High impact information on C1orf102

• However, the hOSCP1-expressing oocyte did not mediate the transport of L-carnitine [1].
• The transport of PAH by hOSCP1 was sensitive to pH, but the tetraethylammonium was not transported at the high pH examined. hOSCP1 transported prostaglandin E(2), prostaglandin F(2alpha), estrone sulfate, glutarate, L-leucine, L-ascorbic acid, and tetracycline [1].
• Thus, hOSCP1 also showed broad substrate specificity [1].
• The isolated cDNA consisted of 1137 base pairs that encoded a 379-amino acid protein, hOSCP1 [1].
• Northern blot and reverse transcription PCR analyses revealed that the hOSCP1 mRNA is expressed in the placenta and testis and weakly expressed in the thymus and small intestine [1].

Biological context of C1orf102

• In contrast to the enzyme containing native OSCP, FRET could be irreversibly lowered for the enzyme containing G166N at a rate that correlated closely with the rate of enzyme activity (ATP hydrolysis) [2].
• We show that interaction between two candidate proteins of the second stalk, OSCP and subunit b, fused at their C-termini to GFP variants and assembled into functional mtATPase can be monitored in mitochondria using fluorescence resonance energy transfer (FRET) [2].

Anatomical context of C1orf102

• Immunohistochemical analysis revealed that the hOSCP1 protein is localized in the basal membrane of the syncytiotrophoblast in the human placenta [1].
• Cloning, expression, and mutation analysis of NOR1, a novel human gene down-regulated in HNE1 nasopharyngeal carcinoma cell line [3].

Associations of C1orf102 with chemical compounds

• When expressed in Xenopus laevis oocytes, hOSCP1 mediated the high affinity transport of p-aminohippurate (PAH) (K(m) = 35.0 +/- 7.5 microm) and tetraethylammonium (K(m) = 62.3 +/- 12.2 microm) in a sodium-independent manner [1].
• Its first stable biosynthetic precursor is the anthraquinone norsolorinic acid (compound 3. ), which accumulates in the Aspergillus mutant strain NOR-1 [4].
• RESULTS: The N-acetylcysteamine (NAC) thioester of hexanoic acid was shown to efficiently support the biosynthesis of norsolorinic acid (compound 3. ) in the NOR-1 strain [4].
• A significant decrease in bacterial titers was observed for the ceftazidime-treated rats infected with E. cloacae NOR-1 only [5].
• The chromosomally located cephalosporinase and carbapenem-hydrolyzing beta-lactamase NmcA were inducible by cefoxitin and meropenem in E. cloacae NOR-1, and both were stably overproduced in the ceftazidime-resistant mutant [5].

Analytical, diagnostic and therapeutic context of C1orf102

• Despite the relative low MIC of meropenem for E. cloacae NOR-1, the carbapenem-treated rats had no decrease in bacterial counts in their lungs 60 h after therapy onset compared to the counts for the controls, regardless of whether E. cloacae NOR-1 or its ceftazidime-resistant mutant was inoculated [5].

References