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Gene Review

Nmbr  -  neuromedin B receptor

Mus musculus

Synonyms: BB182387, NMB-R, Neuromedin-B receptor, Neuromedin-B-preferring bombesin receptor
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Disease relevance of Nmbr


Psychiatry related information on Nmbr


High impact information on Nmbr

  • We describe the structure and expression of a cloned NMB-preferring bombesin receptor (NMB-R) with properties distinct from a GRP-preferring bombesin receptor (GRP-R) reported previously [5].
  • Compensation for NMB-R deficiency by overexpression of GRP-R and/or BRS-3 was not detected [2].
  • Administration of GRP but not NMB suppressed glucose intake in both normal and NMB-R-deficient mice [2].
  • In contrast, fundic smooth muscle contraction on stimulation with NMB or GRP was normal in NMB-R-deficient mice [2].
  • In addition, the behavioral phenotypes of GRP-R-deficient mice were not observed in NMB-R-deficient mice [2].

Biological context of Nmbr

  • These results demonstrate that activation of NMB-R can cause rapid tyrosine phosphorylation of p125(FAK) [6].
  • GRPR gene expression was detected predominantly in utero, whereas NMBR and BRS-3 genes were expressed from embryonic days 13-16 and on multiple postnatal days [7].
  • NMB inhibited cross-linking specifically and saturably with an IC50 of 4.8 and 6.1 nM for C-6 and NMB-R transfected cells, respectively, and there was a close correlation between its ability to inhibit binding and its ability to inhibit cross-linking [8].
  • The open reading frame of the putative GRP-R gene encodes for a 384-amino-acid protein which demonstrates 48% identity with the mouse BRS-3 protein and 53% identity with the mouse NMB-R protein [9].
  • Therefore, in the present study we explored the ligand-receptor interactions including kinetics, stoichiometry, internalization, degradation and regulation by guanine nucleotide binding proteins with the NMB-R and compared it to the GRP-R [10].

Anatomical context of Nmbr


Associations of Nmbr with chemical compounds


Other interactions of Nmbr

  • In the reverse study using gain-of-affinity NMBR chimeras, only replacement of EC3 of NMBR markedly increased GRP affinity [15].
  • Discovery of a novel class of neuromedin B receptor antagonists, substituted somatostatin analogues [16].
  • Serial partial deglycosylation of cross-linked NMB-Rs with PNGase F treatment for different incubation periods revealed one band of partially glycosylated receptor (53 kDa) besides the fully glycosylated and fully deglycosylated ones, showing that NMB-R has two oligosaccharide chains [8].
  • Neuraminidase digestion slightly increased the mobility of the original band in NMB-R transfected cell membranes; however, it had no effect on GRP-R transfected cell membranes [8].
  • Moreover, the plasma corticosterone level under restraint stress was elevated in NMB-R-deficient mice compared to wild-type mice [13].

Analytical, diagnostic and therapeutic context of Nmbr

  • To investigate the basis for this, we used a chimeric receptor approach to make both GRPR loss of affinity and NMBR gain of affinity chimeras and a site-directed mutagenesis approach [17].
  • CONCLUSION: 177Lu-AMBA binds with nanomolar affinity to GRP-R and NMB-R, has low retention of radioactivity in kidney, demonstrates a very favorable risk-benefit profile, and is in phase I clinical trials [18].
  • By receptor autoradiography, Lu-AMBA binds specifically to GRP-R (0.8 nmol/L) and to the neuromedin B receptor (NMB-R) (0.9 nmol/L), with no affinity for the bb3 receptor (>1,000 nmol/L) [18].
  • Furthermore, a quantitative RT-PCR analysis revealed that 5-HT(1A)-receptor gene expression is downregulated in NMB-R-deficient mice at the whole brain level [19].
  • While HPLC analysis showed that 5-HT content in the whole brain does not differ between NMB-R-deficient and wild-type mice, an immunohistochemical analysis of brain sections showed that 5-HT expression in the dorsal raphe (DR) nucleus is elevated in NMB-R-deficient mice [19].


