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Krt15  -  keratin 15

Mus musculus

Synonyms: AI528832, CK-15, Cytokeratin-15, K15, Keratin, type I cytoskeletal 15, ...
 
 
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Disease relevance of Krt15

  • The pathogenicity island-associated K15 capsule determinant exhibits a novel genetic structure and correlates with virulence in uropathogenic Escherichia coli strain 536 [1].
  • Klebsiella vaccines were isolated by mild diafiltration techniques from culture filtrates of nine capsular types of K. aerogenes (K1, K2, K3, K15, K20, K35, K36, K44 & K63) [2].
 

High impact information on Krt15

 

Biological context of Krt15

  • The 5' upstream regions of the mouse and human K15 genes contain homologous sequences around the respective TATA boxes, suggesting that the same factors are involved in the regulation of their transcription [7].
  • Comparison of the amino acid sequences with those of other cytokeratins revealed a high degree of conservation with respect to several other human type I cytokeratins, notably cytokeratin 15, and to the murine 47-kDa cytokeratin [8].
  • In experimental murine GVHD elicited across minor histocompatibility antigen barriers (miHA), early lesions involved selective apoptosis and loss of K15(+) staining within lingual RLPs [9].
  • Cytokeratin 15 can be used to identify the limbal phenotype in normal and diseased ocular surfaces [10].
  • Interestingly, recombination of a group 2 and 3 determinant may have been involved in the evolution of the K15 capsule-encoding gene cluster [1].
 

Anatomical context of Krt15

  • The levels of K15 and K16 were not different in the MKC-5 and MKC-6 cell lines, suggesting that they are not contributing factors to the stabilization of K5 in the mutant cells [11].
  • This novel population does not express the bulge-specific stem cell markers CD34 or keratin 15, and is infrequently BrdU label retaining [12].
  • The C8/144B monoclonal antibody recognizes cytokeratin 15 and defines the location of human hair follicle stem cells [13].
  • Using expression cloning, we identified cytokeratin 15 as the keratinocyte protein recognized by the C8/144B monoclonal antibody [13].
  • RESULTS: In human conjunctival epithelium, strong expression of K15 was observed in basal cells, whereas K19 was expressed in both basal and suprabasal layers (K15(bas)/K19(bas-sup)/K12(-)) [10].
 

Regulatory relationships of Krt15

  • In addition, the transgenic hair follicles exhibit a decreased expression of K15 as well as some hair-specific keratins and express Cldn5 and Cldn18, which are not detectable in the wild type [14].
 

Other interactions of Krt15

 

Analytical, diagnostic and therapeutic context of Krt15

  • Sequencing, Northern hybridization and genomic Southern blotting revealed that the downstream gene encodes the mouse K15 gene [7].
  • Western blot analysis was used to examine CD34 and K15 protein levels in dorsal skin isolated from SENCAR mice during multi-stage skin carcinogenesis [18].

