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Gene Review

Nmb  -  neuromedin B

Mus musculus

Synonyms: 3110023K12Rik, Neuromedin-B
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Disease relevance of Nmb


High impact information on Nmb


Chemical compound and disease context of Nmb

  • NMB caused rapid increases in p125(FAK) phosphorylation which reached maximum at 2 min in both rat C6 glioblastoma cells which possess native NMB-Rs and rat neuromedin B receptor (rNMR-R) transfected BALB 3T3 cells [8].
  • These results demonstrate that the rat glioblastoma cell line C-6 possesses functional NMB-preferring Bn receptors, and agonist occupation activates phospholipase C, thus increasing cytosolic Ca2+ and inositol phosphate formation [1].

Biological context of Nmb


Anatomical context of Nmb


Associations of Nmb with chemical compounds


Regulatory relationships of Nmb


Other interactions of Nmb


Analytical, diagnostic and therapeutic context of Nmb

  • Neuromedin B immunoreactivity was found in normal rat and mouse thyrotropes and weakly in "thyroidectomy" cells in hypothyroid rats, in which extractable pituitary neuromedin B was significantly depleted (thyroidectomized, 87.0 +/- 14.0; methimazole-treated, 82.0 +/- 11.4; control, 230.7 +/- 25.6 fmol/gland) [2].


  1. Activation of neuromedin B-preferring bombesin receptors on rat glioblastoma C-6 cells increases cellular Ca2+ and phosphoinositides. Wang, L.H., Battey, J.F., Wada, E., Lin, J.T., Mantey, S., Coy, D.H., Jensen, R.T. Biochem. J. (1992) [Pubmed]
  2. Localization of 7B2, neuromedin B, and neuromedin U in specific cell types of rat, mouse, and human pituitary, in rat hypothalamus, and in 30 human pituitary and extrapituitary tumors. Steel, J.H., Van Noorden, S., Ballesta, J., Gibson, S.J., Ghatei, M.A., Burrin, J., Leonhardt, U., Domin, J., Bloom, S.R., Polak, J.M. Endocrinology (1988) [Pubmed]
  3. Neuromedin-B receptor transfected BALB/3T3 cells: signal transduction and effects of ectopic receptor expression on cell growth. Dobrzanski, D., Sharoni, Y., Wada, E., Battey, J., Sausville, E. Regul. Pept. (1993) [Pubmed]
  4. Specific binding and growth effects of bombesin-related peptides on mouse colon cancer cells in vitro. Narayan, S., Guo, Y.S., Townsend, C.M., Singh, P. Cancer Res. (1990) [Pubmed]
  5. Desensitization of neuromedin B receptors (NMB-R) on native and NMB-R-transfected cells involves down-regulation and internalization. Benya, R.V., Kusui, T., Shikado, F., Battey, J.F., Jensen, R.T. J. Biol. Chem. (1994) [Pubmed]
  6. Bombesin inhibits alveolarization and promotes pulmonary fibrosis in newborn mice. Ashour, K., Shan, L., Lee, J.H., Schlicher, W., Wada, K., Wada, E., Sunday, M.E. Am. J. Respir. Crit. Care Med. (2006) [Pubmed]
  7. Discovery of a novel class of neuromedin B receptor antagonists, substituted somatostatin analogues. Orbuch, M., Taylor, J.E., Coy, D.H., Mrozinski, J.E., Mantey, S.A., Battey, J.F., Moreau, J.P., Jensen, R.T. Mol. Pharmacol. (1993) [Pubmed]
  8. Neuromedin B receptor activation causes tyrosine phosphorylation of p125FAK by a phospholipase C independent mechanism which requires p21rho and integrity of the actin cytoskeleton. Tsuda, T., Kusui, T., Jensen, R.T. Biochemistry (1997) [Pubmed]
  9. Neuromedin B receptors retain functional expression when transfected into BALB 3T3 fibroblasts: analysis of binding, kinetics, stoichiometry, modulation by guanine nucleotide-binding proteins, and signal transduction and comparison with natively expressed receptors. Benya, R.V., Wada, E., Battey, J.F., Fathi, Z., Wang, L.H., Mantey, S.A., Coy, D.H., Jensen, R.T. Mol. Pharmacol. (1992) [Pubmed]
  10. Androgen control of gene expression in the mouse meibomian gland. Schirra, F., Suzuki, T., Richards, S.M., Jensen, R.V., Liu, M., Lombardi, M.J., Rowley, P., Treister, N.S., Sullivan, D.A. Invest. Ophthalmol. Vis. Sci. (2005) [Pubmed]
  11. Bombesin-like peptide receptor gene expression, regulation, and function in fetal murine lung. Shan, L., Emanuel, R.L., Dewald, D., Torday, J.S., Asokanathan, N., Wada, K., Wada, E., Sunday, M.E. Am. J. Physiol. Lung Cell Mol. Physiol. (2004) [Pubmed]
  12. The lysosomal degradation of neuromedin B is dependent on tripeptidyl peptidase-I: evidence for the impairment of neuropeptide degradation in late-infantile neuronal ceroid lipofuscinosis. Kopan, S., Sivasubramaniam, U., Warburton, M.J. Biochem. Biophys. Res. Commun. (2004) [Pubmed]
  13. Non-peptide bombesin receptor antagonists, kuwanon G and H, isolated from mulberry. Mihara, S., Hara, M., Nakamura, M., Sakurawi, K., Tokura, K., Fujimoto, M., Fukai, T., Nomura, T. Biochem. Biophys. Res. Commun. (1995) [Pubmed]
  14. Distinguishing bombesin receptor subtypes using the oocyte assay. Shapira, H., Wada, E., Battey, J.F., Jensen, R.T., Coy, D.H., Kusano, K. Biochem. Biophys. Res. Commun. (1991) [Pubmed]
  15. Comparison of the peptide structural requirements for high affinity interaction with bombesin receptors. Lin, J.T., Coy, D.H., Mantey, S.A., Jensen, R.T. Eur. J. Pharmacol. (1995) [Pubmed]
  16. Identification of a unique ligand which has high affinity for all four bombesin receptor subtypes. Pradhan, T.K., Katsuno, T., Taylor, J.E., Kim, S.H., Ryan, R.R., Mantey, S.A., Donohue, P.J., Weber, H.C., Sainz, E., Battey, J.F., Coy, D.H., Jensen, R.T. Eur. J. Pharmacol. (1998) [Pubmed]
  17. Thyrotropin secretagogues reduce rat pituitary neuromedin B, a local thyrotropin release inhibitor. Ortiga-Carvalho, T.M., Oliveira, K.d.e. .J., Morales, M.M., Martins, V.P., Pazos-Moura, C.C. Exp. Biol. Med. (Maywood) (2003) [Pubmed]
  18. Nonpeptide neuromedin B receptor antagonists inhibit the proliferation of C6 cells. Moody, T.W., Jensen, R.T., Garcia, L., Leyton, J. Eur. J. Pharmacol. (2000) [Pubmed]
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