The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review


Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Hypopharynx


High impact information on Hypopharynx

  • Solid food entered and traversed the pharynx at the midline, whereas liquid bolus was split around the larynx and rejoined in the hypopharynx [6].
  • MATERIALS AND METHODS: Clinical records from 1987 to 1999 of 161 patients with head and neck SCC (oral cavity, 80 patients; larynx, 50; hypopharynx, 19; oropharynx, 12) who underwent preoperative radiation therapy and surgery were retrospectively reviewed [7].
  • The preservation of drug sensitivity and resistance under the conditions of our organoid culture assay (OCA) was demonstrated by investigating 3 strains of a human hypopharynx carcinoma which differed by different sensitivity to cisplatin in in vivo conditions [8].
  • The increased expression of hPGFS in SCCHN was primarily detected in SCC of larynx and hypopharynx (59%, P<0.05) [9].
  • RESULTS: In total, 54 of 74 primary tumors were found to be Hsp70 membrane-positive (73%); tongue/mouth, 21 of 24 (88%); oropharynx, 13 of 20 (65%); hypopharynx, 3 of 6 (50%); larynx, 8 of 11 (73%); trachea 1 of 2 (50%); esophagus, 4 of 5 (80%); lymph node metastases, 4 of 6 (67%) [10].

Chemical compound and disease context of Hypopharynx


Biological context of Hypopharynx


Anatomical context of Hypopharynx

  • Critique of "adjuvant intravenous methotrexate of definitive radiotherapy alone for advanced squamous cancers of the oral cavity, oropharynx, supraglottic larynx or hypopharynx. Concluding report of an RTOG randomized trial on 638 patients" [19].
  • For larynx and hypopharynx, excluding T1-T2 true vocal cord, there was a significant effect of total dose and fraction size [20].
  • The upper (proximal) section was adjacent to the base of the tongue at the level of C1 or C2 vertebrae pushing the tongue forward and its lower (distal) end was in the inferior recesses of the hypopharynx at the levels of C4 to T1 vertebrae [21].
  • BACKGROUND: Pharyngolaryngo-esophagectomy and pharyngogastric anastomosis (PLO & PGA) is one of the surgical options in the management of tumors arising from the hypopharynx and cervical esophagus [22].
  • Computed tomography (CT) of the cervical spine was obtained immediately following metrizamide myelography; it demonstrated a soft-tissue mass in the enlarged intervertebral foramen that extended posteriorly to compress the spinal cord and anteriorly to compress the hypopharynx [23].

Associations of Hypopharynx with chemical compounds

  • Blood concentration of lipid-bound sialic acid (LBSA), prostaglandin E (PGE) and histamine were determined in 37 patients with carcinoma of hypopharynx and larynx (supraglottic and glottic), in 12 non-cancer patients and in 10 healthy subjects [24].
  • The upper oesophageal sphincter fails to protect the hypopharynx under general anaesthesia even if patients do not receive a muscle relaxant [3].
  • In the CSM tumour this treatment modality caused a significantly (P < 0.05) higher growth delay as compared with the results obtained with 5-FU alone, whereas in the hypopharynx carcinoma the additional application of thymidine caused no significant change in tumor growth [25].
  • METHODS: We studied the ability of the PLMA to isolate the airway in 103 anaesthetized adults who were breathing spontaneously or given neuromuscular blocking agents, by filling the hypopharynx with methylene blue-dyed saline introduced down the drainage tube once the mask was in place [26].
  • Endoscopic diagnosis of thermal injury to the laryngopharynx after crack cocaine ingestion [27].