References

  1. The pathogenicity island-associated K15 capsule determinant exhibits a novel genetic structure and correlates with virulence in uropathogenic Escherichia coli strain 536. Schneider, G., Dobrindt, U., Brüggemann, H., Nagy, G., Janke, B., Blum-Oehler, G., Buchrieser, C., Gottschalk, G., Emödy, L., Hacker, J. Infect. Immun. (2004) [Pubmed]
  2. Passive immunization of mice against Klebsiella aerogenes. Roe, E.A., Jones, R.J., Dyster, R.E. British journal of experimental pathology. (1986) [Pubmed]
  3. Multipotent nestin-positive, keratin-negative hair-follicle bulge stem cells can form neurons. Amoh, Y., Li, L., Katsuoka, K., Penman, S., Hoffman, R.M. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
  4. Implanted hair follicle stem cells form Schwann cells that support repair of severed peripheral nerves. Amoh, Y., Li, L., Campillo, R., Kawahara, K., Katsuoka, K., Penman, S., Hoffman, R.M. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
  5. Manipulation of stem cell proliferation and lineage commitment: visualisation of label-retaining cells in wholemounts of mouse epidermis. Braun, K.M., Niemann, C., Jensen, U.B., Sundberg, J.P., Silva-Vargas, V., Watt, F.M. Development (2003) [Pubmed]
  6. Regulation of basal and luminal cell-specific cytokeratin expression in rat accessory sex organs. Evidence for a new class of androgen-repressed genes and insight into their pairwise control. Hsieh, J.T., Zhau, H.E., Wang, X.H., Liew, C.C., Chung, L.W. J. Biol. Chem. (1992) [Pubmed]
  7. The complete sequence of the gene encoding mouse cytokeratin 15. Nozaki, M., Mori, M., Matsushiro, A. Gene (1994) [Pubmed]
  8. Synthesis of cytokeratin 13, a component characteristic of internal stratified epithelia, is not induced in human epidermal tumors. Kuruc, N., Leube, R.E., Moll, I., Bader, B.L., Franke, W.W. Differentiation (1989) [Pubmed]
  9. An epithelial target site in experimental graft-versus-host disease and cytokine-mediated cytotoxicity is defined by cytokeratin 15 expression. Whitaker-Menezes, D., Jones, S.C., Friedman, T.M., Korngold, R., Murphy, G.F. Biol. Blood Marrow Transplant. (2003) [Pubmed]
  10. Cytokeratin 15 can be used to identify the limbal phenotype in normal and diseased ocular surfaces. Yoshida, S., Shimmura, S., Kawakita, T., Miyashita, H., Den, S., Shimazaki, J., Tsubota, K. Invest. Ophthalmol. Vis. Sci. (2006) [Pubmed]
  11. In vitro characteristics of early epidermal progenitors isolated from keratin 14 (K14)-deficient mice: insights into the role of keratin 17 in mouse keratinocytes. Troy, T.C., Turksen, K. J. Cell. Physiol. (1999) [Pubmed]
  12. The cell-surface marker MTS24 identifies a novel population of follicular keratinocytes with characteristics of progenitor cells. Nijhof, J.G., Braun, K.M., Giangreco, A., van Pelt, C., Kawamoto, H., Boyd, R.L., Willemze, R., Mullenders, L.H., Watt, F.M., de Gruijl, F.R., van Ewijk, W. Development (2006) [Pubmed]
  13. The C8/144B monoclonal antibody recognizes cytokeratin 15 and defines the location of human hair follicle stem cells. Lyle, S., Christofidou-Solomidou, M., Liu, Y., Elder, D.E., Albelda, S., Cotsarelis, G. J. Cell. Sci. (1998) [Pubmed]
  14. Delayed epidermal permeability barrier formation and hair follicle aberrations in Inv-Cldn6 mice. Troy, T.C., Rahbar, R., Arabzadeh, A., Cheung, R.M., Turksen, K. Mech. Dev. (2005) [Pubmed]
  15. Arrangement of a cluster of three mouse type I keratin genes expressed sequentially during esophageal-type epithelial cell differentiation. Filion, M., Sarafian, V., Lussier, M., Bélanger, C., Lapointe, L., Royal, A. Genomics (1994) [Pubmed]
  16. Nestin expression in hair follicle sheath progenitor cells. Li, L., Mignone, J., Yang, M., Matic, M., Penman, S., Enikolopov, G., Hoffman, R.M. Proc. Natl. Acad. Sci. U.S.A. (2003) [Pubmed]
  17. Caveolin-1 is expressed on multipotent cells of hair follicles and might be involved in their resistance to chemotherapy. Selleri, S., Arnaboldi, F., Palazzo, M., Hussein, U., Balsari, A., Rumio, C. Br. J. Dermatol. (2005) [Pubmed]
  18. Activation of Akt and mTOR in CD34+/K15+ keratinocyte stem cells and skin tumors during multi-stage mouse skin carcinogenesis. Affara, N.I., Trempus, C.S., Schanbacher, B.L., Pei, P., Mallery, S.R., Bauer, J.A., Robertson, F.M. Anticancer Res. (2006) [Pubmed]
 
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