  1. Activation of neuromedin B-preferring bombesin receptors on rat glioblastoma C-6 cells increases cellular Ca2+ and phosphoinositides. Wang, L.H., Battey, J.F., Wada, E., Lin, J.T., Mantey, S., Coy, D.H., Jensen, R.T. Biochem. J. (1992) [Pubmed]
  2. Functional properties of two bombesin-like peptide receptors revealed by the analysis of mice lacking neuromedin B receptor. Ohki-Hamazaki, H., Sakai, Y., Kamata, K., Ogura, H., Okuyama, S., Watase, K., Yamada, K., Wada, K. J. Neurosci. (1999) [Pubmed]
  3. Blockade of bombesin-like peptide receptors impairs inhibitory avoidance learning in mice. Santo-Yamada, Y., Yamada, K., Wada, E., Goto, Y., Wada, K. Neurosci. Lett. (2003) [Pubmed]
  4. Restraint stress impaired maternal behavior in female mice lacking the neuromedin B receptor (NMB-R) gene. Yamada, K., Santo-Yamada, Y., Wada, K. Neurosci. Lett. (2002) [Pubmed]
  5. cDNA cloning, characterization, and brain region-specific expression of a neuromedin-B-preferring bombesin receptor. Wada, E., Way, J., Shapira, H., Kusano, K., Lebacq-Verheyden, A.M., Coy, D., Jensen, R., Battery, J. Neuron (1991) [Pubmed]
  6. Neuromedin B receptor activation causes tyrosine phosphorylation of p125FAK by a phospholipase C independent mechanism which requires p21rho and integrity of the actin cytoskeleton. Tsuda, T., Kusui, T., Jensen, R.T. Biochemistry (1997) [Pubmed]
  7. Bombesin-like peptide receptor gene expression, regulation, and function in fetal murine lung. Shan, L., Emanuel, R.L., Dewald, D., Torday, J.S., Asokanathan, N., Wada, K., Wada, E., Sunday, M.E. Am. J. Physiol. Lung Cell Mol. Physiol. (2004) [Pubmed]
  8. Glycosylation of bombesin receptors: characterization, effect on binding, and G-protein coupling. Kusui, T., Benya, R.V., Battey, J.F., Jensen, R.T. Biochemistry (1994) [Pubmed]
  9. Molecular organization of the mouse gastrin-releasing peptide receptor gene and its promoter. Weber, H.C., Jensen, R.T., Battey, J.F. Gene (2000) [Pubmed]
  10. Ligand binding, internalization, degradation and regulation by guanine nucleotides of bombesin receptor subtypes: a comparative study. Wang, L.H., Mantey, S.A., Lin, J.T., Frucht, H., Jensen, R.T. Biochim. Biophys. Acta (1993) [Pubmed]
  11. Identification of a unique ligand which has high affinity for all four bombesin receptor subtypes. Pradhan, T.K., Katsuno, T., Taylor, J.E., Kim, S.H., Ryan, R.R., Mantey, S.A., Donohue, P.J., Weber, H.C., Sainz, E., Battey, J.F., Coy, D.H., Jensen, R.T. Eur. J. Pharmacol. (1998) [Pubmed]
  12. Tyrosine 220 in the 5th transmembrane domain of the neuromedin B receptor is critical for the high selectivity of the peptoid antagonist PD168368. Tokita, K., Hocart, S.J., Katsuno, T., Mantey, S.A., Coy, D.H., Jensen, R.T. J. Biol. Chem. (2001) [Pubmed]
  13. Modulation of 5-HT system in mice with a targeted disruption of neuromedin B receptor. Yamano, M., Ogura, H., Okuyama, S., Ohki-Hamazaki, H. J. Neurosci. Res. (2002) [Pubmed]
  14. Peptide structural requirements for antagonism differ between the two mammalian bombesin receptor subtypes. Lin, J.T., Coy, D.H., Mantey, S.A., Jensen, R.T. J. Pharmacol. Exp. Ther. (1995) [Pubmed]
  15. Molecular basis of the selectivity of gastrin-releasing peptide receptor for gastrin-releasing peptide. Tokita, K., Hocart, S.J., Coy, D.H., Jensen, R.T. Mol. Pharmacol. (2002) [Pubmed]
  16. Discovery of a novel class of neuromedin B receptor antagonists, substituted somatostatin analogues. Orbuch, M., Taylor, J.E., Coy, D.H., Mrozinski, J.E., Mantey, S.A., Battey, J.F., Moreau, J.P., Jensen, R.T. Mol. Pharmacol. (1993) [Pubmed]
  17. Molecular basis for selectivity of high affinity peptide antagonists for the gastrin-releasing peptide receptor. Tokita, K., Katsuno, T., Hocart, S.J., Coy, D.H., Llinares, M., Martinez, J., Jensen, R.T. J. Biol. Chem. (2001) [Pubmed]
  18. 177Lu-AMBA: Synthesis and characterization of a selective 177Lu-labeled GRP-R agonist for systemic radiotherapy of prostate cancer. Lantry, L.E., Cappelletti, E., Maddalena, M.E., Fox, J.S., Feng, W., Chen, J., Thomas, R., Eaton, S.M., Bogdan, N.J., Arunachalam, T., Reubi, J.C., Raju, N., Metcalfe, E.C., Lattuada, L., Linder, K.E., Swenson, R.E., Tweedle, M.F., Nunn, A.D. J. Nucl. Med. (2006) [Pubmed]
  19. Decreased marble burying behavior in female mice lacking neuromedin-B receptor (NMB-R) implies the involvement of NMB/NMB-R in 5-HT neuron function. Yamada, K., Wada, E., Yamano, M., Sun, Y.J., Ohara-Imaizumi, M., Nagamatsu, S., Wada, K. Brain Res. (2002) [Pubmed]
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