3].
  • Of patients with metastases, the survival time of those with liver metastases was found to be the shortest, 5.4 +/- 0.5 months (mean +/- SEM) [4].
  • As compared to control rats of the same body weight kept at 25 degrees C, rats exposed to 34 degrees C for 3-4 weeks exhibited a retarded growth-rate: 2.3 vs 4.0 g/day, a reduced food-intake: 15.2 vs 23.2 g/day, a decreased T4 production-rate: 1.8 vs 2.7 micrograms/day and a decreased oxygen consumption: 4.0 vs 5.4 ml/min [5].

High impact information on 5.4

  • METHODS: We measured serum free thyroxine 4 (free T4), free T3, and thyrotropin hormone (TSH) and the prevalence of thyroid autoantibodies (antithyroglobulin and antithyroperoxidase), in 287 children or adolescents living in Hoiniki (average caesium contamination of 5.4 Ci/km2) [6].
  • Unlabeled T3, L-thyroxine (T4), 3,5,3'-triiodo-D-thyronine, and triiodothyroacetic acid inhibited T3 uptake with Kl values of 0.32, 1.4, 4.1, and 5.4 microM, respectively, indicating specificity of uptake which was different from specificity of intracellular binding sites [7].
  • 3. In the presence of AC, a small percentage of T4 cells (5.4 to 11.7%) was stimulated to produce detectable amounts of IL-2 by either immobilized or soluble PHA [8].
  • At 1.0 M NaClO4 and 21 degrees C, delta GB-Z = 5.4, 4.9, 3.6 and 2.3 kcal/mole for the G4, T4, A4 and C4 loop hairpins, respectively [9].
  • Despite the fact that rT3 levels may be elevated in amniotic fluid and that rT3 is expected to represent the major source from which extrathyroidal T2 arises, T2 levels were low in amniotic fluid, being undetectable (less than 2 ng/dl) in 9 of 19 samples; the mean (+/-SE) T2 concentration in the 10 detectable samples was 5.4 +/- 1 ng/dl [10].

Chemical compound and disease context of 5.4

  • Moreover, although the overall incidence of hypotension was not different (multiple pregnancy; 65% vs 58% in singletons), ephedrine (5.4 +/- 5.3 mg vs 10.7 +/- 13.8 mg; P < 0.05) and additional fluid requirements during onset of the block (4.3 +/- 1.7 mL/kg vs 5.3 +/- 2.6 mL/kg; P = 0.03) were less than in singletons [11].

Biological context of 5.4

  • There was a progressive reduction in energy intake from 5.4 MJ/d for T2 pigs to 3.0 MJ/d for T4 and T5 pigs (P less than 0.001) [12].
  • The patients treated at Ito hospital were then divided into 4 groups according to their FT4 levels (A: < or =2.3, B: >2.3 approximately < or =3.9, C: 3.9 approximately < or =5.4, D: >5.4 ng/dl), and the AUC, cut-off points, sensitivity, and specificity of the FT(3)/FT(4) ratios were calculated [13].

Anatomical context of 5.4


Associations of 5.4 with chemical compounds

  • Methimazole (MMI) administration to the mothers caused a 5.4- and 1.7-fold decrease in neonatal plasma concentrations of L-thyroxine (T4) and 3,5,3'-triiodo-L-thyronine (T3), respectively [15].
  • They received preoperative radiation over 6 weeks to 45 Gy and boost of 5.4 Gy and concurrent continuous infusion 5-fluorouracil 250 mg m(-2) day(-1) and weekly irinotecan 40 mg m(-2) [16].
  • Mean +/- SD serum concentration of T4 (27.9 +/- 10.3 to 11.7 +/- 6.4 nmol/L) and estimate of fT4 concentration (21.7 +/- 5.4 to 10.4 +/- 4.4 pmol/L) decreased significantly (P less than 0.001) in response to administration of liothyronine [17].
  • This post-excitatory depression began 11 +/- 5.4 (S.D.) seconds after injection of serotonin and 6.6 +/- 5.3 seconds after the peak neural discharge [18].
  • The mean post T4 uptake in group I was 18.8 +/- 3.3% during PTU therapy and 5.4 +/- 1.3% during MMI therapy.(ABSTRACT TRUNCATED AT 250 WORDS)[19]

