Gene Review:
Sphk1 - sphingosine kinase 1
Rattus norvegicus
Synonyms:
SK 1, SPK 1, Sphingosine kinase 1
- Pharmacological characterization of lysophospholipid receptor signal transduction pathways in rat cerebrocortical astrocytes. Rao, T.S., Lariosa-Willingham, K.D., Lin, F.F., Palfreyman, E.L., Yu, N., Chun, J., Webb, M. Brain Res. (2003)
- Sphingosine kinase 1 is up-regulated in colon carcinogenesis. Kawamori, T., Osta, W., Johnson, K.R., Pettus, B.J., Bielawski, J., Tanaka, T., Wargovich, M.J., Reddy, B.S., Hannun, Y.A., Obeid, L.M., Zhou, D. FASEB J. (2006)
- Involvement of sphingosine 1-phosphate in nerve growth factor-mediated neuronal survival and differentiation. Edsall, L.C., Pirianov, G.G., Spiegel, S. J. Neurosci. (1997)
- Regulatory role of sphingomyelin metabolites in hypoxia-induced vascular smooth muscle cell proliferation. Yun, J.K., Kester, M. Arch. Biochem. Biophys. (2002)
- Differential transactivation of sphingosine-1-phosphate receptors modulates NGF-induced neurite extension. Toman, R.E., Payne, S.G., Watterson, K.R., Maceyka, M., Lee, N.H., Milstien, S., Bigbee, J.W., Spiegel, S. J. Cell Biol. (2004)
- Expression of SphK1 impairs degranulation and motility of RBL-2H3 mast cells by desensitizing S1P receptors. Jolly, P.S., Bektas, M., Watterson, K.R., Sankala, H., Payne, S.G., Milstien, S., Spiegel, S. Blood (2005)
- Prosaposin treatment induces PC12 entry in the S phase of the cell cycle and prevents apoptosis: activation of ERKs and sphingosine kinase. Misasi, R., Sorice, M., Di Marzio , L., Campana, W.M., Molinari, S., Cifone, M.G., Pavan, A., Pontieri, G.M., O'Brien, J.S. FASEB J. (2001)
- Sphingosine kinase 1 is an intracellular effector of phosphatidic acid. Delon, C., Manifava, M., Wood, E., Thompson, D., Krugmann, S., Pyne, S., Ktistakis, N.T. J. Biol. Chem. (2004)
- CpG island of rat sphingosine kinase-1 gene: tissue-dependent DNA methylation status and multiple alternative first exons. Imamura, T., Ohgane, J., Ito, S., Ogawa, T., Hattori, N., Tanaka, S., Shiota, K. Genomics (2001)
- Purification and characterization of rat kidney sphingosine kinase. Olivera, A., Kohama, T., Tu, Z., Milstien, S., Spiegel, S. J. Biol. Chem. (1998)
- Distinct effects of different calcium-mobilizing agents on cell death in NG108-15 neuroblastoma X glioma cells. Chin, T.Y., Hwang, H.M., Chueh, S.H. Mol. Pharmacol. (2002)
- Extracellular release of newly synthesized sphingosine-1-phosphate by cerebellar granule cells and astrocytes. Anelli, V., Bassi, R., Tettamanti, G., Viani, P., Riboni, L. J. Neurochem. (2005)
- Novel role of sphingosine kinase 1 as a mediator of neurotrophin-3 action in oligodendrocyte progenitors. Saini, H.S., Coelho, R.P., Goparaju, S.K., Jolly, P.S., Maceyka, M., Spiegel, S., Sato-Bigbee, C. J. Neurochem. (2005)
- S1P and LPA trigger Schwann cell actin changes and migration. Barber, S.C., Mellor, H., Gampel, A., Scolding, N.J. Eur. J. Neurosci. (2004)
- Flavone acetic acid induces a G2/M cell cycle arrest in mammary carcinoma cells. Panaro, N.J., Popescu, N.C., Harris, S.R., Thorgeirsson, U.P. Br. J. Cancer (1999)
- Depolarisation induces rapid and transient formation of intracellular sphingosine-1-phosphate. Alemany, R., Kleuser, B., Ruwisch, L., Danneberg, K., Lass, H., Hashemi, R., Spiegel, S., Jakobs, K.H., Meyer zu Heringdorf, D. FEBS Lett. (2001)
- Sphingosine 1-phosphate induces expression of early growth response-1 and fibroblast growth factor-2 through mechanism involving extracellular signal-regulated kinase in astroglial cells. Sato, K., Ishikawa, K., Ui, M., Okajima, F. Brain Res. Mol. Brain Res. (1999)
- Possible involvement of cell surface receptors in sphingosine 1-phosphate-induced activation of extracellular signal-regulated kinase in C6 glioma cells. Sato, K., Tomura, H., Igarashi, Y., Ui, M., Okajima, F. Mol. Pharmacol. (1999)
- Essential requirement for sphingosine kinase activity in eNOS-dependent NO release and vasorelaxation. Roviezzo, F., Bucci, M., Delisle, C., Brancaleone, V., Di Lorenzo, A., Mayo, I.P., Fiorucci, S., Fontana, A., Gratton, J.P., Cirino, G. FASEB J. (2006)