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Gene Review

US10  -  virion protein US10

Human herpesvirus 2

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Disease relevance of US10

  • DNA sequence analyses of the IR5 gene region revealed an ORF of 236 amino acids (24,793 Da) that showed significant homology to ORF64 of varicella-zoster virus and ORF3 of EHV-4 both of which map within the inverted repeats and to the US10 ORF of herpes simplex virus type 1 (HSV-1) which maps within the unique short segment [1].
  • These ORFs are conserved in a similar arrangement with those of HSV-1, except for US10 which is transposed in the Us regions of all three MDV serotypes [2].
  • Consequently, no capsids were found in the cytoplasm, resulting in an inhibition of virion morphogenesis [3].
  • The myristylated virion proteins of herpes simplex virus type 1: investigation of their role in the virus life cycle [4].
  • The virion half-life of hepatitis B virus (HBV) is currently estimated at approximately 1 day [5].

High impact information on US10


Chemical compound and disease context of US10


Biological context of US10


Anatomical context of US10


Associations of US10 with chemical compounds

  • This US11 protein, which has phosphates on multiple serine residues, is brought into the cell by the virion and found to be present within ribosome fractions early after infection [21].
  • Treatment with phosphonoacetate which inhibits viral DNA synthesis and hence virion morphogenesis induced a striking increase in the time course of conversion of immature gC, gD, and gB to fully glycosylated forms when measured late in the infection [22].
  • The effects of gallic acid (3,4,5-trihydroxybenzoic acid) and its alkyl esters on virus growth and virion infectivity were examined [23].
  • A pH-sensitive activity, likely to be a virion fusion glycoprotein, is also required [24].

Analytical, diagnostic and therapeutic context of US10

  • This communication outlines a novel approach to viral inactivation by specific solvent delipidation which modifies the whole virion rendering it non-infective, but antigenic [25].


