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Gene Review

Cryz  -  crystallin, zeta

Mus musculus

Synonyms: NADPH:quinone reductase, Quinone oxidoreductase, SEZ9, Sez9, Zeta-crystallin, ...
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Disease relevance of Cryz


High impact information on Cryz

  • To gain information on bioreductive enzymes involved in the activation of KS119, cytotoxicity was measured in CHO cell lines overexpressing NADH:cytochrome b5 reductase (NBR), NADPH:cytochrome P450 reductase (NPR), or NADPH: quinone oxidoreductase 1 (NQO1) [4].
  • Zeta-Crystallin is a taxon-specific crystallin, an enzyme which has undergone direct gene recruitment as a structural component of the guinea pig lens through a Pax6-dependent mechanism [5].
  • Complexes binding the MARE in lens nuclear extracts are antigenically related to Nrl, and cotransfection with Nrl elevates zeta-crystallin promoter activity in lens cells [5].
  • We demonstrate that induction of NADPH-dependent quinone oxidoreductase activity by 15d-PGJ2 is markedly attenuated in mouse embryonic fibroblasts that overexpress rAor [6].
  • Chlorogenic acid also increased the enzymatic activities of glutathione S-transferases (GST) and NAD(P)H: quinone oxidoreductase [7].

Chemical compound and disease context of Cryz

  • Dicumarol (an NAD(P)H: quinone oxidoreductase inhibitor) potentiated 3-HA- or 4-methoxycatechol (4-MC) induced toxicity whereas sorbitol (an NADH generating nutrient) greatly prevented cytotoxicity indicating a quinone-mediated cytotoxic mechanism [8].