Other interactions of 5.4

  • SHBG concentration rose from 38.1 +/- 18.3 to 54.3 +/- 16.0 nmol/l (P less than 0.01), while T and E2 showed significant increases from 31.2 +/- 10.8 nmol/l and 24.6 +/- 5.4 pg/ml to 52.0 +/- 3.6 and 43.3 +/- 14.9, respectively in the oligozoospermic patients, with similar rises noted in the normospermic men [20].
  • The onset of complete motor block (9.9 [5.3] vs 13.8 [5.4] min, P = 0.027) and complete recovery (144.8 [28.4] vs 218.5 [56.8] min, P < 0.001) was also faster [21].

Analytical, diagnostic and therapeutic context of 5.4

  • Con A-induced BIF (m.w. of 80,000 and an isoelectric point of pH 5.4) was analyzed by Sephadex G-200 gel filtration and chromatofocusing [22].
  • Diabetes, hypophysectomy, and thyroidectomy lowered these values to 79 +/- 5.4, 60 +/- 5.8, and 30 +/- 1.6 ng/dl for T3 and 3.5 +/- 0.3, 2.7 +/- 0.4, and 1.9 +/- 0.2 micrograms/dl for T4, respectively [23].
  • Pelvic radiotherapy was delivered at a dose of 45 Gy in 25 fractions in 5 weeks followed by a 5.4 Gy boost at 1.8 Gy daily [24].