Gene context of Hypopharynx


Analytical, diagnostic and therapeutic context of Hypopharynx


  1. Expression of CD34, alpha-smooth muscle actin, and transforming growth factor beta1 in squamous intraepithelial lesions and squamous cell carcinoma of the larynx and hypopharynx. Kojc, N., Zidar, N., Vodopivec, B., Gale, N. Hum. Pathol. (2005) [Pubmed]
  2. Prognosis of primarily treated localized laryngeal carcinoma ameliorated through levamisole treatment: a randomized pilot study. Mussche, R.A., Kluyskens, P. Oncology (1980) [Pubmed]
  3. Upper oesophageal sphincter function during general anaesthesia. McGrath, J.P., McCaul, C., Byrne, P.J., Walsh, T.N., Hennessy, T.P. The British journal of surgery. (1996) [Pubmed]
  4. A phase I/II study of the hypoxic cell sensitizer misonidazole as an adjunct to high fractional dose radiotherapy in patients with unresectable squamous cell carcinoma of the head and neck: a RTOG randomized study (#79-04). Lee, D.J., Pajak, T.F., Stetz, J., Order, S.E., Weissberg, J.B., Fischer, J.J. Int. J. Radiat. Oncol. Biol. Phys. (1989) [Pubmed]
  5. Prognostic factors for local control in hypopharyngeal cancer treated with radical irradiation. Toita, T., Nakano, M., Ogawa, K., Koja, S., Maeshiro, N., Kakihana, Y., Yamaguchi, K. Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]. (1996) [Pubmed]
  6. Coordination of deglutitive glottal function and pharyngeal bolus transit during normal eating. Dua, K.S., Ren, J., Bardan, E., Xie, P., Shaker, R. Gastroenterology (1997) [Pubmed]
  7. Risk factors for local-regional recurrence following preoperative radiation therapy and surgery for head and neck cancer (stage II-IVB). Shikama, N., Sasaki, S., Nishikawa, A., Koiwai, K., Yoshino, F., Hirase, Y., Kawakami, R., Kadoya, M., Oguchi, M. Radiology. (2003) [Pubmed]
  8. An organoid culture assay (OCA) for determining the drug sensitivity of human tumors. Köpf-Maier, P., Kolon, B. Int. J. Cancer (1992) [Pubmed]
  9. Preferential expression of hPGFS in primary SCCHN and tumour cell lines derived from respiratory and digestive organs. Li, S., Hanna, E., Breau, R., Ratanatharathorn, V., Xia, X., Suen, J. Br. J. Cancer (2004) [Pubmed]
  10. Heat shock protein 70 (Hsp70) membrane expression on head-and-neck cancer biopsy-a target for natural killer (NK) cells. Kleinjung, T., Arndt, O., Feldmann, H.J., Bockmühl, U., Gehrmann, M., Zilch, T., Pfister, K., Schönberger, J., Marienhagen, J., Eilles, C., Rossbacher, L., Multhoff, G. Int. J. Radiat. Oncol. Biol. Phys. (2003) [Pubmed]
  11. Phase I clinical trial f mitoxantrone: a new anthracenedione anticancer drug. Alberts, D.S., Griffith, K.S., Goodman, G.E., Herman, T.S., Murray, E. Cancer Chemother. Pharmacol. (1980) [Pubmed]
  12. Radiotherapy alone or combined with carbogen breathing for squamous cell carcinoma of the head and neck: a prospective, randomized trial. Mendenhall, W.M., Morris, C.G., Amdur, R.J., Mendenhall, N.P., Siemann, D.W. Cancer (2005) [Pubmed]
  13. Is surgery necessary in stage III and stage IV cancer of the head and neck that responds to induction chemotherapy? Poulsen, M., Aldren, C., Tripcony, L., Walker, Q. Arch. Otolaryngol. Head Neck Surg. (1996) [Pubmed]
  14. Functional long-term outcome of a free jejunal transplant reconstruction following chemoradiotherapy and radical resection for hypopharyngeal and proximal oesophageal carcinoma. Bergquist, H., Ejnell, H., Fogdestam, I., Mark, H., Mercke, C., Lundell, L., Ruth, M. Digestive surgery. (2004) [Pubmed]
  15. Pretreatment evaluation of carcinomas of the hypopharynx and larynx with 18F-fluorodeoxyglucose, 123I-alpha-methyl-L-tyrosine and 99mTc-hexakis-2-methoxyisobutylisonitrile. Henze, M., Mohammed, A., Mier, W., Rudat, V., Dietz, A., Nollert, J., Eisenhut, M., Haberkorn, U. Eur. J. Nucl. Med. Mol. Imaging (2002) [Pubmed]
  16. p53 tumor suppressor oncogene expression in squamous cell carcinoma of the hypopharynx. Frank, J.L., Bur, M.E., Garb, J.L., Kay, S., Ware, J.L., Sismanis, A., Neifeld, J.P. Cancer (1994) [Pubmed]
  17. Sampling technique and rheology of human tracheobronchial mucus. Jeanneret-Grosjean, A., King, M., Michoud, M.C., Liote, H., Amyot, R. Am. Rev. Respir. Dis. (1988) [Pubmed]
