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Gene Review

CTSV  -  cathepsin V

Homo sapiens

Synonyms: CATL2, CTSL2, CTSU, Cathepsin L2, Cathepsin U, ...
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Disease relevance of CTSL2


High impact information on CTSL2


Biological context of CTSL2


Anatomical context of CTSL2


Associations of CTSL2 with chemical compounds


Regulatory relationships of CTSL2


Other interactions of CTSL2


Analytical, diagnostic and therapeutic context of CTSL2


  1. Cathepsin V is involved in the degradation of invariant chain in human thymus and is overexpressed in myasthenia gravis. Tolosa, E., Li, W., Yasuda, Y., Wienhold, W., Denzin, L.K., Lautwein, A., Driessen, C., Schnorrer, P., Weber, E., Stevanovic, S., Kurek, R., Melms, A., Bromme, D. J. Clin. Invest. (2003) [Pubmed]
  2. Cathepsin L2, a novel human cysteine proteinase produced by breast and colorectal carcinomas. Santamaría, I., Velasco, G., Cazorla, M., Fueyo, A., Campo, E., López-Otín, C. Cancer Res. (1998) [Pubmed]
  3. Cystatin M/E is a high affinity inhibitor of cathepsin V and cathepsin L by a reactive site that is distinct from the legumain-binding site. A novel clue for the role of cystatin M/E in epidermal cornification. Cheng, T., Hitomi, K., van Vlijmen-Willems, I.M., de Jongh, G.J., Yamamoto, K., Nishi, K., Watts, C., Reinheckel, T., Schalkwijk, J., Zeeuwen, P.L. J. Biol. Chem. (2006) [Pubmed]
  4. Cathepsin V, a novel and potent elastolytic activity expressed in activated macrophages. Yasuda, Y., Li, Z., Greenbaum, D., Bogyo, M., Weber, E., Brömme, D. J. Biol. Chem. (2004) [Pubmed]
  5. Increased levels of catalase and cathepsin V/L2 but decreased TIMP-1 in keratoconus corneas: evidence that oxidative stress plays a role in this disorder. Kenney, M.C., Chwa, M., Atilano, S.R., Tran, A., Carballo, M., Saghizadeh, M., Vasiliou, V., Adachi, W., Brown, D.J. Invest. Ophthalmol. Vis. Sci. (2005) [Pubmed]
  6. Genomic organization and chromosomal localization of the human cathepsin L2 gene. Itoh, R., Kawamoto, S., Adachi, W., Kinoshita, S., Okubo, K. DNA Res. (1999) [Pubmed]
  7. Fasciola hepatica cathepsin L-like proteases: biology, function, and potential in the development of first generation liver fluke vaccines. Dalton, J.P., Neill, S.O., Stack, C., Collins, P., Walshe, A., Sekiya, M., Doyle, S., Mulcahy, G., Hoyle, D., Khaznadji, E., Moiré, N., Brennan, G., Mousley, A., Kreshchenko, N., Maule, A.G., Donnelly, S.M. Int. J. Parasitol. (2003) [Pubmed]
  8. Colocalization of cystatin M/E and cathepsin V in lamellar granules and corneodesmosomes suggests a functional role in epidermal differentiation. Zeeuwen, P.L., Ishida-Yamamoto, A., van Vlijmen-Willems, I.M., Cheng, T., Bergers, M., Iizuka, H., Schalkwijk, J. J. Invest. Dermatol. (2007) [Pubmed]
  9. Isolation and characterization of human cathepsin V: a major proteinase in corneal epithelium. Adachi, W., Kawamoto, S., Ohno, I., Nishida, K., Kinoshita, S., Matsubara, K., Okubo, K. Invest. Ophthalmol. Vis. Sci. (1998) [Pubmed]
  10. The human cysteine protease cathepsin V can compensate for murine cathepsin L in mouse epidermis and hair follicles. Hagemann, S., Günther, T., Dennemärker, J., Lohmüller, T., Brömme, D., Schüle, R., Peters, C., Reinheckel, T. Eur. J. Cell Biol. (2004) [Pubmed]
  11. Crystal structure of human cathepsin V. Somoza, J.R., Zhan, H., Bowman, K.K., Yu, L., Mortara, K.D., Palmer, J.T., Clark, J.M., McGrath, M.E. Biochemistry (2000) [Pubmed]
  12. Profiling the immune response in patients with breast cancer by phage-displayed cDNA libraries. Sioud, M., Hansen, M.H. Eur. J. Immunol. (2001) [Pubmed]
  13. Comparative substrate specificity analysis of recombinant human cathepsin V and cathepsin L. Puzer, L., Cotrin, S.S., Alves, M.F., Egborge, T., Araújo, M.S., Juliano, M.A., Juliano, L., Brömme, D., Carmona, A.K. Arch. Biochem. Biophys. (2004) [Pubmed]
  14. Increased expression of elastolytic cathepsins S, K, and V and their inhibitor cystatin C in stenotic aortic valves. Helske, S., Syväranta, S., Lindstedt, K.A., Lappalainen, J., Oörni, K., Mäyränpää, M.I., Lommi, J., Turto, H., Werkkala, K., Kupari, M., Kovanen, P.T. Arterioscler. Thromb. Vasc. Biol. (2006) [Pubmed]
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