  1. Identification and characterization of an equine herpesvirus 1 late gene encoding a potential zinc finger. Holden, V.R., Yalamanchili, R.R., Harty, R.N., O'Callaghan, D.J. Virology (1992) [Pubmed]
  2. The genetic organization and transcriptional analysis of the short unique region in the genome of nononcogenic Marek's disease virus serotype 2. Jang, H.K., Ono, M., Kim, T.J., Izumiya, Y., Damiani, A.M., Matsumura, T., Niikura, M., Kai, C., Mikami, T. Virus Res. (1998) [Pubmed]
  3. The capsid-associated UL25 protein of the alphaherpesvirus pseudorabies virus is nonessential for cleavage and encapsidation of genomic DNA but is required for nuclear egress of capsids. Klupp, B.G., Granzow, H., Keil, G.M., Mettenleiter, T.C. J. Virol. (2006) [Pubmed]
  4. The myristylated virion proteins of herpes simplex virus type 1: investigation of their role in the virus life cycle. MacLean, C.A., Dolan, A., Jamieson, F.E., McGeoch, D.J. J. Gen. Virol. (1992) [Pubmed]
  5. The half-life of hepatitis B virions. Murray, J.M., Purcell, R.H., Wieland, S.F. Hepatology (2006) [Pubmed]
  6. Expression of a truncated viral trans-activator selectively impedes lytic infection by its cognate virus. Friedman, A.D., Triezenberg, S.J., McKnight, S.L. Nature (1988) [Pubmed]
  7. Herpes simplex virus VP16 rescues viral mRNA from destruction by the virion host shutoff function. Lam, Q., Smibert, C.A., Koop, K.E., Lavery, C., Capone, J.P., Weinheimer, S.P., Smiley, J.R. EMBO J. (1996) [Pubmed]
  8. Fragmentation and dispersal of Golgi proteins and redistribution of glycoproteins and glycolipids processed through the Golgi apparatus after infection with herpes simplex virus 1. Campadelli, G., Brandimarti, R., Di Lazzaro, C., Ward, P.L., Roizman, B., Torrisi, M.R. Proc. Natl. Acad. Sci. U.S.A. (1993) [Pubmed]
  9. Recombinant activation domains of virion protein 16 and human estrogen receptor generate transcriptional interference in vitro by distinct mechanisms. Pfitzner, E., Sak, A., Ulber, V., Ryffel, G.U., Klein-Hitpass, L. Mol. Endocrinol. (1993) [Pubmed]
  10. Tight control of gene expression in mammalian cells by tetracycline-responsive promoters. Gossen, M., Bujard, H. Proc. Natl. Acad. Sci. U.S.A. (1992) [Pubmed]
  11. Pseudorabies virus glycoprotein L is necessary for virus infectivity but dispensable for virion localization of glycoprotein H. Klupp, B.G., Fuchs, W., Weiland, E., Mettenleiter, T.C. J. Virol. (1997) [Pubmed]
  12. In vitro toxicological evaluation of ISIS 1082, a phosphorothioate oligonucleotide inhibitor of herpes simplex virus. Crooke, R.M., Hoke, G.D., Shoemaker, J.E. Antimicrob. Agents Chemother. (1992) [Pubmed]
  13. The herpes simplex virus 1 RNA binding protein US11 is a virion component and associates with ribosomal 60S subunits. Roller, R.J., Roizman, B. J. Virol. (1992) [Pubmed]
  14. Suppression of the interferon-mediated innate immune response by pseudorabies virus. Brukman, A., Enquist, L.W. J. Virol. (2006) [Pubmed]
  15. The octamer binding protein Oct-2 inhibits transactivation of the herpes simplex virus immediate-early genes by the virion protein Vmw65. Lillycrop, K.A., Estridge, J.K., Latchman, D.S. Virology (1993) [Pubmed]
  16. The virion host shutoff protein of herpes simplex virus inhibits reporter gene expression in the absence of other viral gene products. Pak, A.S., Everly, D.N., Knight, K., Read, G.S. Virology (1995) [Pubmed]
  17. Intracellular transport and stability of varicella-zoster virus glycoprotein K. Hall, S.L., Govero, J.L., Heineman, T.C. Virology (2007) [Pubmed]
  18. Detection of herpes simplex virus type 1 transcripts during latent infection in mice. Spivack, J.G., Fraser, N.W. J. Virol. (1987) [Pubmed]
  19. Abundant expression of herpes simplex virus glycoprotein gB using an adenovirus vector. Johnson, D.C., Ghosh-Choudhury, G., Smiley, J.R., Fallis, L., Graham, F.L. Virology (1988) [Pubmed]
  20. Immunoselection of recombinant baculoviruses expressing high levels of biologically active herpes simplex virus type 1 glycoprotein D. Ghiasi, H., Nesburn, A.B., Kaiwar, R., Wechsler, S.L. Arch. Virol. (1991) [Pubmed]
  21. The herpes simplex virus type 1 US11 gene product is a phosphorylated protein found to be non-specifically associated with both ribosomal subunits. Diaz, J.J., Simonin, D., Massé, T., Deviller, P., Kindbeiter, K., Denoroy, L., Madjar, J.J. J. Gen. Virol. (1993) [Pubmed]
  22. Individual herpes simplex virus 1 glycoproteins display characteristic rates of maturation from precursor to mature form both in infected cells and in cells that constitutively express the glycoproteins. Campadelli-Fiume, G., Lombardo, M.T., Foà-Tomasi, L., Avitabile, E., Serafini-Cessi, F. Virus Res. (1988) [Pubmed]
  23. Antiviral effect of octyl gallate against DNA and RNA viruses. Uozaki, M., Yamasaki, H., Katsuyama, Y., Higuchi, M., Higuti, T., Koyama, A.H. Antiviral Res. (2007) [Pubmed]
  24. Herpes simplex virus type 1 penetration initiates mobilization of cell surface proteins. Rosenthal, K.S., Roess, D., Barisas, B.G. Biochim. Biophys. Acta (1988) [Pubmed]
  25. Delipidation of a hepadnavirus: Viral inactivation and vaccine development. Cham, B.E., Vickery, K., Tohidi-Esfahani, R., Cossart, Y. J. Virol. Methods (2006) [Pubmed]
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