Biological context of Cryz


Anatomical context of Cryz


Associations of Cryz with chemical compounds


Other interactions of Cryz


Analytical, diagnostic and therapeutic context of Cryz


  1. An NADPH quinone reductase of Helicobacter pylori plays an important role in oxidative stress resistance and host colonization. Wang, G., Maier, R.J. Infect. Immun. (2004) [Pubmed]
  2. Metabolic activation of 4-hydroxyanisole by isolated rat hepatocytes. Moridani, M.Y., Cheon, S.S., Khan, S., O'Brien, P.J. Drug Metab. Dispos. (2002) [Pubmed]
  3. Transcriptional regulation of nicotinamide adenine dinucleotide phosphate: quinone oxidoreductase in murine hepatoma cells by 6-(methylsufinyl)hexyl isothiocyanate, an active principle of wasabi (Eutrema wasabi Maxim). Hou, D.X., Fukuda, M., Fujii, M., Fuke, Y. Cancer Lett. (2000) [Pubmed]
  4. 1,2-Bis(methylsulfonyl)-1-(2-chloroethyl)-2-[[1-(4-nitrophenyl)ethoxy]carbonyl]hydrazine: an anticancer agent targeting hypoxic cells. Seow, H.A., Penketh, P.G., Shyam, K., Rockwell, S., Sartorelli, A.C. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
  5. Lens-specific gene recruitment of zeta-crystallin through Pax6, Nrl-Maf, and brain suppressor sites. Sharon-Friling, R., Richardson, J., Sperbeck, S., Lee, D., Rauchman, M., Maas, R., Swaroop, A., Wistow, G. Mol. Cell. Biol. (1998) [Pubmed]
  6. Nrf2-mediated induction of cytoprotective enzymes by 15-deoxy-Delta12,14-prostaglandin J2 is attenuated by alkenal/one oxidoreductase. Yu, X., Egner, P.A., Wakabayashi, J., Wakabayashi, N., Yamamoto, M., Kensler, T.W. J. Biol. Chem. (2006) [Pubmed]
  7. Inhibition of activator protein-1, NF-kappaB, and MAPKs and induction of phase 2 detoxifying enzyme activity by chlorogenic acid. Feng, R., Lu, Y., Bowman, L.L., Qian, Y., Castranova, V., Ding, M. J. Biol. Chem. (2005) [Pubmed]
  8. Metabolic activation of 3-hydroxyanisole by isolated rat hepatocytes. Moridani, M.Y., Cheon, S.S., Khan, S., O'Brien, P.J. Chem. Biol. Interact. (2003) [Pubmed]
  9. Profiles of antioxidant/electrophile response element (ARE/EpRE) nuclear protein binding and c-Ha-ras transactivation in vascular smooth muscle cells treated with oxidative metabolites of benzo[a]pyrene. Miller, K.P., Chen, Y.H., Hastings, V.L., Bral, C.M., Ramos, K.S. Biochem. Pharmacol. (2000) [Pubmed]
  10. Carbonyl-metabolizing enzymes and their relatives recruited as structural proteins in the eye lens. Lee, D.C., Gonzalez, P., Rao, P.V., Zigler, J.S., Wistow, G.J. Adv. Exp. Med. Biol. (1993) [Pubmed]
  11. Tumor-specific synergistic therapy of mitomycin C: modulation of bioreductive activation. Sakamoto, N., Toge, T., Nishiyama, M. Hiroshima J. Med. Sci. (1997) [Pubmed]
  12. Presence and induction of the enzyme NAD(P)H: quinone oxidoreductase 1 in the central nervous system. Stringer, J.L., Gaikwad, A., Gonzales, B.N., Long, D.J., Marks, L.M., Jaiswal, A.K. J. Comp. Neurol. (2004) [Pubmed]
  13. A unique tertiary amine N-oxide reduction system composed of quinone reductase and heme in rat liver preparations. Kitamura, S., Sugihara, K., Tatsumi, K. Drug Metab. Dispos. (1999) [Pubmed]
  14. NAD(P)H: quinone oxidoreductase 1 expression in human bone marrow endothelial cells. Siegel, D., Ryder, J., Ross, D. Toxicol. Lett. (2001) [Pubmed]
  15. Xenobiotic induction of quinone oxidoreductase activity in lens epithelial cells. Tumminia, S.J., Rao, P.V., Zigler, J.S., Russell, P. Biochim. Biophys. Acta (1993) [Pubmed]
  16. Comparative analysis of the zeta-crystallin/quinone reductase gene in guinea pig and mouse. Gonzalez, P., Hernández-Calzadilla, C., Rao, P.V., Rodriguez, I.R., Zigler, J.S., Borrás, T. Mol. Biol. Evol. (1994) [Pubmed]
  17. Direct protective effect of NAD(P)H:quinone reductase against menadione-induced chemiluminescence of postmitochondrial fractions of mouse liver. Prochaska, H.J., Talalay, P., Sies, H. J. Biol. Chem. (1987) [Pubmed]
  18. Effects of 5-azacytidine and methyl-group deficiency on NAD(P)H: quinone oxidoreductase and glutathione S-transferase in liver. Wagner, G., Pott, U., Bruckschen, M., Sies, H. Biochem. J. (1988) [Pubmed]
  19. Identification of zeta-crystallin/NADPH:quinone reductase as a renal glutaminase mRNA pH response element-binding protein. Tang, A., Curthoys, N.P. J. Biol. Chem. (2001) [Pubmed]
  20. Up-expression of NapA and other oxidative stress proteins is a compensatory response to loss of major Helicobacter pylori stress resistance factors. Olczak, A.A., Wang, G., Maier, R.J. Free Radic. Res. (2005) [Pubmed]
  21. An Nrf2/small Maf heterodimer mediates the induction of phase II detoxifying enzyme genes through antioxidant response elements. Itoh, K., Chiba, T., Takahashi, S., Ishii, T., Igarashi, K., Katoh, Y., Oyake, T., Hayashi, N., Satoh, K., Hatayama, I., Yamamoto, M., Nabeshima, Y. Biochem. Biophys. Res. Commun. (1997) [Pubmed]
  22. Induction of drug metabolizing enzymes by 1,7-phenanthroline and oltipraz in mice is unrelated to Ah-responsiveness. Carr, B.A., Franklin, M.R. J. Biochem. Mol. Toxicol. (1999) [Pubmed]
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