  18. Distribution and prognostic significance of cell cycle proteins in squamous carcinoma of the larynx, hypopharynx and adjacent epithelial hyperplastic lesions. Volavsek, M., Bracko, M., Gale, N. The Journal of laryngology and otology. (2003) [Pubmed]
  19. Critique of "adjuvant intravenous methotrexate of definitive radiotherapy alone for advanced squamous cancers of the oral cavity, oropharynx, supraglottic larynx or hypopharynx. Concluding report of an RTOG randomized trial on 638 patients". Reay-Young, P. Int. J. Radiat. Oncol. Biol. Phys. (1981) [Pubmed]
  20. Dose, time, and fraction size issues for late effects in head and neck cancers. Taylor, J.M., Mendenhall, W.M., Lavey, R.S. Int. J. Radiat. Oncol. Biol. Phys. (1992) [Pubmed]
  21. Radiologic localization of the laryngeal mask airway in children. Goudsouzian, N.G., Denman, W., Cleveland, R., Shorten, G. Anesthesiology (1992) [Pubmed]
  22. Current status of pharyngolaryngo-esophagectomy and pharyngogastric anastomosis. Wei, W.I., Lam, L.K., Yuen, P.W., Wong, J. Head & neck. (1998) [Pubmed]
  23. Cervical chordoma presenting with intervertebral foramen enlargement mimicking neurofibroma: CT findings. Wang, A.M., Joachim, C.L., Shillito, J., Morris, J.H., Zamani, A.A., Rumbaugh, C.L. Journal of computer assisted tomography. (1984) [Pubmed]
  24. Lipid-bound sialic acid, prostaglandin E and histamine in head and neck cancer. Klapan, I., Katić, V., Culo, F., Sabolović, D., Cuk, V., Fumić, K., Simović, S. Eur. J. Cancer (1993) [Pubmed]
  25. 5-Fluorouracil metabolism and cytotoxicity after pre-treatment with methotrexate or thymidine in human hypopharynx and colon carcinoma xenografts: a 19F-nuclear magnetic resonance spectroscopy study in vivo. Tausch-Treml, R., Baumgart, F., Ziessow, D., Köpf-Maier, P. Cancer Chemother. Pharmacol. (1996) [Pubmed]
  26. ProSeal laryngeal mask protects against aspiration of fluid in the pharynx. Evans, N.R., Gardner, S.V., James, M.F. British journal of anaesthesia. (2002) [Pubmed]
  27. Endoscopic diagnosis of thermal injury to the laryngopharynx after crack cocaine ingestion. Ginsberg, G.G., Lipman, T.O. Gastrointest. Endosc. (1993) [Pubmed]
  28. Immunohistochemical study of p53, EGF, EGF-receptor, v-erb B and ras p21 in squamous cell carcinoma of hypopharynx. Otsu, M., Hayashi, Y., Amatsu, M., Itoh, H. The Kobe journal of medical sciences. (1994) [Pubmed]
  29. Cytokeratin 18 expression in squamous cell carcinoma of the head and neck. Balm, A.J., Hageman, P.C., van Doornewaard, M.H., Groeneveld, E.M., Ivanyi, D. European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery. (1996) [Pubmed]
  30. Clinicopathologic significance of CD105 expression in squamous cell carcinoma of the hypopharynx. Chien, C.Y., Su, C.Y., Hwang, C.F., Chuang, H.C., Hsiao, Y.C., Wu, S.L., Huang, C.C. Head & neck. (2006) [Pubmed]
  31. Inducible nitric oxide synthase expression in pharyngeal squamous cell carcinoma: relation to p53 expression, clinicopathological data, and survival. Pukkila, M.J., Kellokoski, J.K., Virtaniemi, J.A., Kumpulainen, E.J., Johansson, R.T., Halonen, P.M., Kosunen, A.S., Nuutinen, J., Kosma, V.M. Laryngoscope (2002) [Pubmed]
  32. Expression of hepatocyte growth factor and c-Met in hypopharyngeal squamous cell carcinoma. Kim, C.H., Moon, S.K., Bae, J.H., Lee, J.H., Han, J.H., Kim, K., Choi, E.C. Acta Otolaryngol. (2006) [Pubmed]
  33. Complications in transoral CO2 laser surgery for carcinoma of the larynx and hypopharynx. Vilaseca-González, I., Bernal-Sprekelsen, M., Blanch-Alejandro, J.L., Moragas-Lluis, M. Head & neck. (2003) [Pubmed]
  34. Nuclear and cytoplasmic p53 expression in pharyngeal squamous cell carcinoma: prognostic implications. Pukkila, M.J., Kumpulainen, E.J., Virtaniemi, J.A., Johansson, R.T., Halonen, P.M., Kellokoski, J.K., Kosunen, A.S., Nuutinen, J., Kosma, V.M. Head & neck. (2002) [Pubmed]
  35. Surgical criteria for obstructive sleep apnea syndrome based on localization of upper airway collapse during sleep: a preliminary study. Ikeda, K., Oshima, T., Shimomura, A., Takasaka, T. Tohoku J. Exp. Med. (1998) [Pubmed]
  36. Combined pre-operative telecobalt therapy and supraglottic laryngectomy. Sellars, S.L., Mills, E.E., Seid, A.B. The Journal of laryngology and otology. (1981) [Pubmed]
WikiGenes - Universities