  1. Effect of topically applied T4 endonuclease V in liposomes on skin cancer in xeroderma pigmentosum: a randomised study. Xeroderma Pigmentosum Study Group. Yarosh, D., Klein, J., O'Connor, A., Hawk, J., Rafal, E., Wolf, P. Lancet (2001) [Pubmed]
  2. Familial thyroid hormone resistance. Brooks, M.H., Barbato, A.L., Collins, S., Garbincius, J., Neidballa, R.G., Hoffman, D. Am. J. Med. (1981) [Pubmed]
  3. Thyroid axis in patients with Cushing's syndrome. Duick, D.S., Wahner, H.W. Arch. Intern. Med. (1979) [Pubmed]
  4. Nasopharyngeal carcinoma in Taiwan. Clinical manifestations and results of therapy. Hsu, M.M., Tu, S.M. Cancer (1983) [Pubmed]
  5. Metabolic alterations induced by chronic heat exposure in the rat: the involvement of thyroid function. Rousset, B., Cure, M., Jordan, D., Kervran, A., Bornet, H., Mornex, R. Pflugers Arch. (1984) [Pubmed]
  6. Prevalence of thyroid autoantibodies in children and adolescents from Belarus exposed to the Chernobyl radioactive fallout. Pacini, F., Vorontsova, T., Molinaro, E., Kuchinskaya, E., Agate, L., Shavrova, E., Astachova, L., Chiovato, L., Pinchera, A. Lancet (1998) [Pubmed]
  7. Characterization of the thyroid hormone transport system of isolated hepatocytes. Blondeau, J.P., Osty, J., Francon, J. J. Biol. Chem. (1988) [Pubmed]
  8. T4 cell activation by immobilized phytohemagglutinin: differential capacity to induce IL-2 responsiveness and IL-2 production. Vine, J.B., Geppert, T.D., Lipsky, P.E. J. Immunol. (1988) [Pubmed]
  9. B to Z transitions of the short DNA hairpins formed from the oligomer sequences: d[(CG)3X4(CG)3] (X = A, T, G, C). Amaratunga, M., Pancoska, P., Paner, T.M., Benight, A.S. Nucleic Acids Res. (1990) [Pubmed]
  10. A radioimmunoassay for 3',5'-diiodothyronine. Burman, K.D., Wright, F.D., Smallridge, R.C., Green, B.J., Georges, L.P., Wartofsky, L. J. Clin. Endocrinol. Metab. (1978) [Pubmed]
  11. Epidural anaesthesia for caesarean delivery in triple and quadruple pregnancies. Behforouz, N., Dounas, M., Benhamou, D. Acta anaesthesiologica Scandinavica. (1998) [Pubmed]
  12. Energy metabolism and body composition of young pigs given low-protein diets. McCracken, K.J., McAllister, A. Br. J. Nutr. (1984) [Pubmed]
  13. Ratio of serum free triiodothyronine to free thyroxine in Graves' hyperthyroidism and thyrotoxicosis caused by painless thyroiditis. Yoshimura Noh, J., Momotani, N., Fukada, S., Ito, K., Miyauchi, A., Amino, N. Endocr. J. (2005) [Pubmed]
  14. A rational approach to pulmonary screening in newly diagnosed head and neck cancer. Loh, K.S., Brown, D.H., Baker, J.T., Gilbert, R.W., Gullane, P.J., Irish, J.C. Head & neck. (2005) [Pubmed]
  15. Fuel utilization by early newborn brain is preserved under congenital hypothyroidism in the rat. Almeida, A., González-Buitrago, J.M., Bolaños, J.P., Medina, J.M. Pediatr. Res. (1996) [Pubmed]
  16. Intensified concurrent chemoradiotherapy with 5-fluorouracil and irinotecan as neoadjuvant treatment in patients with locally advanced rectal cancer. Klautke, G., Feyerherd, P., Ludwig, K., Prall, F., Foitzik, T., Fietkau, R. Br. J. Cancer (2005) [Pubmed]
  17. Use of the triiodothyronine suppression test for diagnosis of hyperthyroidism in ill cats that have serum concentration of iodothyronines within normal range. Refsal, K.R., Nachreiner, R.F., Stein, B.E., Currigan, C.E., Zendel, A.N., Thacker, E.L. J. Am. Vet. Med. Assoc. (1991) [Pubmed]
  18. Post-excitatory depression in thoracic sympathetic efferent neural traffic during a cardiogenic hypertensive chemoreflex. Kilbourne, E.M., Hageman, G.R., James, T.N., Urthaler, F. Basic Res. Cardiol. (1982) [Pubmed]
  19. T4 suppression test involving 24-hour thyroidal 131I uptake in patients with Graves' disease compared to the T3 suppression test. Kobayashi, I., Ishii, H., Mori, M., Kobayashi, S. Endocrinol. Jpn. (1984) [Pubmed]
  20. The effect of clomiphene citrate on sex hormone binding globulin in normospermic and oligozoospermic men. Adamopoulos, D.A., Vassilopoulos, P., Kapolla, N., Kontogeorgos, L. Int. J. Androl. (1981) [Pubmed]
  21. Spinal ropivacaine for cesarean delivery: a comparison of hyperbaric and plain solutions. Khaw, K.S., Ngan Kee, W.D., Wong, M., Ng, F., Lee, A. Anesth. Analg. (2002) [Pubmed]
  22. Identification and characterization of a B cell growth inhibitory factor (BIF) on BCGF-dependent B cell proliferation. Kawano, M., Iwato, K., Kuramoto, A. J. Immunol. (1985) [Pubmed]
  23. Diabetes, hypophysectomy, or thyroidectomy reduces nuclear L-triiodothyronine-binding capacity of rat lung. Das, D.K., Ganguly, M. Endocrinology (1981) [Pubmed]
  24. Oxaliplatin with raltitrexed and preoperative radiotherapy in T3-T4 extraperitoneal rectal cancer. A dose finding study. Lupattelli, M., Bellavita, R., Natalini, G., Giovenali, P., Sidoni, A., Castagnoli, P., Corgna, E., Draghini, L., Trippolini, R., Aristei, C. Tumori (2006) [Pubmed]
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